Duke-UNC Chapel Hill Immunotherapy Training Grant

杜克大学-北卡罗来纳大学教堂山免疫治疗培训补助金

• 批准号: 9359326
• 负责人: Nelson J. Chao
• 金额: $ 47.03万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9359326
• 关键词: Grant; Immunotherapy; Training

Abstract: This is a combined training grant from the University of North Carolina at Chapel Hill (UNC-CH) and Duke University (Duke UNC Immunotherapy Training Grant; DUNC-IMTG). The DUNC-IMTG will train postdoctoral fellows in translational and clinical research focusing on tumor immunotherapy and/or stem cell transplantation immunology. This is an area of rapid growth and interest with exciting new therapies being evaluated in the treatment of patients with multiple different forms of cancer. Despite this intense enthusiasm, these areas are vastly underrepresented in current training programs leading to a paucity of trained investigators to work in these rapidly expanding areas. The DUNC-IMTG supports the training of six trainees yearly at UNC-CH and Duke University. We have identified 21 senior mentors and 3 junior mentors with outstanding qualifications at UNC-CH and Duke University to instruct individuals supported by this training program. These investigators' interests include vaccine design and vector generation, adoptive cellular therapy, novel approaches to understand the function of checkpoint inhibitors, the role of immune cells in the tumor microenvironment and enhancing our understanding of the biology of immune cells in stem cell transplantation. We have an extremely novel mechanism for training with an emphasis on didactic coursework in statistical design, bioinformatics and proteomics, and seminar courses. Importantly, all trainees take these courses together, which allows access to trainees of each institution to world-class instructors from both institutions. All trainees will participate in Immunotherapy Working Groups, which are translational teams that assist in the development of novel immunotherapies, allowing all trainees to be involved in the development of biomarkers and clinical trials for the treatment of patients with cancer. Additionally, we have a robust and comprehensive approach to training underrepresented minorities. Strengths of the program include an extremely strong group of mentors with substantial experience training postdoctoral fellows, an outstanding leadership group with a long history of training translational and clinical investigators, the presence of world-class vaccine and transplant infrastructure allowing for the development and implementation of translational cutting-edge clinical trials and a strong track record of collaborative training grants with outstanding training success between Duke University and the University of North Carolina at Chapel Hill. Finally, we have identified an outstanding group of potential trainees who could participate as trainees in this program. This program combines the mentors, infrastructure and resources of two world-class institutions to provide novel training in a critically important area of clinical and translational research.

抽象的： 这是北卡罗来纳大学教堂山分校 (UNC-CH) 和杜克大学联合提供的培训资助 大学（北卡罗来纳大学杜克大学免疫治疗培训补助金；DUNC-IMTG）。 DUNC-IMTG将培养博士后 专注于肿瘤免疫治疗和/或干细胞移植的转化和临床研究研究员 免疫学。这是一个快速增长和令人感兴趣的领域，正在评估令人兴奋的新疗法 治疗患有多种不同形式的癌症的患者。尽管有如此强烈的热情，这些领域 目前的培训计划中的代表性严重不足，导致缺乏训练有素的调查员来工作 这些快速扩张的领域。 DUNC-IMTG 每年支持 UNC-CH 和杜克大学培训六名学员。我们有 在 UNC-CH 和杜克大学确定了 21 名高级导师和 3 名初级导师，他们具有出色的资历 大学指导受此培训计划支持的个人。这些调查人员的兴趣包括 疫苗设计和载体生成、过继细胞疗法、了解功能的新方法 检查点抑制剂、免疫细胞在肿瘤微环境中的作用以及增强我们的免疫能力 了解干细胞移植中免疫细胞的生物学。我们有一个非常新颖的 培训机制，重点是统计设计、生物信息学和 蛋白质组学和研讨会课程。重要的是，所有学员一起参加这些课程，这样就可以访问 每个机构的学员以及来自两个机构的世界级讲师。所有学员都将参加 免疫治疗工作组是协助开发新疗法的翻译团队 免疫疗法，允许所有学员参与生物标志物的开发和临床试验 癌症患者的治疗。此外，我们还有强大而全面的培训方法 代表性不足的少数群体。 该计划的优势包括拥有丰富培训经验的极其强大的导师团队 博士后研究员，一个具有悠久的转化和临床培训历史的杰出领导团队 研究人员认为，世界一流的疫苗和移植基础设施的存在有利于开发 和实施转化性尖端临床试验以及良好的协作培训记录 杜克大学和北卡罗来纳大学之间的杰出培训资助 教堂山。最后，我们确定了一批优秀的潜在学员，他们可以作为 该计划的受训者。该项目结合了两个世界级的导师、基础设施和资源 机构在临床和转化研究的至关重要领域提供新颖的培训。