THE SHARED GENETICS OF ALCOHOL-RELATED DISORDERS AND SCHIZOPHRENIA

摘要 严重的精神疾病和物质使用障碍经常同时发生。患有 精神分裂症--一种常见的、持久的、严重的精神疾病--酗酒的比率要高得多。 吸烟率和吸烟率均高于一般人群。同样，患有物质使用障碍的人经常遭受 免受其他精神疾病的伤害。例如，22%的酒精使用障碍患者有另一种精神疾病 疾病，相比之下，没有酒精使用障碍的人只有11%。尽管共病很普遍，但它 目前尚不清楚共同的遗传因素是否会导致精神分裂症和物质使用障碍。 在这项研究中，我们使用了现有的全基因组关联研究(GWAS)数据和最新的统计数据 评估精神分裂症是否与酒精使用障碍或尼古丁有共同遗传因素的方法学 依赖。具体地说，在目标1中，我们将评估导致精神分裂症的遗传因素 也会导致酒精使用障碍和尼古丁依赖。然后，在目标2中，我们将评估 导致酒精使用障碍或尼古丁依赖的遗传因素也会导致 精神分裂症。这一新的提议意义重大，因为它将导致对共病的更好理解 精神分裂症与酒精使用障碍和尼古丁依赖在基因水平上。

Abstract Severe mental illness and substance use disorder frequently co-occur. Individuals suffering from schizophrenia—a common, persistent, and severe mental illness—have much higher rates of heavy alcohol use and smoking than the general population. Similarly, individuals with substance use disorder often suffer from other mental illnesses. For example, 22% of individuals with alcohol use disorder have another mental illness, compared to 11% of individuals without alcohol use disorder. Despite the prevalence of comorbidity, it is not known whether shared genetic factors contribute to schizophrenia and substance use disorders. In this study, we use existing genome-wide association study (GWAS) data and state-of-the-art statistical methodology to evaluate whether schizophrenia shares genetic factors with alcohol use disorder or nicotine dependence. Specifically, in aim 1 we will evaluate whether genetic factors that contribute to schizophrenia also contribute to alcohol use disorder and to nicotine dependence. Then, in aim 2, we will evaluate whether genetic factors that contribute to either alcohol use disorder or nicotine dependence also contribute to schizophrenia. This novel proposal is significant because it will lead to improved understanding of comorbidity of schizophrenia with alcohol use disorder and with nicotine dependence at a genetic level.