Integrated treatments for core deficits in autism spectrum disorder

自闭症谱系障碍核心缺陷的综合治疗

基本信息

批准号：
9212010
负责人：
LATHA Valluripalli SOORYA
金额：
$ 14.68万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2020-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9212010
关键词：
11 year old Academic Medical Centers Address Adolescent Adverse effects Affect Affective Aftercare Age Attention Award Base of the Brain Behavior Behavior Therapy Behavioral Biological California Chicago Child Childhood Clinical Cognition Cognitive Cognitive Therapy Collaborations Combined Modality Therapy Complex Consultations Cycloserine Data Development Disease Dose Educational Curriculum Educational Intervention Emotional Emotions Eye Future Glutamates Goals Heterogeneity Human Illinois Impaired cognition Impairment Individual Interpersonal Relations Intervention Intervention Studies Investigation Learning Longevity Los Angeles Maintenance Measurement Measures Mediating Mediation Memory Mental disorders Mentored Patient-Oriented Research Career Development Award Mentorship Mind Modality Molecular Neuropeptides Neurosciences Neurosecretory Systems Noise Nonverbal Communication North Carolina Outcome Oxytocin Pathogenicity Pathway interactions Perception Peripheral Pharmacological Treatment Pharmacotherapy Phenotype Pilot Projects Play Prevalence Process Psyche structure Quality of life Randomized Regulation Research Research Training Role Safety School-Age Population Signal Transduction Social Behavior Social Controls Social support Socialization Supervision Symptoms System Therapeutic Training Programs Treatment Efficacy Treatment Factor Treatment Protocols United States Universities Youth autism spectrum disorder base behavioral pharmacology brain behavior communication behavior comparative trial cooking critical developmental period design disability drug discovery effective intervention gamma-Aminobutyric Acid group intervention impression improved information processing interest life time cost medical schools mental state neuromechanism neuropsychiatric disorder next generation novel predicting response predictive of treatment response psychosocial public health relevance rehearsal skills skills training social social cognition social communication social group social learning social skills targeted treatment theories therapy design treatment effect

项目摘要

DESCRIPTION (provided by applicant): Despite progress in efficacious treatments for individuals with autism spectrum disorder (ASD), few interventions are available for disease-specific impairments. The complexity and heterogeneity of ASD suggests interventions targeting multiple domains are more likely to have a therapeutic impact. This Mentored Patient-Oriented Research Career Development Award supports the candidate's long-term goals of building effective interventions for core symptoms in ASD with capacity to integrate the rapidly evolving findings from both behavioral intervention and drug discovery research. The training program and supervised activities will focus on gaining expertise in the molecular and neural mechanisms underlying phenotypic diversity in ASD, interrogating active ingredients from combination therapies, and investigating mechanisms underlying both behavioral and pharmacological treatments. The award is will be based at the Rush University Medical Center under the mentorship of Dr. Mark Pollack and co-mentorship of Drs. Ed Cook, Luan Phan, and Don Hedeker at the University of Illinois-Chicago; and with consultation from national experts including Drs. Connie Kasari (University of California, Los Angeles), Linmarie Sikich (University of North Carolina-Chapel Hill), and Kevin Pelphrey (Yale School of Medicine). The candidate's immediate focus is to study a novel, behavioral- pharmacological therapy targeting higher-order social information processing impairments in youth with ASD. The research plan proposes a proof-of-concept, combination intervention designed to address individual treatment targets presumed to influence social learning in school aged children with ASD. This proposal builds upon data from the applicant's randomized, comparative trial of a targeted cognitive-behavioral intervention (CBI) for nonverbal communication, emotion recognition, and theory of mind deficits in youth with ASD. We will evaluate the safety, tolerability, and efficacy of combining the neuropeptide oxytocin (OT) with the targeted CBI group curriculum. The research plan will randomize 8-11 year old youth with ASDs (n=50), into a 12- session, randomized, parallel group design of CBI+OT or a control social group condition (facilitated play). It is hypothesized that targeted, intranasal OT dosing immediately prior to CBI group activities will serve enhance social cognition during group and homework activities, facilitate behavioral rehearsal of target skills, and yield changes in both behavioral and cognitive domains supporting social learning during childhood. In collaboration with the mentorship team, the research plan will investigate a candidate task battery drawing from neuroscience measurement strategies of brain-behavior relationships underlying social cognition and affective regulation. The candidate task battery will be used refine treatment targets and identify potential social cognitive mechanisms predicting treatment response from the combined social cognitive intervention.

描述（由适用提供）：尽管对自闭症谱系障碍（ASD）患者有效治疗的进展，但很少有干预措施可用于特定疾病的障碍。 ASD的复杂性和异质性表明，针对多个领域的干预措施更有可能产生治疗影响。这项指导的以患者为导向的研究职业发展奖支持候选人的长期目标，即建立ASD中的核心症状的有效干预措施，并能够整合行为干预和药物发现研究中快速发展的发现。培训计划和监督活动将着重于获得ASD中表型多样性的分子和神经元机制的专业知识，从组合疗法中询问主动剂量，并研究行为和药物治疗的基本机制。该奖项将以马克·波拉克（Mark Pollack）博士的心态和博士的授权为基础。伊利诺伊大学 - 芝加哥大学的Ed Cook，Luan Phan和Don Hedeker；并在包括博士在内的国家专家的咨询中。康妮·卡萨里（Connie Kasari）（加利福尼亚大学，洛杉矶分校），林马里·西基奇（Linmarie Sikich）（北卡罗来纳大学 - 教堂山）和凯文·佩尔弗里（Kevin Pelphrey）（耶鲁大学医学院）。候选人的直接重点是研究一种针对ASD青少年的高阶社会信息处理障碍的新型行为 - 药理治疗。该研究计划提出了一种概念验证，旨在解决旨在影响ASD学龄儿童社会学习的个人治疗目标的组合干预措施。该提案基于申请人对非语言交流，情感识别和心理理论的目标认知行为干预（CBI）的随机比较试验的数据，在ASD的青年中定义了。我们将评估将神经肽催产素（OT）与靶向CBI组课程相结合的安全性，耐受性和效率。该研究计划将将8-11岁的ASD年轻人（n = 50）随机，将CBI+OT的随机，平行组设计或控制社会群体条件（促进游戏）随机，随机，平行的群体设计。假设有针对性的，鼻内的OT剂量在CBI小组活动之前将有助于提高小组和家庭作业活动期间的社会认知，促进目标技能的行为彩排，并在支持童年期间支持社会学习的行为和认知领域的变化。与Mentalship团队合作，该研究计划将调查来自脑行为关系的神经科学测量策略的候选任务电池，这是社会认知和情感监管的基础。候选任务电池将可以使用完善的治疗靶标，并确定潜在的社会认知机制，从而预测联合社会认知干预措施的治疗反应。