Duke Claude D. Pepper Older Americans Independence Center

克劳德·D·佩珀公爵美国老年人独立中心

• 批准号: 9169614
• 负责人: MIRIAM C. MOREY
• 金额: $ 107.82万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9169614
• 关键词: Accelerometer; Acute; Adult; Aging; American; Area; Award; Caliber; Capsicum; Cells; Chronic; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Communities; Development; Educational Curriculum; Educational workshop; Elderly; Environment; Evolution; Faculty; Financial Support; Funding; Genetic; Geriatrics; Goals; Health; Human; Individual; Interdisciplinary Study; Intervention; Knowledge; Lead; Leadership; Life Experience; Literature; Longevity; Measurement; Measures; Mentorship; Methodology; Methods; Mission; Molecular; Molecular Profiling; NCI Scholars Program; Organ; Pathway interactions; Persons; Phenotype; Physiological; Pilot Projects; Positioning Attribute; Process; Psychosocial Factor; Research; Research Personnel; Research Project Grants; Research Training; Resources; Science; Scientific Advances and Accomplishments; Secure; Staging; Structure; System; Technology; Tissues; Training; Translational Research; Universities; Work; body system; career; career development; data integration; design; education research; experience; fascinate; frailty; functional decline; improved; innovation; insight; knowledge base; meetings; multidisciplinary; next generation; novel; physical model; prevent; programs; psychosocial; public health relevance; research study; resilience; response; stressor; success; systematic review; therapy development; training opportunity; translational approach; working group

PROJECT SUMMARY/ABSTRACT - Overall The Duke University Claude D. Pepper Older Americans Independence Center (Duke OAIC) will provide intellectual leadership, innovation, interdisciplinary research strategies, translational approaches, development of early investigators and a collaborative spirit in its theme: to understand and optimize physiologic reserve and physical resilience in older adults. The specific aims of the Duke OAIC are to support an integrated research program in our theme; to develop and evaluate new methods that advance the field of reserve and resilience; to develop the next generation of researchers who will become leaders in aging research related to the our theme; and to support pilot studies that lead to more definitive research studies related to our theme. The Duke OAIC has an experienced Leadership and Administrative Core in place that will direct OAIC activities. The Duke OAIC supports a Research Education Component (REC), Pilot/Exploratory Studies Core (PESC) and three resource cores: Molecular Measures Core, Physical Measures Core, and Analysis Core. The resource cores provide collaborative support to several externally funded projects, development projects, REC Scholars and PESC pilot studies. In addition, the Molecular Measures Core will develop new molecular profiling and systems pathway analyses to evaluate cellular, tissue and organ resiliencies and identify resilient phenotypes. The Physical Measures Core will develop innovative measurement approaches to resilience at the person level and support an annual Health Innovations Technology competition. The Analysis Core will develop and disseminate new biostatistical analytic methodologies to advance the study of resilience. The REC will coordinate delivery of an aging research curriculum to early investigators across the University through a network called the Duke Community of Scholars in conjunction with the Duke Clinical and Translational Science Award (CTSA) and provide a structure for individualized aging research mentorship. The PESC will facilitate the highest caliber pilot studies related to our theme. The Duke OAIC will use several innovative mechanisms to facilitate career development and enhancement of research capabilities, including the Data Integration Working Group, Research Colloquia on Reserve and Resilience, Pepper Scholars Program, Intervention Development for Elderly Adults (IDEA) workshops, the Pilot Studies workshops, Functional Assessment and Ambulatory Activity Monitoring workshops, Disparities Research Curriculum, shared research education and pilot studies with the CTSA, and inclusion of community representatives in the pilot study selection process.

项目总结/摘要-总体 杜克大学克劳德D.胡椒老年美国人独立中心（杜克OAIC）将 提供智力领导，创新，跨学科研究战略，翻译 方法，培养早期调查人员和合作精神， 了解并优化老年人的生理储备和身体弹性。具体 杜克OAIC的目标是支持我们的主题的综合研究计划;发展 并评估推进储备和恢复力领域的新方法;开发下一个 一代研究人员将成为与我们的主题相关的老龄化研究的领导者; 并支持试点研究，从而导致与我们的主题有关的更明确的研究。 杜克OAIC有一个经验丰富的领导和行政核心，将直接 OAIC的活动。杜克OAIC支持研究教育组件（REC）， 试点/探索性研究核心（PESC）和三个资源核心：分子措施核心， 物理测量核心和分析核心。资源核心提供协作支持 几个外部资助的项目，发展项目，REC学者和PESC试点 问题研究此外，分子测量核心将开发新的分子分析， 系统通路分析，以评估细胞、组织和器官的毒性，并识别 弹性表型物理测量核心将开发创新的测量 在人的层面上的复原力的方法，并支持每年的健康创新 技术竞争。分析核心将开发和传播新的生物统计 分析方法，以推进弹性研究。REC将协调交付 通过网络向整个大学的早期研究人员提供老龄化研究课程 称为杜克学者社区，与杜克临床和翻译 科学奖（CTSA），并提供个性化的老龄化研究导师的结构。 PESC将促进与我们的主题相关的最高水平的试点研究。杜克OAIC 将利用几种创新机制促进职业发展和提高 研究能力，包括数据集成工作组， 储备和弹性，胡椒学者计划，老年人干预发展 （IDEA）研讨会，试点研究研讨会，功能评估和门诊活动 监测讲习班、差异研究课程、共享研究教育和试点 与CTSA进行研究，并将社区代表纳入试点研究选择 过程