2017 Plant Metabolic Engineering: Plant Engineering in the Synthetic Biology Era Gordon Research Conference and Gordon Research Seminar

2017植物代谢工程：合成生物学时代的植物工程戈登研究大会暨戈登研究研讨会

• 批准号: 9325628
• 负责人: Joseph Martin Jez
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9325628
• 关键词: Adopted; Automobile Driving; Back; Big Data; Biochemical; Biochemistry; Biological; Cellular biology; Chemicals; Communities; Complement; Computer Simulation; DNA; Engineering; Faculty; Failure; Food Supply; Funding Agency; Future; Generations; Genetic; Genomics; Goals; Government; Health; Human; Industry; Interdisciplinary Study; Knowledge; Metabolic Pathway; Metabolism; Methods; Microbe; Mission; Molecular Biology; Natural Products; New Hampshire; Nutritional; Organism; Ownership; Participant; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Phytochemical; Plant Components; Plants; Production; Property; Public Health; Research; Research Personnel; Research Project Summaries; Running; Science; Scientist; Standardization; System; Systems Biology; Talents; Thinking; Work; Writing; base; career; design; dietary supplements; fascinate; graduate student; grasp; meetings; member; metabolic engineering; microbial; next generation; novel therapeutics; nutrition; peer; programs; success; symposium; synergism; synthetic biology

PROJECT SUMMARY Research in plant metabolism has advanced rapidly since the advent of molecular biology, and has accelerated with the arrival of the omics/big data era. Engineering based on this research can contribute to the global bioeconomy by developing new drugs, generating green production platforms for feedstocks and fuels, and enhancing food supplies. Synthetic biology can greatly increase this potential, but its concepts and methods are not yet widespread in plant science. In essence, synthetic biology extends the metabolic engineering toolbox by adopting design concepts such as standardization and modularity, by devising non- natural pathways and products, and by exploiting computational simulation and DNA writing. Synthetic biology thus requires cross-disciplinary exchange. The Plant Metabolic Engineering GRC will bring together leading plant and microbial engineers, synthetic biologists, computational biochemists, and funding agency scientists. The program aims to: i) highlight how synthetic biology can repurpose metabolism; ii) present cutting-edge engineering and discovery research from the health and biobased economy sectors; iii) consider plants versus microbes as ‘chassis organisms’; and iv) discuss synthetic biology-enabled engineering from industry and government perspectives. Successful plant metabolic engineering requires input from researchers across a wide variety of fields. This GRC provides one of the only forums interactions among these diverse groups of scientists. Complementing the scientific mission is the GRC's commitment to engaging the next generation of scientists. As in the past, a two-day Gordon Research Seminar (GRS) for graduate students and postdoctorals will precede this GRC. The GRS allows graduate students and postdoctorals to present their work to peers, and to openly discuss current issues in the field and future directions. This combination allows GRS participants to establish ownership of a field, to form a community, and to organize and run a meeting venue of early career scientists. GRS participants will be expected to stay for the GRC, further enhancing the educational component of this conference. In addition, roughly 1/3 of the speakers in the 2017 GRC will either be junior faculty members presenting in programmed sessions or be graduate students, postdoctorals, or junior faculty speaking in a special 'rising stars' session.

项目摘要 自分子生物学出现以来，植物代谢的研究进展迅速， 随着组学/大数据时代的到来，基于这项研究的工程可以有助于 通过开发新药，为原料和燃料建立绿色生产平台， 增加粮食供应。合成生物学可以大大提高这种潜力，但其概念和 方法在植物科学中还不普遍。从本质上讲，合成生物学扩展了代谢生物学， 工程工具箱，采用标准化和模块化等设计理念， 自然途径和产物，并利用计算机模拟和DNA写入。合成生物学 这就需要跨学科的交流。植物代谢工程GRC将汇集领先的 植物和微生物工程师、合成生物学家、计算生物化学家和资助机构的科学家。 该计划旨在：i）突出合成生物学如何重新利用新陈代谢; ii）呈现尖端的 健康和生物经济部门的工程和发现研究; iii）考虑植物与 微生物作为“底盘有机体”;和iv）讨论来自工业的合成生物工程， 政府视角。 成功的植物代谢工程需要来自各个领域的研究人员的投入。这 GRC为这些不同的科学家群体提供了唯一的论坛之一。 作为对科学使命的补充，GRC致力于吸引下一代科学家。 和过去一样，为期两天的戈登研究研讨会（GRS）的研究生和博士后将 在这个GRC之前。GRS允许研究生和博士后向同行展示他们的工作， 公开讨论该领域的当前问题和未来方向。这种组合允许GRS参与者 建立一个领域的所有权，形成一个社区，并组织和运行一个早期职业生涯的会议场所 科学家预计GRS参与者将留在GRC，进一步加强教育 是这次会议的一部分。此外，2017年GRC中约有1/3的演讲者将是初级 在程序化会议中发言的教师，或者是研究生、博士后或初级教师 在一个特别的“新星”会议上发言。