Reduction of Nephrotoxic Medication-Associated Acute Kidney Injury in Children

 描述(申请人提供)：为了响应PAR-14-002(通过安全用药研究促进患者安全实施)，研究的总体目标是将我们成功的肾毒性药物相关的急性肾损伤减少项目推广到其他儿科医院。我们在辛辛那提儿童医院实施的“及时行动的肾毒性损害阴性”项目使130名患者避免了肾毒性AKI，一年内避免了900天的AKI。AIM 1将使用卫生保健改进研究所的突破系列方法将该项目传播到其他9家儿童医院。Aim 2将使用中断的时间序列方法来衡量忍者在这些医院的影响。目标3将使用定性比较分析来评估阻碍或促进忍者在每个机构现有的不同支助系统中传播的背景因素。

 DESCRIPTION (provided by applicant): In response to PAR-14-002 (Advancing Patient Safety Implementation through Safe Medication Use Research), the overall goal of study is disseminate our successful nephrotoxic medication associated acute kidney injury reduction project to other pediatric hospitals. Implementation of our "Nephrotoxic Injury Negative by Just-in-time Action (NINJA)" project at Cincinnati Children's Hospital resulted in avoidance of nephrotoxic AKI in 130 patients and 900 days of AKI avoided in one year. Aim 1 will use the Institute for Healthcare Improvement Breakthrough Series Approach to disseminate the project to 9 other children's hospitals. Aim 2 will measure the impact of NINJA in these hospitals using interrupted time series approaches. Aim 3 will use qualitative comparative analysis to assess the contextual factors that present barriers or facilitate dissemination of NINJA over the varied support systems present at each institution.