Dr. William Coleman Award

威廉·科尔曼博士奖

• 批准号: 9589773
• 负责人: Joyce Hunter
• 金额: $ 4.5万
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9589773
• 关键词: Affect; African American; Age; American; Area; Asian Americans; Attitude; Award; Bacteria; Behavior; Behavioral; Belief; Biochemical; Biological; Biological Factors; Biological Sciences; Birth; Boston; Buffaloes; California; Categories; Centers for Disease Control and Prevention (U.S.); Characteristics; Child; Clinical; Collaborations; Communities; Community Health; Complication; Development; Dimensions; Disease; Doctor of Philosophy; Early Diagnosis; Environment; Epidemiology; Ethnic group; Fostering; Future; Gastritis; Genes; Genetic; Genetic Risk; Genetic Variation; Health Promotion; Health Promotion Sciences; Health Services Accessibility; Health behavior; Helicobacter Infections; Helicobacter pylori; Hematological Disease; Incidence; Infection; Inherited; Institutes; Intervention; Intramural Research; Intramural Research Program; Investigation; Leg Ulcer; Life; Link; Lipopolysaccharide Biosynthesis Pathway; Malignant neoplasm of prostate; Master of Public Health; Mental Health; Mental disorders; Mentorship; Mexican Americans; Mission; Molecular Biology; National Cancer Institute; National Human Genome Research Institute; Natural Sciences; Not Hispanic or Latino; Outcome; Pacific Island Americans; Patients; Population; Postdoctoral Fellow; Prevention strategy; Process; Public Health Schools; Race; Recording of previous events; Research; Research Personnel; Risk; Risk Factors; Role; Science; Scientist; Services; Sickle Cell; Sickle Cell Anemia; Sickle Cell Trait; Stomach; Symptoms; Time; Training; Training Programs; Ulcer; United States National Institutes of Health; Universities; Work; adaptive immune response; biobehavior; burden of illness; cancer epidemiology; cancer genetics; cancer risk; career; disorder prevention; exome; exome sequencing; experience; genetic epidemiology; global health; health care availability; health disparity; high risk; high risk population; improved; innovation; insight; malignant stomach neoplasm; member; men; metabolomics; microbiome; minority health; population based; programs; prospective; psychosocial; social; social stigma; trait; young adult

NIMHD announced the 2017 William G. Coleman, Jr., Ph.D., Minority Health and Health Disparities Research Innovation Award. Dr. Coleman was a distinguished member of the scientific community. He became the first permanent African American scientific director in the history of the NIH Intramural Research Program in January 2011 when he was appointed to direct the NIMHD Intramural Research Program. He was responsible for directing NIMHDs trans-disciplinary portfolio focusing primarily on the biological and non-biological determinants of health disparities. His research included substantial work on the biosynthesis of lipopolysaccharide and on the innate and adaptive immune response to Helicobacter pylori infection. H. pylori, a type of bacteria that causes infection in the stomach, is associated with gastritis, ulcers and gastric cancers, which affect millions of Americans and is more common among Mexican Americans and non-Hispanic blacks. Dr. Coleman was known as a proponent of mentorship, and dedicated much of his time to training future scientists - particularly around disparities research. The Coleman Award, a competitive award, seeks to support innovative research ideas and concepts - proposing potential for high impact in areas of minority health and health disparities research. The application process was opened to postdoctoral fellows, staff scientists, and staff clinicians under the mentorship of either NIMHD intramural or NIMHD adjunct intramural investigators. Applicants were required to present a three-page proposal, central hypothesis, detailed specific aims, and a discussion of the expected outcome and possible anticipated pitfalls to the approach. They were also asked to include a description of how successful completion of the proposal will influence the advancement of the science of minority health and, or health disparities. The award provides opportunities for investigators who are early in their careers to conduct studies that we hope will help advance the science of minority health and health disparities. Award recipients received $15,000, each for supplies and services to be used in FY 2017. Three postdoctoral fellows within the NIH Intramural Research Program were selected to receive the first William G. Coleman Jr., Ph.D., Minority Health and Health Disparities Research Innovation Award. The awardees are fellows at NCI, NHGRI, and NIMHD. They are: Dr. Tracy M. Layne is a postdoctoral fellow at the National Cancer Institute. She received her M.P.H. at the Boston University School of Public Health with a concentration in epidemiology. Dr. Layne then completed her Ph.D. as part of the Yale-National Cancer Institute Partnership Training Program in Cancer Epidemiology in the Division of Cancer Epidemiology and Genetics. Her project Prospective Metabolomic Profiling and Prostate Cancer Risk in African American Men, seeks to identify the biochemical characteristics of prostate cancer in African American men that may contribute to their excess disease burden. According to the Centers for Disease Control and Prevention (link is external), African American men have the highest incidence rate, and are more likely to die from prostate cancer than any other racial or ethnic group. Research also shows that African American men experience more aggressive forms of disease and at younger ages. Despite these long-standing disparities, this population remains an under-studied, high risk group. Further research is needed to bridge the gaps in our understanding of this disease among African American men. Dr. Candace Middlebrooks is a postdoctoral fellow at the National Human Genome Research Institute. She obtained a M.S. degree in Natural Science from the University of Buffalo and a Ph.D. in Genetics and Molecular Biology at Emory University where she performed research in the field of Genetic Epidemiology. Her project Investigation of Genetic Risk Modifiers of Leg Ulcer Development in Sickle Cell Patients Using Whole Exome Sequencing and Microbiome Characterization, will examine the germline whole exome sequences of the INSIGHTS study patients who have, or do not have leg ulcers - to identify genetic variation that may contribute to increased risk for leg ulcers. Leg ulcers are a common and disabling complication of sickle cell disease (SCD), which is an inherited blood disorder that is present at birth and affects approximately 100,000 Americans. One in 13 African American babies (link is external) is born with the sickle cell trait (SCT), meaning they carry a single gene for SCD and can pass it along to their children; however, trait carriers usually do not have symptoms of SCD and live a normal life. Dr. Melanie Sabado is a postdoctoral fellow at NIMHD. She earned her Ph.D. in Health Promotion Sciences with a focus in Community and Global Health from Claremont Graduate University. She received her M.P.H. with a concentration in Health Promotion and Disease Prevention from California State University, Fullerton. Her project Assessment of Mental Health Behaviors and Stigma Among Young Adult Pacific Islanders, will explore young adult Pacific Islander needs, attitudes, and beliefs regarding mental health and factors that encourage or hinder their participation in health care services, access, and utilization. Over 2.2 million of the Asian American-Pacific Islander population had a diagnosable mental illness in 2014. Mental health disparities are understudied and underrepresented among Pacific Islander communities, where a better understanding about cultural stigma, as well as other barriers to seeking treatment and access to care can begin to provide insights toward better outcomes.

