ShEEP IC Request to purchase MAGNETOM 7T PTx upgrade

我们要求为我们的西门子7T磁共振扫描仪升级西门子Magnetom 7T PTX。升级 将集成到我们SFVAMC现有的西门子7T磁共振扫描仪中。没有可选的 在系统的正常运行中，组件和所有组件必须同时使用。以下是 通过此次升级提供软件/硬件组件： ·8通道并行传输功能(版本步骤2.3) ·额外的电子机柜，配有8个独立的实时顺序控制器 ·32路接收，8路发送PTX线圈 ·主计算机许可证 ·从属计算机的许可证 ·Z420主计算机 ·Z420从机 具有8个传输通道的并行传输阵列(PTX)功能将用于西门子7T磁共振扫描仪 在交付时提供最新发布的软件和硬件版本。西门子将提供 硬件、软件、安装和集成。PTX升级是与包括西门子在内的 产品32通道接收，8通道发射线圈，允许施加单独的RF激励脉冲 最多8个传输线圈元件。在每个通道上，RF幅度、相位、频率和脉冲形状可以 独立应用。与之相比，这使得B1传输的空间均匀性得到显著改善 与原来的单通道传输系统相比，它可以实现高质量、大视场的脑部和身体扫描。 PTX升级还允许比吸收率(SAR)降低高达50%，允许 成像速度加速两倍的额外因素(Homann等人MRM 2011年；Wu等人ISMRM 2017年)。 下一代西门子7T Terra系统预计将很快发布，FDA将批准 临床应用，升级我们的7T系统以匹配未来Terra的8通道并行传输能力 系统对于退伍军人管理局保持在研究前沿是必要的。7T PTX升级将促进 为老兵健康领域开创新的临床应用，包括但不限于： 创伤性脑损伤(TBI)、创伤后应激障碍(PTSD)、创伤后骨关节炎(PTOA)、 慢性疼痛、精神分裂症、成瘾、抑郁，甚至心血管疾病。我们在此请求8 渠道PTX功能作为我们7T系统的升级，使其成为唯一具有PTX功能的7T MRI系统 在整个北加州。关键的是，PTX的升级不仅会改善我们的整个大脑神经成像 功能，例如更低的特定吸收率(SAR)和改进的质量一致性，但它 还将扩展我们系统的能力，使其超越神经成像，并使尖端的超高场强身体， 心脏和肌肉骨骼研究。资助这项提案将极大地增强退伍军人管理局的领先研究 超高场磁共振成像设备，使退伍军人管理局保持在成像技术发展的前沿 和临床应用，从而帮助患有尚未获得诊断工具的疾病的退伍军人 足够的或可用的。

We are requesting the Siemens MAGNETOM 7T PTx upgrade for our Siemens 7T MRI scanner. The upgrade will be integrated into our existing Siemens 7T MRI scanner at the SFVAMC. There are no optional components and all components must be used simultaneously in normal operation of the system. The following software / hardware components are provided through this upgrade: • 8 channel parallel transmit functionality (version step 2.3) • Additional electronic cabinet with 8 independent real-time sequence controllers • 32 channel receive, 8 channel transmit PTx coil • Licenses for Master computer • Licenses for Slave computer • Z420 Master computer • Z420 Slave computer Parallel transmit array (PTx) functionality with 8 transmit channels for the Siemens 7T MRI scanner will be provided with the latest software and hardware released version at the point of delivery. Siemens will provide the hardware, software, installation, and integration. The PTx upgrade is an interface to the included Siemens product 32-channel receive, 8-channel transmit coil, which allows separate RF excitation pulses to be applied to up to 8 transmit coil elements. On each channel, RF amplitudes, phases, frequencies, and pulse shapes can be independently applied. This allows for dramatic improvement in B1-transmit spatial homogeneity compared to the original 1-channel transmit system and enables high quality, large field-of-view brain and body scans. The PTx upgrade also allows for Specific Absorption Rate (SAR) reductions by as much as ~50%, allowing for an additional factor of two acceleration in imaging speed (Homann et al MRM 2011; Wu et al ISMRM 2017). With the next generation Siemens 7T Terra system expected to be released soon with FDA approval for clinical use, upgrading our 7T system to match the 8-channel parallel transmit capability of future Terra systems is necessary for the VA to remain at the forefront of research. The 7T PTx upgrade will facilitate the pioneering of new clinical applications for veteran health across the spectrum, including but not limited to: traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), post-traumatic osteoarthritis (PTOA), chronic pain, schizophrenia, addiction, depression, and even cardiovascular disease. We are requesting this 8 channel PTx capability as an upgrade to our 7T system to make it the only 7T MRI system with PTx capability in all of northern California. Critically, not only would this PTx upgrade improve our whole brain neuroimaging capabilities, e.g. lower specific absorption rate (SAR) and improved homogeneity of quality throughout, but it would also expand our system's capability beyond neuroimaging and enable cutting-edge ultra-high field body, cardiac, and musculoskeletal research. Funding this proposal would greatly augment the leading VA research facility for ultra-high field MRI and help keep the VA at the cutting edge of imaging technology development and clinical applications, thereby helping veterans afflicted with disease for which diagnostic tools are not yet adequate or available.