Pesticide Exposure and Birth Outcomes

农药接触和出生结果

• 批准号: 9300665
• 负责人: Ondine von Ehrenstein
• 金额: $ 7.8万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9300665
• 关键词: Address; Adverse effects; Affect; Agriculture; Animals; Assessment tool; Biological Markers; Birth; Birth Records; Birth Weight; Blood; California; Carbamates; Case-Control Studies; Chemicals; County; Cues; Data; Data Reporting; Databases; Dimensions; Endocrine Disruptors; Endocrine disruption; Endocrine system; Event; Exhibits; Exposure to; Farming environment; Fetal Death; Fetal Growth; Fruit; Funding; Future; Geographic state; Geography; Gestational Age; Gestational Diabetes; Goals; Health Policy; Human; Hypertension; In Vitro; Locales; Low Birth Weight Infant; Maps; Methods; Newborn Infant; Organophosphates; Outcome; Patient Self-Report; Pesticides; Population; Population Study; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Premature Birth; Production; Property; Public Health; Records; Reporting; Resources; Risk; Risk Assessment; Sample Size; Sampling Studies; Spottings; Statistical Data Interpretation; System; Techniques; Time; United States National Institutes of Health; Weight; agricultural pesticide; base; cohort; cost efficient; design; epidemiology study; experience; experimental study; glyphosate; human data; infant death; insight; interest; land use; maternal serum; pesticide exposure; pollutant; population based; pregnancy hypertension; prenatal; prenatal exposure; prenatal health; pyrethroid

Abstract Few studies have been designed to assess impacts of prenatal pesticide exposures on adverse pregnancy events and outcomes including preterm birth and fetal growth. Earlier epidemiological studies were mainly relatively small case/control studies, with limited information about exposure relying on self-reported data that produced equivocal findings. Recently, reports emerged suggesting pregnancy complications such as gestational diabetes, or preeclampsia in relation to early pregnancy exposure to pesticides. Endocrine disrupting properties suggested for several classes of agricultural pesticides, have been proposed to contribute to increases in risks for adverse pregnancy events and birth outcomes. Thus a well-designed large scale population based study with detailed and reliable pesticide exposure assessment (not based on parental recall) is urgently needed. Our proposed study will address this gap in a highly efficient and timely manner, leveraging our existing resources established with funding from NIH, by combining sophisticated pesticide exposure assessment with large-scale population and record-based birth cohort data. California is an excellent locale for such a study: the state ranks 1st among US states in agricultural production, with 1/4 of US total agricultural pesticide use, and is the only state which maintains a statewide pesticide use reporting system. Building onto this unique resource, our team has longstanding experience developing and applying a geographic pesticide exposure assessment tool (GRAPES) that utilizes the unique California Pesticide Use Report system, in combination with agricultural land-use maps, to derive estimates of residential exposures to specific pesticides. We propose to conduct a records and population based study focused on the agricultural counties of California, including the Central Valley, one of the world’s most intensely farmed regions (the Nation’s “Fruit Basket”), using all births 1998-2013 (n>700,000) for which we will newly create detailed periconceptional/ prenatal and trimester specific pesticide exposure estimates. We will comprehensively assess risks for preterm birth, fetal growth indicators, fetal and infant death, and pregnancy complications (gestational diabetes, preeclampsia). This approach will provide the - to our knowledge - largest population based study with advanced exposure assessment not relying on self-report, to address the hypotheses that exposure to specific chemicals such as endocrine disrupting agents increase risk for adverse birth outcomes. For this study, we will focus on chemicals used in high volume, potential endocrine disrupters, and those previously found to have adverse effects in animal/human studies, including glyphosate, organophosphates, neonicotinoids, pyrethroids. Thus, leveraging the resources we previously created with NIH funding, this study will likely have high impact as it addresses public concerns about prenatal health effect of pesticide exposures, and has the potential to influence public health policies and future research in a highly cost-efficient manner. The design of future biomarker studies we plan, will build upon the findings of the proposed record-only study.

摘要 很少有研究被设计来评估产前农药暴露对不良妊娠的影响 事件和结局，包括早产和胎儿生长。早期的流行病学研究主要是 相对较小的病例/对照研究，关于暴露的信息有限，依赖于自我报告的数据， 得出了模棱两可的结论最近，有报告显示，怀孕并发症，如 妊娠期糖尿病或先兆子痫与怀孕早期接触农药有关。内分泌 破坏性能建议几类农药，已提出贡献 不良妊娠事件和分娩结局的风险增加。因此，精心设计的大规模 基于人群的研究，包括详细和可靠的农药暴露评估（不基于父母回忆） 是迫切需要的。我们拟议的研究将以高效和及时的方式解决这一差距， 我们现有的资源是由NIH提供资金建立的， 大规模人口和基于记录的出生队列数据的评估。加州是一个很好的地方， 这样一项研究：该州的农业产量在美国各州中排名第一，占美国农业总产量的1/4， 美国是唯一一个在全国范围内建立农药使用报告系统的州。建立在 这种独特的资源，我们的团队有长期的经验，开发和应用地理农药 暴露评估工具（GRAPES），该工具利用独特的加州农药使用报告系统， 与农业土地使用图相结合，得出居民接触特定农药的估计数。 我们建议进行一项以记录和人口为基础的研究，重点是以下农业县： 加州，包括世界上耕种最密集的地区之一的中央谷（国家“水果 篮子”），使用1998-2013年的所有出生（n> 700，000），我们将为此新创建详细的围概念/ 产前和孕期特定农药接触估计数。我们将全面评估早产风险 出生、胎儿生长指标、胎儿和婴儿死亡以及妊娠并发症（妊娠糖尿病， 先兆子痫）。据我们所知，这种方法将提供最大的基于人群的研究， 先进的暴露评估不依赖于自我报告，以解决暴露于特定的假设， 内分泌干扰剂等化学物质会增加不良分娩结果的风险。在这项研究中，我们将 重点关注大量使用的化学品，潜在的内分泌干扰物，以及那些以前发现有 在动物/人类研究中的不良反应，包括草甘膦，有机磷酸盐，烟碱类， 拟除虫菊酯因此，利用我们以前在NIH资助下创建的资源，这项研究可能会 具有很高的影响力，因为它解决了公众对农药暴露对产前健康影响的担忧， 以高成本效益的方式影响公共卫生政策和未来研究的潜力。的 我们计划的未来生物标志物研究的设计将建立在拟议的仅记录研究的结果之上。