Immunology Core

免疫应答在预防传染病方面至关重要，疫苗是预防传染病的重要手段。 这是一个非常有效的预防这些疾病的方法。尽管取得了相当大的进展， 保护免受肠道感染和疟疾以及其他传染因子的免疫学相关因素 构成该UI 9应用的一部分的信息仍然未知。为了解决这些知识上的重大差距，我们将 建立一个免疫学核心，将产生独特的免疫学数据， 微生物组、恶性疟原虫、霍乱弧菌、ETEC和其他研究产生的独特测序数据 在U19申请中提出，以解决宿主-寄生虫相互作用的未探索和关键的新方面。 免疫学核心的PI和他的团队在免疫反应的研究方面非常有经验 在人类和动物模型中使用最新技术开发感染因子和疫苗 技术和仪器。

Immune responses are of paramount importance in protection from infectious diseases and vaccines are an exceedingly cost-effective measure to prevent these illnesses. Despite considerable progress, the immunological correlates of protection from enteric infections and malaria, as well as other infectious agents that form part of this Ul 9 application remain unknown. To address these major gaps in knowledge, we will establish an Immunology Core that will generate unique immunological data to be correlated with microbiome, P. falciparum, V. cholerae, ETEC and other unique sequencing data resulting from studies proposed in this U19 application to address unexplored and critical new aspects of host-parasite interactions. The PI of this Immunology Core and his team are extremely experienced in the study of immune responses to infectious agents and vaccine development in humans and animal models using state-of-the-art techniques and instrumentation.