Use of Novel Mobile Technology to Screen Sexual Partners for HIV and STIs

使用新型移动技术筛查性伴侣的艾滋病毒和性传播感染

• 批准号: 9270044
• 负责人: Ivan C Balan
• 金额: $ 58.05万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-05 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270044
• 关键词: Acquired Immunodeficiency Syndrome; Antibodies; Anus; Balan; Behavior; Behavioral; Biomedical Engineering; Blood; Blood Tests; Caring; Cellular Phone; Computers; Conscious; Detection; Development; Devices; Drops; Early treatment; Electronics; Empathy; Engineering; Epidemic; Feedback; Frequencies; Funding; HIV; HIV Infections; HIV Seropositivity; HIV/STD; Hand; Harm Reduction; Health; High Risk Woman; Home environment; Human immunodeficiency virus test; Incidence; Individual; Infection; Instruction; Intervention; Interview; Interviewer; LIF gene; Lead; Link; Methods; Monitor; Motivation; Newly Diagnosed; Participant; Phase; Phonation; Prevention; Prevention strategy; Recommendation; Research; Research Personnel; Risk; Risk Assessment; Schools; Sex Behavior; Sexual Partners; Shapes; Symptoms; Syphilis; Technology; Telephone; Test Result; Testing; Time; Universities; Use Effectiveness; Visit; Work; base; condoms; experience; high risk; high risk population; high risk sexual behavior; innovation; men; men who have sex with men; mobile computing; monitoring device; novel; novel strategies; pre-exposure prophylaxis; prevent; public health relevance; screening; seroconversion; sex risk; sexual encounter; skills; social norm; tool; transgender women; transmission process; usability

 DESCRIPTION (provided by applicant): Increasing incidence of HIV and STIs among men who have sex with men (MSM) and transgender women (TGW) highlight the need for novel approaches to reducing infections-especially among individuals who do not use condoms consistently. Our prior studies on the use of rapid HIV self-testing (ST) by MSM who regularly engage in high-risk sexual behavior, show that these men are willing to use ST with partners, avoid intercourse in situations where partners test HIV-positive, and, over time tend to reduce their high-risk sexual behavior. This proposed study expands this line of research by exploring the use of a new device, the mChip dongle. Developed at the Columbia University School of Engineering, this device uses smartphone technology to analyze a drop of blood and test it for HIV and syphilis antibodies. The mChip dongle brings more precision to ST, tests for HIV and syphilis and potentially other STIs, and can capitalize on smartphone technology to provide clearer user instructions, on-hand information about HIV/STI, remote monitoring of the its use, and linkage of newly diagnosed individuals to care. For this proposed quantitative and qualitative study, we will again focus on HIV-uninfected MSM and TGW with multiple sexual partners who know how to prevent HIV infection, yet engage in high-risk sexual behavior. The Specific Aims are to: 1) Assess acceptability among MSM and TGW of using the mChip dongle to test sexual partners; 2) Optimize the smartphone app and mChip dongle for home use; and 3) Assess the feasibility of using the mChip dongle to test sexual partners, including: a) frequency of use of the mChip dongle with sexual partners over 3 months; b) factors associated with mChip dongle use or non-use; c) condom use with partners who were not screened vs. partners screened HIV or STI- negative with the mChip dongle; and d) factors associated with changes in sexual risk behavior over 3 months. The study consists of two phases. In Phase 1A, 60 participants will undergo a quantitative, qualitative, and skill-demonstration assessment (using the mChip dongle in front of the interviewer) in a single study visit. Phase 1A findings wil inform Phase 1B, which focuses on revising the smartphone app and mChip dongle for home users, as well as revisions to the Phase 2 assessment. In Phase 2A, 80 new participants will undergo a baseline quantitative and skill-demonstration assessment in order to screen for 50 participants who will be invited into the Phase 2B 3-month study. These 50 participants will be provided with an mChip dongle and given the choice to use it to screen sexual partners. After 3 months participants will undergo a quantitative and qualitative interview about experiences using (or not using) the mChip dongle with partners. This study will capitalize on a critical juncture in the development of the mChip dongle by systematically engaging its intended users in offering feedback to the engineering team on how to optimize its usability and acceptability among high-risk populations. This study will also allow us to assess the feasibility of conducting a larger and longer trial to develop and test an mChip-based harm-reduction intervention.

 描述（由适用提供）：与男性发生性关系（MSM）和变性妇女（TGW）的男性中艾滋病毒和性传播感染事件的增加强调了需要减少感染的新方法，尤其是在不始终使用避孕套的人中。我们先前对经常从事高风险性行为的MSM使用快速艾滋病毒自我测试（ST）的研究表明，这些人愿意与伴侣使用ST，避免在伴侣测试HIV阳性的情况下进行性交，并且随着时间的流逝，他们倾向于减少他们的高风险性行为。这项拟议的研究通过探索新设备MCHIP加密狗的使用来扩展这一研究。该设备在哥伦比亚大学工程学院开发，使用智能手机技术来分析一滴血液并测试艾滋病毒和梅毒抗体。 MCHIP加密狗为ST，HIV和梅毒的测试以及潜在的其他性传播感染带来了更精确的精确度，并且可以利用智能手机技术，以提供更清晰的用户指导，有关HIV/STI的核对信息，远程信息对其使用以及新诊断的个人护理的链接。对于这项拟议的定量和定性研究，我们将再次专注于对艾滋病毒未感染的MSM和TGW，与多个知道如何预防艾滋病毒感染但从事高风险性行为的性伴侣。具体目的是：1）评估使用MCHIP加密狗测试性伴侣的MSM和TGW之间的可接受性； 2）优化智能手机应用程序和MCHIP加密狗供家庭使用； 3）评估使用MCHIP加密狗测试性伴侣的可行性，包括：a）在3个月内使用MCHIP加密狗与性伴侣使用的频率； b）与MCHIP加密狗使用或不使用相关的因素； c）与未经筛选的合作伙伴与伴侣筛查艾滋病毒或麦基普加密狗的否定的避孕套； d）与3个月内性风险行为变化相关的因素。该研究包括两个阶段。在第1A阶段，有60位参与者将在一次研究访问中进行定量，定性和技能示范评估（使用访调员前的MCHIP加密狗）。第1A阶段的发现WIL Infils 1B阶段，重点是修改家庭用户的智能手机应用程序和MCHIP加密狗，以及对第二阶段评估的修订。在第2A阶段，80名新参与者将接受基线定量和技能示范评估，以筛选50名参与者，这些参与者将被邀请参加2B期3个月研究。这50名参与者将配备MCHIP加密狗，并选择使用它来筛选性伴侣。 3个月后，参与者将接受定量和定性的访谈，以了解使用（或不使用）MCHIP加密狗与合作伙伴的经验。这项研究将通过系统地吸引其目标用户向工程团队提供有关如何优化高风险人群中其可用性和可接受性的反馈，从而利用MCHIP加密狗开发的关键关头。这项研究还将使我们能够评估进行更大且更长的试验以开发和测试基于MCHIP的损害干预措施的可行性。