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Reducing Variability in Hepatic Shear Wave Elastography

减少肝脏剪切波弹性成像的变异性

基本信息

批准号：
9269212
负责人：
Anthony Edward Samir
金额：
$ 19.74万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9269212
关键词：
Adoption Algorithms Anatomy Caring Characteristics Cirrhosis Clinical Clinical Trials Computer software Data Development Device Designs Devices Diagnosis Diffuse Disadvantaged Disease Disease Progression Doctor of Philosophy Early Diagnosis Etiology Faculty Fibrosis Funding Goals Heavy Drinking Hepatic Hepatology Infection Interobserver Variability Laboratories Liver Liver Fibrosis Liver diseases Measurement Measures Mentors Monitor Morbidity - disease rate Optics Outcome Pathway interactions Patients Polymers Positioning Attribute Process Radiology Specialty Reference Standards Research Research Personnel Risk stratification Skin Speed Staging Standardization Supervision System Technical Expertise Technology Time Tissues Training Programs Transducers Translations Ultrasonic Transducer Ultrasonography Validation Variant accurate diagnosis base career development chronic liver disease clinical practice computerized data processing cost design disease heterogeneity effective therapy elastography follow-up healing human subject improved interest liver biopsy liver injury liver transplantation mortality new technology nonalcoholic steatohepatitis performance tests prevent public health relevance sensor skills software development tissue regeneration validation studies

项目摘要

DESCRIPTION (provided by applicant): Shear wave elastography (SWE) of the liver is a new technology that has been shown to be useful for distinguishing early from advanced liver fibrosis. At present, interobserver variability limits the use of shear wave elastography for precise staging and serial monitoring of the progression of diffuse liver disease. The broad research goal of this proposal is to reduce shear wave elastography variability. The research has two specific aims. [Aim 1 is to create a new system - hardware and algorithms - by (1) integrating two previously developed systems: (a) a force-measurement (FM) ultrasound probe system, which measures and displays applied transducer force (preload) in real-time, permitting the operator to precisely control applied preload, and (b) an optical tracking system (OTS), which precisely localizes a transducer relative to skin markings, facilitating precise software-based co-registration of shear wave elastograms, and (2) creating new algorithms to process data generated by the integrated FM/OTS device.] In Aim 2 Dr. Samir will perform a clinical trial in thirty human subjects testing the performance of FM/OTS enhanced SWE against the reference standard of histopathologically staged liver fibrosis. Career development goals: Immediate and long-term. Dr. Samir's short-term goal is to acquire additional technical skills and advanced clinical trial skills through the combination of device design, fabrication, and software development under the guidance of MED- RC faculty, particularly Dr. Brian Anthony, and advanced clinical trial skills under the supervision of Raymond Chung MD, who is an expert in Hepatology research. Dr. Ralph Weissleder MD PhD and Dr. Bruce Rosen MD PhD, both well-known experts in Radiology research, will mentor Dr. Samir throughout his training program in order to facilitate his long-term objective, which is to become an independently funded investigator leading a laboratory focused on rapid development and translation of medical ultrasound technology.