ShEEP Request for Heidelberg Spectralis Tracking OCT System - HRA+OCT with OCT2 Multicolor

通过此申请，我们要求从ORD共享设备评估计划中获得资金 （SHEEP）购买新一代光学相干断层扫描（OCT）装置， 血管造影（OCT-A）功能。具体而言，我们寻求获得海德堡工程光谱 跟踪OCT系统- HRA+OCT w/OCT 2-多色和Heidelberg Engineering宽视野 成像模块。这一工具将在司法部的调查人员之间共享。 退伍军人事务中心的预防和治疗视力丧失（CPTVL）。 我们购买的理由是双重的。 首先，我们目前的OCT（海德堡工程HRA-OCT）正在变得过时， 升级到较新的OCT-A模式。二、新版Spectralis HRA-OCT仪器 与旧版本相比，它提供了几个科学优势，其中包括成像视网膜的能力。 在不需要将染料注射到动物体内的情况下， 提交此提案的调查人员均为爱荷华州市退伍军人事务中心的调查人员 视力丧失的预防和治疗。所有的调查人员都有兴趣发现 各种形式的视力丧失的原因，并开发新的视力丧失治疗方法，以帮助受影响的 老兵在视觉方面，提案中调查人员的研究组合是多样化的。 损失这些包括辐射引起的视网膜损伤、青光眼、与脑外伤有关的视力丧失 损伤，线粒体功能障碍，糖尿病视网膜并发症，视网膜外视力丧失，影像学 分析视网膜疾病和角膜损伤和功能障碍。 因此，使用OCT-A和多色分析采集海德堡光谱HRA+OCT将 提高爱荷华州VA市研究人员确定小鼠视力丧失原因的能力 通过视网膜成像。该仪器还将与我们的多学科 图像分析团队，这将使我们能够从每个图像中提取最大量的信息。 动物主题

With this application we request funds from the ORD Shared Equipment Evaluation Program (SHEEP) to purchase a new generation Optical Coherence Tomography (OCT) unit with OCT- angiography (OCT-A) capabilities. Specifically, we seek to obtain a Heidelberg Engineering Spectralis Tracking OCT System - HRA+OCT w/OCT2 – MultiColor and Heidelberg Engineering Widefield Imaging Module. This instrument will be shared among investigators within the Department of Veterans Affairs Center for the Prevention and Treatment of Visual Loss (CPTVL). The rationale for our purchase is twofold. First, our current OCT, a Heidelberg Engineering HRA-OCT is becoming outdated and cannot be upgraded to a newer OCT-A mode. Second, the new version of the Spectralis HRA-OCT instrument offers several scientific advantages over the older version, which include the ability to image retinal vasculature without the need to inject dye into the animal. The investigators that are submitting this proposal are all investigators within the Iowa City VA Center for the Prevention and Treatment of Visual Loss. All investigators are interested in discovering the causes of various forms of visual loss and developing new treatments for visual loss to help affected Veterans. The research portfolio of investigators within with proposal is diverse with respect to visual loss. These include radiation-induced retinal damage, glaucoma, visual loss related to traumatic brain injury, mitochondrial dysfunction, retinal complications of diabetes, outer retinal visual loss, image analysis of retinal diseases and corneal damage and dysfunction. Thus, acquisition of a Heidelberg Spectralis HRA+OCT with OCT-A and Multicolor analysis will enhance the ability of investigators at the Iowa City VA to determine the causes of visual loss in mice through retinal imaging. This instrument will also integrate seamlessly with our multi-disciplinary image analysis team, which will allow us to extract a maximum amount of information from each animal subject.