Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine Research

博士前培训：天然产物和中西医结合研究的创新技术

• 批准号: 10602735
• 负责人: Nadja B Cech
• 金额: $ 10.13万
• 依托单位: UNIVERSITY OF NORTH CAROLINA GREENSBORO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10602735
• 关键词: Integrative Medicine; Natural Products; Research; Training; innovative technologies; pre-doctoral

PROJECT SUMMARY Natural products (particularly botanical dietary supplements) are a billion-dollar industry in the US and continue to serve as an important source for the development of new therapeutics. Trained biomedical researchers are needed to evaluate the chemical composition, activity, and mechanism of action of medicinally used natural products. The National Center for Complementary and Integrative Health (NCCIH) recognizes this need in their 2016 Strategic Plan, with the stated goal to “support research training and career development opportunities to increase the number and quality of scientists trained to conduct rigorous, cutting-edge research on complementary and integrative health practices.” The University of North Carolina at Greensboro (UNCG) is a unique and ideal location for such training to occur. Our PhD program in Medicinal Biochemistry emphasizes natural products and integrative medicine research, and we have a strong collaborative network of faculty mentors with relevant research programs. UNCG participates in two major NCCIH funded centers that focus on rigorous scientific investigation of botanical natural products, the Center for High Throughput Functional Annotation of Natural Products and the Center of Excellence for Natural Product Drug Interaction Research. To leverage the exceptional training environment at UNCG, we propose to renew a productive T32 program that has just finished its first period of funding. Drawing on a rich institutional culture of diversity at UNCG, our T32 program provides training in the basic science of natural products and integrative medicine while emphasizing the recruitment, retention, and success of trainees from diverse backgrounds. The program is tailored to fit the needs of individual students, with different opportunities provided to those on academic and industrial career paths. A unique element of our program is training in the application of cutting-edge technologies for the analysis of complex botanical mixtures. Trainees receive hands-on instruction in this area, making use of our exceptional NMR and mass spectrometry facilities. Our objective is to prepare trainees to transition into independent, natural products related research careers. During its inaugural funding cycle, the program was highly successful towards this goal, with our three graduates securing research positions in the academic or private sector. Our trainees have also disseminated important research findings, with a total of 67 presentations at conferences and 23 publication coauthorships. With this renewal application, we build on these past successes and on our assessment outcomes to deliver a plan for student training that will ultimately advance research on the safe and effective use of natural products and integrative medicine.

项目概要 天然产品（特别是植物膳食补充剂）在美国是一个价值十亿美元的产业，并且仍在继续发展 成为开发新疗法的重要来源。训练有素的生物医学研究人员是 需要评估药用天然药物的化学成分、活性和作用机制 产品。国家补充和综合健康中心 (NCCIH) 认识到这一需求 他们的 2016 年战略计划，其既定目标是“支持研究培训和职业发展 有机会增加接受过严格、尖端研究训练的科学家数量和质量 关于补充和综合健康实践的研究。”北卡罗来纳大学格林斯博罗分校 （UNCG）是进行此类培训的独特且理想的地点。我们的药物生物化学博士课程 强调天然产物和综合医学研究，我们拥有强大的合作网络 具有相关研究项目的教师导师。 UNCG 参与了 NCCIH 资助的两个主要中心， 高通量中心专注于植物天然产物的严格科学研究 天然产物的功能注释和天然产物药物相互作用卓越中心 研究。为了利用 UNCG 卓越的培训环境，我们建议更新高效的 T32 该计划刚刚完成第一期资助。借鉴丰富的多元化制度文化 UNCG，我们的 T32 计划提供天然产物和综合医学基础科学的培训 同时强调来自不同背景的学员的招募、保留和成功。该计划 专为满足个别学生的需求而量身定制，为学术和学生提供不同的机会 工业职业道路。我们计划的一个独特元素是尖端应用的培训 复杂植物混合物分析技术。学员接受该领域的实践指导， 利用我们卓越的核磁共振和质谱设备。我们的目标是让学员做好准备 过渡到独立的、天然产品相关的研究职业。在其首个融资周期中， 该计划在实现这一目标方面取得了巨大成功，我们的三名毕业生在该领域获得了研究职位 学术或私营部门。我们的学员还传播了重要的研究成果，共有 67 项 在会议上发表演讲并与人合着 23 份出版物。通过此续订申请，我们建立在 这些过去的成功以及我们的评估结果，以制定学生培训计划，最终将 推进安全有效使用天然产物和中西医结合的研究。