ShEEP Request for Heidelberg Spectralis Tracking OCT System - HRA+OCT with OCT2 Multicolor

通过此应用程序，我们向ORD共享设备评估计划申请资金 (SHEEP)购买新一代光学相干层析成像(OCT)单元，OCT- 血管造影术(OCT-A)能力。具体地说，我们寻求获得海德堡工程光谱 跟踪OCT系统-HRA OCT，带OCT2-多色和海德堡工程领域 成像模块。这份文书将在司法部内部的调查人员之间共享 退伍军人视力丧失防治中心(CPTVL)。 我们购买的理由有两个。 首先，我们目前的OCT，海德堡工程HRA-OCT正在过时，不能 升级到较新的OCT-A模式。第二，新版Spectralis HRA-OCT仪器 与旧版本相比，提供了几个科学上的优势，其中包括成像视网膜的能力 血管系统，而不需要向动物体内注入染料。 提交这份提案的调查人员都是爱荷华市退伍军人管理局的调查人员 用于预防和治疗视力损失。所有调查人员都有兴趣发现 各种形式视力丧失的原因和开发新的视力丧失治疗方法来帮助受影响的人 退伍军人。建议中的调查人员的研究组合在视觉上是不同的 损失。这些包括辐射引起的视网膜损伤、青光眼、与创伤性脑有关的视力丧失 损伤，线粒体功能障碍，糖尿病视网膜并发症，视网膜外视力丧失，图像 视网膜疾病与角膜损伤和功能障碍的分析。 因此，利用OCT-A和多色分析获取海德堡光谱HRA OCT将 提高爱荷华州爱荷华市研究人员确定小鼠视力丧失原因的能力 通过视网膜成像。该仪器还将与我们的多学科无缝集成 图像分析团队，这将使我们能够从每个 动物主题。

With this application we request funds from the ORD Shared Equipment Evaluation Program (SHEEP) to purchase a new generation Optical Coherence Tomography (OCT) unit with OCT- angiography (OCT-A) capabilities. Specifically, we seek to obtain a Heidelberg Engineering Spectralis Tracking OCT System - HRA+OCT w/OCT2 – MultiColor and Heidelberg Engineering Widefield Imaging Module. This instrument will be shared among investigators within the Department of Veterans Affairs Center for the Prevention and Treatment of Visual Loss (CPTVL). The rationale for our purchase is twofold. First, our current OCT, a Heidelberg Engineering HRA-OCT is becoming outdated and cannot be upgraded to a newer OCT-A mode. Second, the new version of the Spectralis HRA-OCT instrument offers several scientific advantages over the older version, which include the ability to image retinal vasculature without the need to inject dye into the animal. The investigators that are submitting this proposal are all investigators within the Iowa City VA Center for the Prevention and Treatment of Visual Loss. All investigators are interested in discovering the causes of various forms of visual loss and developing new treatments for visual loss to help affected Veterans. The research portfolio of investigators within with proposal is diverse with respect to visual loss. These include radiation-induced retinal damage, glaucoma, visual loss related to traumatic brain injury, mitochondrial dysfunction, retinal complications of diabetes, outer retinal visual loss, image analysis of retinal diseases and corneal damage and dysfunction. Thus, acquisition of a Heidelberg Spectralis HRA+OCT with OCT-A and Multicolor analysis will enhance the ability of investigators at the Iowa City VA to determine the causes of visual loss in mice through retinal imaging. This instrument will also integrate seamlessly with our multi-disciplinary image analysis team, which will allow us to extract a maximum amount of information from each animal subject.