Immunology Core

免疫反应在预防传染病方面至关重要，而疫苗是 预防这些疾病的极具成本效益的措施。尽管取得了相当大的进展，但 预防肠道感染和疟疾以及其他感染源的免疫学相关性 该UL-9应用程序中形成的部分仍然未知。为了解决这些知识上的重大差距，我们将 建立一个免疫学核心，它将生成与之相关的唯一免疫学数据 微生物组、恶性疟原虫、霍乱弧菌、ETEC和其他研究产生的独特测序数据 在这份U19申请中提出，以解决宿主-寄生虫相互作用的未探索和关键的新方面。 这个免疫学核心的PI和他的团队在免疫反应的研究方面非常有经验 在人类和动物模型中使用最先进的传染病病原体和疫苗开发 技术和仪器。

Immune responses are of paramount importance in protection from infectious diseases and vaccines are an exceedingly cost-effective measure to prevent these illnesses. Despite considerable progress, the immunological correlates of protection from enteric infections and malaria, as well as other infectious agents that form part of this Ul 9 application remain unknown. To address these major gaps in knowledge, we will establish an Immunology Core that will generate unique immunological data to be correlated with microbiome, P. falciparum, V. cholerae, ETEC and other unique sequencing data resulting from studies proposed in this U19 application to address unexplored and critical new aspects of host-parasite interactions. The PI of this Immunology Core and his team are extremely experienced in the study of immune responses to infectious agents and vaccine development in humans and animal models using state-of-the-art techniques and instrumentation.