Reduction of Nephrotoxic Medication-Associated Acute Kidney Injury in Children

减少儿童肾毒性药物相关的急性肾损伤

• 批准号: 8853551
• 负责人: STUART L GOLDSTEIN
• 金额: $ 49.86万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8853551
• 关键词: Reduction; Nephrotoxic; Medication; Associated; Acute

 DESCRIPTION (provided by applicant): In response to PAR-14-002 (Advancing Patient Safety Implementation through Safe Medication Use Research), the overall goal of study is disseminate our successful nephrotoxic medication associated acute kidney injury reduction project to other pediatric hospitals. Implementation of our "Nephrotoxic Injury Negative by Just-in-time Action (NINJA)" project at Cincinnati Children's Hospital resulted in avoidance of nephrotoxic AKI in 130 patients and 900 days of AKI avoided in one year. Aim 1 will use the Institute for Healthcare Improvement Breakthrough Series Approach to disseminate the project to 9 other children's hospitals. Aim 2 will measure the impact of NINJA in these hospitals using interrupted time series approaches. Aim 3 will use qualitative comparative analysis to assess the contextual factors that present barriers or facilitate dissemination of NINJA over the varied support systems present at each institution.

 描述（由申请人提供）：为响应PAR-14-002（通过安全用药研究推进患者安全性实施），研究的总体目标是将我们成功的肾毒性药物相关急性肾损伤减少项目推广到其他儿科医院。我们在辛辛那提儿童医院实施的“及时采取行动，肾毒性损伤阴性（NINJA）”项目使130名患者避免了肾毒性阿基，一年内避免了900天的阿基。目标1将利用保健改善研究所突破系列方法向其他9家儿童医院传播该项目。目标2将使用中断的时间序列方法来衡量NINJA在这些医院的影响。目标3将使用定性比较分析来评估在每个机构的不同支持系统中存在的障碍或促进NINJA传播的背景因素。