ShEEP IC Request to purchase MAGNETOM 7T PTx upgrade

我们正在申请为我们的Siemens 7 T MRI扫描仪升级Siemens ESTOM 7 T PTx。升级 将集成到SFVAMC现有的西门子7 T MRI扫描仪中。没有可选 组件和所有组件必须在系统的正常操作中同时使用。以下 通过此次升级提供了软件/硬件组件： · 8通道并行传输功能（版本步骤2.3） ·额外的电子机柜，带有8个独立的实时顺序控制器 · 32通道接收，8通道发射PTx线圈 ·主机许可证 ·从机许可证 · Z420主机 · Z420从机 西门子7 T MRI扫描仪的8个发射通道并行发射阵列（PTx）功能将 在交付时提供最新的软件和硬件发布版本。西门子将提供 硬件、软件、安装和集成。PTx升级是一个接口，可以连接到所包含的Siemens 产品32通道接收，8通道发射线圈，允许施加单独的RF激励脉冲 到多达8个发射线圈元件。在每个通道上，RF幅度、相位、频率和脉冲形状可以 独立应用。这使得B1传输空间均匀性得到显著改善， 与原来的单通道传输系统相比，可实现高质量、大视野的脑部和身体扫描。 PTx升级还允许比吸收率（SAR）降低高达~ 50%， 成像速度加速2倍的额外因素（Homann等MRM 2011; Wu等ISMRM 2017）。 随着下一代西门子7 T Terra系统预计将很快获得FDA批准， 临床使用，升级我们的7 T系统，以匹配未来Terra的8通道并行传输能力 系统是必要的VA保持在研究的前沿。7 T PTx升级将促进 开拓退伍军人健康的新临床应用，包括但不限于： 创伤性脑损伤（TBI）、创伤后应激障碍（PTSD）、创伤后骨关节炎（PTOA）、 慢性疼痛，精神分裂症，成瘾，抑郁症，甚至心血管疾病。我们要求这8 通道PTx功能，作为我们7 T系统的升级，使其成为唯一具有PTx功能的7 T MRI系统 在整个北方加州。至关重要的是，这种PTx升级不仅会改善我们的整个大脑神经成像， 能力，例如较低的比吸收率（SAR）和提高质量的均匀性，但它 还将扩展我们系统的功能，超越神经成像，并使尖端的超高场身体， 心脏和肌肉骨骼研究。资助这项提案将大大增加领先的退伍军人事务部研究 用于超高场MRI的设备，并帮助VA保持在成像技术发展的最前沿 和临床应用，从而帮助退伍军人患有疾病，诊断工具还没有 足够的或可用的。

We are requesting the Siemens MAGNETOM 7T PTx upgrade for our Siemens 7T MRI scanner. The upgrade will be integrated into our existing Siemens 7T MRI scanner at the SFVAMC. There are no optional components and all components must be used simultaneously in normal operation of the system. The following software / hardware components are provided through this upgrade: • 8 channel parallel transmit functionality (version step 2.3) • Additional electronic cabinet with 8 independent real-time sequence controllers • 32 channel receive, 8 channel transmit PTx coil • Licenses for Master computer • Licenses for Slave computer • Z420 Master computer • Z420 Slave computer Parallel transmit array (PTx) functionality with 8 transmit channels for the Siemens 7T MRI scanner will be provided with the latest software and hardware released version at the point of delivery. Siemens will provide the hardware, software, installation, and integration. The PTx upgrade is an interface to the included Siemens product 32-channel receive, 8-channel transmit coil, which allows separate RF excitation pulses to be applied to up to 8 transmit coil elements. On each channel, RF amplitudes, phases, frequencies, and pulse shapes can be independently applied. This allows for dramatic improvement in B1-transmit spatial homogeneity compared to the original 1-channel transmit system and enables high quality, large field-of-view brain and body scans. The PTx upgrade also allows for Specific Absorption Rate (SAR) reductions by as much as ~50%, allowing for an additional factor of two acceleration in imaging speed (Homann et al MRM 2011; Wu et al ISMRM 2017). With the next generation Siemens 7T Terra system expected to be released soon with FDA approval for clinical use, upgrading our 7T system to match the 8-channel parallel transmit capability of future Terra systems is necessary for the VA to remain at the forefront of research. The 7T PTx upgrade will facilitate the pioneering of new clinical applications for veteran health across the spectrum, including but not limited to: traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), post-traumatic osteoarthritis (PTOA), chronic pain, schizophrenia, addiction, depression, and even cardiovascular disease. We are requesting this 8 channel PTx capability as an upgrade to our 7T system to make it the only 7T MRI system with PTx capability in all of northern California. Critically, not only would this PTx upgrade improve our whole brain neuroimaging capabilities, e.g. lower specific absorption rate (SAR) and improved homogeneity of quality throughout, but it would also expand our system's capability beyond neuroimaging and enable cutting-edge ultra-high field body, cardiac, and musculoskeletal research. Funding this proposal would greatly augment the leading VA research facility for ultra-high field MRI and help keep the VA at the cutting edge of imaging technology development and clinical applications, thereby helping veterans afflicted with disease for which diagnostic tools are not yet adequate or available.