NIMHD 宣布颁发 2017 年 William G. Coleman, Jr., Ph.D. 少数族裔健康和健康差异研究创新奖。 科尔曼博士是科学界的杰出成员。 2011 年 1 月，他被任命指导 NIMHD 校内研究项目，成为 NIH 校内研究项目历史上第一位常任非裔美国科学主任。 他负责指导 NIMHD 的跨学科投资组合，主要关注健康差异的生物和非生物决定因素。 他的研究包括脂多糖生物合成以及对幽门螺杆菌感染的先天性和适应性免疫反应的大量工作。幽门螺杆菌是一种引起胃部感染的细菌，与胃炎、溃疡和胃癌有关，影响着数百万美国人，在墨西哥裔美国人和非西班牙裔黑人中更为常见。 科尔曼博士以导师制的支持者而闻名，他将大部分时间投入到培训未来的科学家——特别是围绕差异研究。科尔曼奖是一项竞争性奖项，旨在支持创新的研究思想和概念——提出在少数族裔健康和健康差异研究领域产生巨大影响的潜力。申请流程在 NIMHD 校内或 NIMHD 兼职校内研究人员的指导下向博士后研究员、科学家和临床医生开放。 申请人需要提出一份三页纸的提案、中心假设、详细的具体目标，以及对该方法的预期结果和可能的预期陷阱的讨论。 他们还被要求描述该提案的成功完成将如何影响少数族裔健康和/或健康差异科学的进步。该奖项为处于职业生涯早期的研究人员提供了进行研究的机会，我们希望这些研究将有助于推进少数族裔健康和健康差异的科学发展。获奖者每人获得 15,000 美元，用于 2017 财年使用的物资和服务。 NIH 校内研究项目的三名博士后研究员被选为获得首届 William G. Coleman Jr. 博士少数族裔健康与健康差异研究创新奖。 获奖者是 NCI、NHGRI 和 NIMHD 的研究员。 他们是： Tracy M. Layne 博士是美国国家癌症研究所的博士后研究员。她获得了公共卫生硕士学位。在波士顿大学公共卫生学院，主修流行病学。莱恩博士随后完成了她的博士学位。作为癌症流行病学和遗传学部门的耶鲁大学-国家癌症研究所癌症流行病学合作培训计划的一部分。 她的项目《非裔美国男性的前瞻性代谢组学分析和前列腺癌风险》旨在确定非裔美国男性前列腺癌的生化特征，这些特征可能导致其疾病负担过重。根据疾病控制和预防中心 (link is external) 的数据，非裔美国男性的发病率最高，并且比任何其他种族或族裔群体更有可能死于前列腺癌。 研究还表明，非裔美国男性在年轻时会罹患更具侵袭性的疾病。 尽管存在这些长期差异，但这一人群仍然是一个研究不足的高风险群体。 需要进一步的研究来弥合我们对非裔美国男性这种疾病的理解差距。 Candace Middlebrooks 博士是国家人类基因组研究所的博士后研究员。她获得了硕士学位。布法罗大学自然科学学士学位和博士学位。她在埃默里大学获得遗传学和分子生物学博士学位，在那里进行遗传流行病学领域的研究。她的项目“使用全外显子组测序和微生物组表征对镰状细胞患者腿部溃疡发展的遗传风险修饰因素进行调查”将检查患有或不患有腿部溃疡的 INSIGHTS 研究患者的种系全外显子序列，以确定可能导致腿部溃疡风险增加的遗传变异。 腿部溃疡是镰状细胞病 (SCD) 的一种常见致残性并发症，镰状细胞病是一种出生时就存在的遗传性血液疾病，影响大约 100,000 名美国人。十分之一的非裔美国婴儿 (link is external) 出生时就患有镰状细胞性状 (SCT)，这意味着他们携带 SCD 的单个基因，并且可以将其遗传给他们的孩子；然而，特征携带者通常没有 SCD 症状并过着正常的生活。 Melanie Sabado 博士是 NIMHD 的博士后研究员。她获得了博士学位。克莱蒙特研究生大学健康促进科学专业，重点研究社区和全球健康。她获得了公共卫生硕士学位。毕业于加州州立大学富勒顿分校，主修健康促进和疾病预防。她的项目“太平洋岛民青年心理健康行为和耻辱评估”将探讨太平洋岛民青年对心理健康的需求、态度和信念，以及鼓励或阻碍他们参与、获取和利用医疗保健服务的因素。 2014 年，超过 220 万亚裔美国人和太平洋岛民患有可诊断的精神疾病。太平洋岛民社区中的心理健康差异研究不足，代表性不足，更好地了解文化耻辱以及寻求治疗和获得护理的其他障碍可以开始为获得更好的结果提供见解。