ShEEP-IC: Request to purchase MAGNETOM Skyra 3T complete concurrent field monitoring and motion correction system upgrade

我们正在申请资金购买完整的同步现场监测和运动校正系统 升级我们的EQUIPTOM Skyra 3 T扫描仪，预算报价为816，370美元（请参阅 13_VA_Quidix_3_Quote.pdf）。此升级包括两个主要组件， 同时用于扫描空间分辨率、鲁棒性和质量的协同改进。 Siemens 3 T Skyra MRI扫描仪的升级： 1. Kineticor运动校正系统，KC-3 T70（132，500美元） 2. Skope Complete并发监控系统（683，870美元） Kineticor运动校正系统使用一个低姿态的四摄像头系统来监控和校正 在MRI扫描采集期间，患者头部运动处于真实的时间。这是通过反馈运动来实现的 通过TR向扫描仪提供估计值，以更新成像梯度以及TR上的RF频率和相位 基础Skope Complete并行监测系统使用16个现场探头来测量和校正 伪影引起主磁场中的动态波动（例如，由于呼吸、头部运动或其他 MRI系统缺陷）。Skope Complete系统包括Neurocam（专用RF头部线圈 与16个现场探头集成）以及夹式摄像头（一套单独的16个现场探头） 希望使用现有Siemens射频头线圈进行同步监测的患者。 至关重要的是，拟议的升级不仅将促进整个大脑的非侵入性成像， 这是前所未有的空间分辨率，但它也将允许具有挑战性的患者的强大，高质量的成像 人群-包括难以保持静止的人群（如儿童、老年人和神经系统疾病患者） 疾病）以及倾向于产生生理上引起的图像伪影（例如， 肥胖患者和呼吸模式不规则的患者）。因此，现有的研究项目也将 节省时间和成本，因为较少的受试者数据会丢失或由于不良 图像质量为这项建议提供资金也将大大加强我们目前为征聘高质量的 教师候选人以及努力吸引跨机构的合作者，这有助于保持VA在 尖端的成像技术开发和临床应用-最终支持退伍军人 患有神经系统（TBI）和精神疾病（PTSD）的患者， 诊断工具尚不可用。

We are requesting funds to purchase complete concurrent field monitoring and motion correction system upgrade for our MAGNETOM Skyra 3T scanner at a budgetary quote of $816,370 (see 13_VA_Appendix_3_Quote.pdf). This upgrade comprises of two main components that will be used simultaneously for synergistic improvements to scan spatial resolution, robustness and quality. Upgrades for the Siemens 3T Skyra MRI scanner: 1. Kineticor Motion Correction System, KC-3T70 ($132,500) 2. Skope Complete Concurrent Monitoring System ($683,870) The Kineticor Motion Correction System uses a low profile, quad camera system to monitor and correct for patient head motion in real time during the MRI scan acquisition. This is achieved by feeding back the motion estimates to the scanner to update the imaging gradients as well as RF frequency and phase on TR by TR basis. The Skope Complete Concurrent Monitoring System uses 16 field probes to measure and correct for artifact inducing dynamic fluctuations in the main magnetic field (e.g. due to respiration, head motion, or other MRI system imperfections). The Skope Complete system includes the Neurocam (a dedicated RF head coil integrated with the 16 field probes) as well as the Clip-on Camera (a separate set of 16 field probes) for users who wish to perform concurrent monitoring with their existing Siemens RF head coils. Critically, not only would the proposed upgrade facilitate non-invasive imaging of the whole brain at unprecedented spatial resolutions, but it would also allow for robust, high quality imaging of challenging patient populations - including those who have difficulty keeping still (e.g. children, elderly, and those with neurological disorders) as well as those who are prone to generate physiologically induced image artifacts (e.g. large, obese patients and those with irregular breathing patterns). As such, existing research projects would also reap both time and cost savings since fewer subjects’ data would be lost or need to be re-acquired due to poor image quality. Funding this proposal would also greatly augment our ongoing efforts to recruit high-quality faculty candidates as well as efforts to attract cross-institution collaborators, which help keep the VA at the cutting edge of imaging technology development and clinical applications - ultimately supporting veterans afflicted with disease, such as neurological (TBI) and psychiatric (PTSD) disorders, for whom adequate diagnostic tools are not yet available.