Duke-UNC Chapel Hill Immunotherapy Training Grant

摘要： 这是北卡罗来纳大学教堂山分校(UNC-CH)和杜克大学联合提供的培训补助金 大学(杜克大学北卡罗来纳大学免疫治疗培训补助金；Dunc-IMTG)。DUNC-IMTG将培养博士后 专注于肿瘤免疫治疗和/或干细胞移植的翻译和临床研究研究员 免疫学。这是一个快速增长和感兴趣的领域，令人兴奋的新疗法正在评估中 治疗多种不同形式癌症的患者。尽管有这种强烈的热情，但这些领域是 在目前的培训方案中任职人数极少，导致受过培训的调查人员很少 这些快速扩张的地区。 Dunc-IMTG支持每年在北卡罗来纳大学和杜克大学培训六名实习生。我们有 在北卡罗来纳大学和杜克大学确定了21名具有杰出资质的高级导师和3名初级导师 大学指导受此培训计划支持的个人。这些调查人员的兴趣包括 疫苗设计和载体生成，采用细胞疗法，了解功能的新方法 检查点抑制剂，免疫细胞在肿瘤微环境中的作用，并增强我们的 了解干细胞移植中的免疫细胞生物学。我们有一本非常新奇的 培训机制，重点是统计设计、生物信息学和 蛋白质组学和研讨会课程。重要的是，所有学员都一起参加这些课程，这样就可以访问 从两所院校的实习生到两所院校的世界级教师。所有受训人员将参加 免疫治疗工作组，这是帮助开发新的 免疫疗法，允许所有受训人员参与生物标记物的开发和临床试验 癌症患者的治疗。此外，我们拥有强大而全面的培训方法 代表不足的少数族裔。 该计划的优势包括一批非常强大的导师，他们都接受过丰富的经验培训 博士后，具有悠久的翻译和临床培训历史的杰出领导团队 研究人员、世界级疫苗的存在和移植基础设施的存在使这一开发得以实现 以及实施转化型尖端临床试验和协作培训的良好记录 杜克大学和北卡罗来纳大学之间在培训方面取得显著成功的赠款 教堂山。最后，我们确定了一批优秀的潜在实习生，他们可以作为 这个项目的实习生。该项目结合了两个世界级的教师、基础设施和资源 在临床和转化性研究这一至关重要的领域提供新的培训机构。

Abstract: This is a combined training grant from the University of North Carolina at Chapel Hill (UNC-CH) and Duke University (Duke UNC Immunotherapy Training Grant; DUNC-IMTG). The DUNC-IMTG will train postdoctoral fellows in translational and clinical research focusing on tumor immunotherapy and/or stem cell transplantation immunology. This is an area of rapid growth and interest with exciting new therapies being evaluated in the treatment of patients with multiple different forms of cancer. Despite this intense enthusiasm, these areas are vastly underrepresented in current training programs leading to a paucity of trained investigators to work in these rapidly expanding areas. The DUNC-IMTG supports the training of six trainees yearly at UNC-CH and Duke University. We have identified 21 senior mentors and 3 junior mentors with outstanding qualifications at UNC-CH and Duke University to instruct individuals supported by this training program. These investigators' interests include vaccine design and vector generation, adoptive cellular therapy, novel approaches to understand the function of checkpoint inhibitors, the role of immune cells in the tumor microenvironment and enhancing our understanding of the biology of immune cells in stem cell transplantation. We have an extremely novel mechanism for training with an emphasis on didactic coursework in statistical design, bioinformatics and proteomics, and seminar courses. Importantly, all trainees take these courses together, which allows access to trainees of each institution to world-class instructors from both institutions. All trainees will participate in Immunotherapy Working Groups, which are translational teams that assist in the development of novel immunotherapies, allowing all trainees to be involved in the development of biomarkers and clinical trials for the treatment of patients with cancer. Additionally, we have a robust and comprehensive approach to training underrepresented minorities. Strengths of the program include an extremely strong group of mentors with substantial experience training postdoctoral fellows, an outstanding leadership group with a long history of training translational and clinical investigators, the presence of world-class vaccine and transplant infrastructure allowing for the development and implementation of translational cutting-edge clinical trials and a strong track record of collaborative training grants with outstanding training success between Duke University and the University of North Carolina at Chapel Hill. Finally, we have identified an outstanding group of potential trainees who could participate as trainees in this program. This program combines the mentors, infrastructure and resources of two world-class institutions to provide novel training in a critically important area of clinical and translational research.