The J. Craig Venter Institute Genome Center for Infectious Diseases

J. Craig Venter 研究所传染病基因组中心

• 批准号: 9241319
• 负责人: Karen E. Nelson
• 金额: $ 572.8万
• 依托单位: J. CRAIG VENTER INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-04 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9241319
• 关键词: Address; Animals; Antibiotic Resistance; Antifungal Agents; Bacteria; Basic Science; Biology; Communicable Diseases; Communities; Complex; Computer Analysis; Country; Data; Data Analyses; Data Set; Drug Targeting; Drug resistance; Genome; Genomic approach; Genomics; Human; Immune Evasion; Immunity; Institutes; Institution; Instruction; Plasmodium falciparum; Prevention; Public Health; Research Infrastructure; Research Project Grants; Resources; Sampling; Software Tools; Technology; Virulence; Virus; aging population; base; data management; innovation; insight; malaria infection; microbiome; novel; outreach program; pathogen; programs; tool; transcriptomics

For the past 21 years, the J. Craig Venter Institute (JCVI) has applied leading edge genomics approaches to diverse problems in biology. Through significant changes in sequencing technology, an emphasis has been maintained on establishing a robust sample and data handling infrastructure and computational analysis tools to take advantage of increasingly large and complex genomic and transcriptomic datasets. The JCVI Genomic Center for Infectious Diseases (GCID) is built around a central theme - the application of innovative genomics-based approaches to study pathogens and determinants of their virulence, drug-resistance, immune-evasion, and interactions with the host and the host microbiome. The JCVI GCID will address critical issues in pathogen biology including (among others), the evolutionary dynamics of viruses in human hosts and animal reservoirs, the dissemination of antibiotic resistance in bacteria, the search for novel antifungal drug targets, and the basis for immunity to malaria infection by Plasmodium falciparum. The hypothesis-driven Research Projects will be supported by a Technology Core and a Data Management and Analysis and Resource Dissemination (DMARD) Core. An Administrative Core will assure effective management and integration of the Program components so as to take best advantage of shared approaches, samples, and insights. An outreach program will be established to promote the use of genomics in other institutions and countries. All of the data, software tools, and strain resources will rapidly be made publicly available to support the broadest use by the scientific community. The impact of the JCVI Program will prove to be very high as it addresses the basic science issues that will underpin solutions to some of the major problems and challenges in the prevention and management of infectious diseases today.

在过去的21年里，J.克雷格文特尔研究所（JCVI）应用了领先的基因组学方法， 生物学中的各种问题。通过测序技术的重大变化， 继续建立健全的样本和数据处理基础设施以及计算分析 利用日益庞大和复杂的基因组和转录组数据集的工具。JCVI 传染病基因组中心（GCID）围绕一个中心主题建立--应用 以基因组学为基础的创新方法来研究病原体及其毒力、耐药性 免疫逃避以及与宿主和宿主微生物组的相互作用。JCVI GCID将 解决病原体生物学中的关键问题，包括（除其他外）， 人类宿主和动物宿主，细菌中抗生素耐药性的传播， 新的抗真菌药物靶标，以及对恶性疟原虫感染的疟疾免疫的基础。的 假设驱动的研究项目将得到技术核心和数据管理的支持， 分析和资源传播（DMARD）核心。行政核心将确保有效的 管理和整合计划组成部分，以便充分利用共享的 方法、样本和见解。将建立一个推广方案， 基因组学在其他机构和国家。所有的数据、软件工具和应变资源将迅速 公开提供，以支持科学界最广泛的使用。 JCVI计划的影响将被证明是非常高的，因为它解决了基础科学问题， 在预防和管理艾滋病毒/艾滋病方面的一些主要问题和挑战的解决办法 当今的传染病。