The J. Craig Venter Institute Genome Center for Infectious Diseases

在过去的21年里，J·克雷格·文特尔研究所(JCVI)将前沿基因组学方法应用于 生物学中的各种问题。通过测序技术的重大变化，重点是 维护建立强大的样本和数据处理基础设施以及计算分析 利用日益庞大和复杂的基因组和转录组数据集的工具。JCVI 传染病基因组中心(GCID)是围绕一个中心主题建立的--应用 以基因组学为基础的创新方法来研究病原体及其毒力、耐药性、 免疫逃避，以及与宿主和宿主微生物群的相互作用。JCVI GCID将 解决病原体生物学的关键问题，包括(除其他外)病毒的进化动力学 人类宿主和动物宿主，抗生素耐药性在细菌中的传播，寻找 新的抗真菌药物靶点，以及对恶性疟原虫感染疟疾免疫的基础。这个 假设驱动的研究项目将由一个技术核心和一个数据管理和 分析和资源传播(DMARD)核心。一个行政核心将确保有效 管理和集成计划组件，以充分利用共享 方法、样本和见解。将建立一个推广方案，以促进使用 其他机构和国家的基因组学。所有的数据、软件工具和繁重的资源将迅速 向公众公布，以支持科学界最广泛的使用。 JCVI计划的影响将被证明是非常高的，因为它解决了将 强调预防和管理中的一些主要问题和挑战的解决方案 今天的传染病。

For the past 21 years, the J. Craig Venter Institute (JCVI) has applied leading edge genomics approaches to diverse problems in biology. Through significant changes in sequencing technology, an emphasis has been maintained on establishing a robust sample and data handling infrastructure and computational analysis tools to take advantage of increasingly large and complex genomic and transcriptomic datasets. The JCVI Genomic Center for Infectious Diseases (GCID) is built around a central theme - the application of innovative genomics-based approaches to study pathogens and determinants of their virulence, drug-resistance, immune-evasion, and interactions with the host and the host microbiome. The JCVI GCID will address critical issues in pathogen biology including (among others), the evolutionary dynamics of viruses in human hosts and animal reservoirs, the dissemination of antibiotic resistance in bacteria, the search for novel antifungal drug targets, and the basis for immunity to malaria infection by Plasmodium falciparum. The hypothesis-driven Research Projects will be supported by a Technology Core and a Data Management and Analysis and Resource Dissemination (DMARD) Core. An Administrative Core will assure effective management and integration of the Program components so as to take best advantage of shared approaches, samples, and insights. An outreach program will be established to promote the use of genomics in other institutions and countries. All of the data, software tools, and strain resources will rapidly be made publicly available to support the broadest use by the scientific community. The impact of the JCVI Program will prove to be very high as it addresses the basic science issues that will underpin solutions to some of the major problems and challenges in the prevention and management of infectious diseases today.