Predoctoral Training: Innovative Technologies for Natural Products and CAM Research

博士前培训：天然产物创新技术和 CAM 研究

• 批准号: 8998341
• 负责人: Nadja B Cech
• 金额: $ 7.94万
• 依托单位: UNIVERSITY OF NORTH CAROLINA GREENSBORO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8998341
• 关键词: Natural Products; Research; Training; innovative technologies; pre-doctoral

 DESCRIPTION (provided by applicant): Natural products play an essential role in both alternative and conventional western medicine. Over 30% of the US population reports using complementary and alternative medicine (CAM) modalities, which include botanical natural products. Furthermore, approximately 50% of all new small molecule drug approvals in the United States over the past decade were based on natural product compounds. Trained biomedical researchers are needed to evaluate the chemical composition, activity, and mechanism of action of natural products that are employed therapeutically. Such scientific investigations are critical for the development of safe and effective strategies to use natural products for the improvement of health, and to prevent their misuse. The National Center for Complementary and Alternative Medicine (NCCAM, recently renamed NCCIH) recognizes this need in their 2011-2015 Strategic Plan, which highlights the importance of training in "key biomedical and behavioral research disciplines necessary for rigorous, state-of-the-art scientific investigation of CAM interventions, practices, and disciplines." The University of North Carolina at Greensboro (UNCG) is a unique and ideal location for such training to occur. Our PhD program in Medicinal Biochemistry emphasizes natural products and CAM research, and we have a strong collaborative network of faculty mentors with relevant, funded research programs. UNCG also boasts two established centers that support research related to CAM, the Center for Translational Biomedical Research and the Natural Products and Drug Discovery Center. To take advantage of the exceptional training environment at UNCG, we propose to establish a new T32 program that will support five predoctoral students who will conduct basic science research on natural products and CAM. Drawing upon a rich institutional culture of diversity at UNCG, this training program will emphasize the recruitment, retention, and success of students from diverse backgrounds. Training within our T32 program will be tailored to fit the needs of individual students, with different opportunities provided to those on academic and industrial career paths. A unique element of our program will be training in the application of cutting-edge technologies for the analysis of complex botanical mixtures. Trainees will receive hands-on instruction in this area, making use of our exceptional NMR and mass spectrometry facilities. Ultimately, our objective with the proposed T32 program is to produce scientists ready to transition into independent CAM- related careers in industry or academia. We will leverage our preexisting expertise in natural products research and our strong web of connections within the CAM community to develop a program that can efficiently achieve this outcome.

 产品描述（申请人提供）：天然产品在替代和传统西医中发挥着重要作用。超过30%的美国人口报告使用补充和替代医学（CAM）模式，其中包括植物天然产品。此外，在过去十年中，美国所有新的小分子药物批准中约有50%是基于天然产物化合物。需要训练有素的生物医学研究人员来评估用于治疗的天然产品的化学成分，活性和作用机制。这种科学研究对于制定安全有效的战略，利用天然产品改善健康，并防止其滥用至关重要。国家补充和替代医学中心（NCCAM，最近更名为NCCIH）在其2011-2015年战略计划中认识到了这一需求，该计划强调了“对CAM干预措施，实践和学科进行严格，最先进的科学调查所必需的关键生物医学和行为研究学科培训的重要性。“格林斯伯勒的北卡罗来纳州大学（UNCG）是进行这种培训的独特和理想的地点。我们的药物生物化学博士课程强调天然产物和CAM研究，我们有一个强大的教师导师与相关的，资助的研究项目的合作网络。UNCG还拥有两个支持CAM相关研究的中心，即转化生物医学研究中心和天然产品和药物发现中心。为了利用UNCG特殊的培训环境，我们建议建立一个新的T32计划，该计划将支持五名博士前学生，他们将对天然产品和CAM进行基础科学研究。在UNCG丰富的多样性机构文化的基础上，这个培训计划将强调来自不同背景的学生的招聘，保留和成功。我们的T32计划内的培训将根据个别学生的需求量身定制，为学术和工业职业道路上的学生提供不同的机会。我们计划的一个独特元素将是培训应用尖端技术分析复杂的植物混合物。学员将接受这方面的实践指导，利用我们卓越的NMR和质谱设施。最终，我们的目标与拟议的T32计划是生产科学家准备过渡到独立的CAM相关的职业生涯在工业或学术界。我们将利用我们在天然产品研究方面的现有专业知识和我们在CAM社区内强大的联系网络，开发一个可以有效实现这一结果的计划。