Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs....

神经急症治疗试验 (NETT) 网络临床站点中心......

• 批准号: 9064852
• 负责人: DAVID W WRIGHT
• 金额: $ 24.69万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9064852
• 关键词: Accounting; Adult; Anesthesiology; Biological Markers; Biomedical Engineering; Caring; Childhood; Clinical Trials; Collaborations; Communities; Community Outreach; Discipline; Emergency Medicine; Emergency research; Emergency treatment; Enrollment; Ethics; Ethnic Origin; Faculty; Goals; Hospitals; Industry; Laboratories; Mentorship; Morbidity - disease rate; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neurology; Neuropsychology; Operative Surgical Procedures; Orthopedics; Pharmacology; Phase III Clinical Trials; Population Heterogeneity; Race; Radiology Specialty; Research; Research Activity; Research Ethics; Science; Spinal cord injury; Status Epilepticus; Stroke; Training Programs; Trauma; Traumatic Brain Injury; Vertebral column; clinical research site; community setting; experience; faculty mentor; member; mentoring community; mortality; nervous system disorder; neurosurgery; operation; student mentoring; suburb; treatment trial

DESCRIPTION (provided by applicant): The Emory Neurological Emergencies Treatment Trials - Southeastern Collaborative (NETT-SEC) is a productive member of the NETT network. The NETT-SEC has participated in all NETT trials and is in the top 1/3rd for enrollments in RAMPART, ALIAS, and ProTECT III, accounting for over 148 subjects enrolled into the NETT trials (as of 11/14/2011). The goal of the NETT-SEC is synchronous with the NETT's overall stated purpose: to conduct large streamlined phase III clinical trials in a broad spectrum of neurological emergencies in order to reduce the morbidity and mortality of neurological diseases. We have participated in all of the NETT studies and contributed pediatric and adult subjects from all races and ethnicities. The NETT-SEC has formed extensive and highly functional collaborations with emergency medicine, neurology, neurointensive care, interventional neuroradiology, radiology, neurosurgery, anesthesiology, trauma surgery, pharmacology, ethics, biomedical engineering, laboratory science, neuropsychology, neuro-ophthamology, orthopedics (spine), EMS, Industry (Banyan Biomarkers), and others. In addition, the NETT-SEC brings together an extensive array of high volume urban and suburban hospitals with a well-established track record of expertise and experience in conducting ground-breaking research in neurological emergencies in a multiracial region. AIMS: 1.Continue high enrollment of a diverse population of subjects in NETT-sponsored Clinical Trials; 2. Grow the NETT-SEC by expanding collaborations, training programs, student and faculty mentoring, and community outreach; 3. Facilitate neurological emergencies research by enhancing NETT operations, expanding the NETT research portfolio, contributing to the dialog on research ethics, and disseminating discoveries to the community. The NETT-SEC has a proven track record as a productive hub of the first NETT network and will continue to support the goals of the NETT and NINDS by conducting high quality, efficient. Phase III clinical trials in both academic and community settings.

描述（由申请人提供）：埃默里神经急诊治疗试验-东南合作（NETT- sec）是NETT网络的一个富有成效的成员。net - sec参与了所有的NETT试验，在RAMPART、ALIAS和ProTECT III的入组人数中排名前1/3，有超过148名受试者入组了NETT试验（截至2011年11月14日）。NETT- sec的目标与NETT的总体目标是同步的：在广泛的神经急症中进行大型简化的III期临床试验，以降低神经疾病的发病率和死亡率。我们参与了所有的NETT研究，并提供了来自所有种族和民族的儿科和成人受试者。net - sec与急诊医学、神经病学、神经重症监护、介入神经放射学、放射学、神经外科、麻醉学、创伤外科、药理学、伦理学、生物医学工程、实验室科学、神经心理学、神经眼科、骨科（脊柱）、EMS、工业（Banyan生物标志物）等学科建立了广泛而高效的合作关系。此外，net - sec还汇集了大量的城市和郊区医院，这些医院在多种族地区开展开创性的神经紧急情况研究方面拥有良好的专业知识和经验。目的:1。在net赞助的临床试验中，继续对不同人群的受试者进行高入组；2. 通过扩大合作、培训项目、学生和教师指导以及社区外展来发展net - sec；3. 通过加强NETT业务、扩大NETT研究组合、促进研究伦理对话和向社区传播发现，促进神经急症研究。net - sec作为第一个NETT网络的生产中心，拥有良好的记录，并将通过开展高质量，高效的工作，继续支持NETT和NINDS的目标。在学术和社区环境中进行III期临床试验。

项目成果

Impact of individual clinical outcomes on trial participants' perspectives on enrollment in emergency research without consent.

个体临床结果对试验参与者在未经同意的情况下参加紧急研究的看法的影响。

• DOI: 10.1177/1740774516677276
• 发表时间: 2017
• 期刊: Clinical trials (London, England)
• 作者: Whitesides,LouisaW;Baren,JillM;Biros,MichelleH;Fleischman,RossJ;Govindarajan,PrasanthiR;Jones,ElizabethB;Pancioli,ArthurM;Pentz,RebeccaD;Scicluna,VictoriaM;Wright,DavidW;Dickert,NealW
• 通讯作者: Dickert,NealW

Does experience matter? Implications for community consultation for research in emergency settings.

• DOI: 10.1080/23294515.2017.1308978
• 发表时间: 2017-04-01
• 期刊: AJOB empirical bioethics
• 作者: Scicluna, Victoria M;Ali, Mohammed K;Dickert, Neal W
• 通讯作者: Dickert, Neal W