Duke-UNC Chapel Hill Immunotherapy Training Grant

杜克大学-北卡罗来纳大学教堂山免疫治疗培训补助金

• 批准号: 9359326
• 负责人: Nelson J. Chao
• 金额: $ 47.03万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9359326
• 关键词: Grant; Immunotherapy; Training

Abstract: This is a combined training grant from the University of North Carolina at Chapel Hill (UNC-CH) and Duke University (Duke UNC Immunotherapy Training Grant; DUNC-IMTG). The DUNC-IMTG will train postdoctoral fellows in translational and clinical research focusing on tumor immunotherapy and/or stem cell transplantation immunology. This is an area of rapid growth and interest with exciting new therapies being evaluated in the treatment of patients with multiple different forms of cancer. Despite this intense enthusiasm, these areas are vastly underrepresented in current training programs leading to a paucity of trained investigators to work in these rapidly expanding areas. The DUNC-IMTG supports the training of six trainees yearly at UNC-CH and Duke University. We have identified 21 senior mentors and 3 junior mentors with outstanding qualifications at UNC-CH and Duke University to instruct individuals supported by this training program. These investigators' interests include vaccine design and vector generation, adoptive cellular therapy, novel approaches to understand the function of checkpoint inhibitors, the role of immune cells in the tumor microenvironment and enhancing our understanding of the biology of immune cells in stem cell transplantation. We have an extremely novel mechanism for training with an emphasis on didactic coursework in statistical design, bioinformatics and proteomics, and seminar courses. Importantly, all trainees take these courses together, which allows access to trainees of each institution to world-class instructors from both institutions. All trainees will participate in Immunotherapy Working Groups, which are translational teams that assist in the development of novel immunotherapies, allowing all trainees to be involved in the development of biomarkers and clinical trials for the treatment of patients with cancer. Additionally, we have a robust and comprehensive approach to training underrepresented minorities. Strengths of the program include an extremely strong group of mentors with substantial experience training postdoctoral fellows, an outstanding leadership group with a long history of training translational and clinical investigators, the presence of world-class vaccine and transplant infrastructure allowing for the development and implementation of translational cutting-edge clinical trials and a strong track record of collaborative training grants with outstanding training success between Duke University and the University of North Carolina at Chapel Hill. Finally, we have identified an outstanding group of potential trainees who could participate as trainees in this program. This program combines the mentors, infrastructure and resources of two world-class institutions to provide novel training in a critically important area of clinical and translational research.

抽象的： 这是北卡罗来纳大学教堂山（UNC-CH）和杜克大学的综合培训补助金 大学（Duke UNC免疫疗法培训补助金； DUNC-IMTG）。 DUNC-IMTG将训练博士后 转化和临床研究的研究员，重点是肿瘤免疫疗法和/或干细胞移植 免疫学。这是一个快速增长和兴趣的领域，并在评估中评估了令人兴奋的新疗法 治疗多种不同形式的癌症的患者。尽管热情充满热情，但这些领域是 在当前的培训计划中的人数大大不足，导致训练有素的调查人员工作很少 这些迅速扩展的地区。 DUNC-IMTG每年在UNC-CH和杜克大学对六名学员进行培训。我们有 确定了21位高级导师和3位初级导师，并在UNC-CH和杜克大学获得出色的资格 大学指示该培训计划支持的个人。这些调查人员的兴趣包括 疫苗设计和载体的产生，产物蜂窝疗法，了解该功能的新方法 在检查点抑制剂中，免疫细胞在肿瘤微环境中的作用并增强了我们 理解干细胞移植中免疫细胞的生物学。我们有一个非常新颖的 培训的机制，重点是统计设计，生物信息学和 蛋白质组学和研讨会课程。重要的是，所有学员一起参加这些课程，可以访问 每个机构的受训者都来自两个机构的世界一流的教练。所有学员将参加 免疫疗法工作组，是转化团队，有助于发展新颖 免疫疗法，使所有学员都可以参与生物标志物的开发和临床试验的发展 癌症患者的治疗。此外，我们采取了强大而全面的培训方法 代表性不足的少数民族。 该计划的优势包括一群非常强大的导师，并具有丰富的经验培训 博士后研究员，一个杰出的领导小组 研究人员，世界一流的疫苗和移植基础设施的存在允许开发 并实施转化尖端临床试验和协作培训的良好记录 杜克大学和北卡罗来纳大学的培训成功获得了杰出培训的赠款 教堂山。最后，我们确定了一群杰出的潜在学员，他们可以参与 该计划的受训者。该计划结合了两个世界级的导师，基础设施和资源 在临床和转化研究非常重要的领域提供新颖培训的机构。