Developmental Research Program

发展研究计划

• 批准号: 9763478
• 负责人: THOMAS BURKE
• 金额: $ 1.75万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9763478
• 关键词: Address; Award; Basic Science; Budgets; Cancer Biology; Cancer Patient; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communities; Community Developments; Development; Discipline; Doctor of Medicine; Doctor of Philosophy; Early Diagnosis; Educational Activities; Endometrial; Endometrial Carcinoma; Financial Support; Fostering; Funding; Future; Genomics; Goals; Gynecologic; Gynecology; Human; Incidence; Intervention; Laboratories; Lead; Letters; Malignant Neoplasms; Methodology; MicroRNAs; Nature; Outcome; Pathology; Pilot Projects; Plant Roots; Prevention; Prevention strategy; Process; Program Research Project Grants; Quality of life; Research; Research Personnel; Research Project Grants; Resources; Rest; Scientist; Signal Transduction; Translational Research; Uterine Cancer; Work; anticancer research; base; effective therapy; flexibility; high risk; improved; improved outcome; innovation; instrumentation; mortality; novel; professor; programs; recruit; sound; success; translational scientist; translational study

Developmental Research Program SUMMARY/ ABSTRACT The purpose of the Developmental Research Program (DRP) is to fund promising projects by investigators whose current work may not focus exclusively on endometrial cancer, but who propose highly innovative translational studies of endometrial cancer that could become full SPORE projects or compete successfully for funding outside of the SPORE mechanism. The DRP provides a unique venue for making available significant financial support, and for demonstrating active institutional support, through a program that is rapidly responsive to new ideas or initiatives. Moreover, this program is rooted in a spirit of collaboration espoused by the SPORE investigators, who have an extensive track-record of bringing investigators from other disciplines into the field of endometrial cancer research. The strength of the Developmental Research Program rests in its ability to make available financial support and access all the critical expertise and resources within the entire SPORE, including SPORE Cores. This will allow us to develop important collaborative, multi-investigator, multi- institutional research projects with the support of innovative, investigator-initiated projects that have the potential to flourish into reliable and productive translational research projects for the SPORE. Pre-proposals in the form of 1 page letters of intent will be solicited by the Program, and applicants with pre-proposals that are highly competitive for the goals of this program will be invited to submit a full proposal for review. The DRP Directors will help investigators submitting proposals to formulate relevant translational research aims and plans, as many applicants may not have prior expertise in this type of research. This process will therefore be a major educational activity that is further anticipated to stimulate translational research in endometrial cancer and encourage the participation of both basic science researchers and clinical investigators in translational research. The DRP will be led by Thomas Burke, M.D., the founding Endometrial Cancer SPORE PI and current Vice President of the MD Anderson Cancer Network, and Wei Zhang, Ph.D., a Professor in the Department of Pathology with specific expertise in cancer biology, genomics, and construction of miRNA signaling networks. Russell Broaddus, M.D., Ph.D., SPORE Co-PI, will provide oversight to the DRP. The DRP is critical to the continued success of the SPORE, as shown by four former DRP awardees now involved as research project Co-PIs in this application, and a fifth is an important co-investigator on a SPORE project. Two other former DRP awardees will provide their scientific expertise by serving on the External Advisory Board.

开发研究计划概要/摘要 发展研究计划（DRP）的目的是资助研究人员有前途的项目 他目前的工作可能并不完全集中在子宫内膜癌上，但他提出了高度创新的建议， 子宫内膜癌的转化研究，可以成为完整的孢子项目或竞争成功， 融资机制之外的融资。DRP提供了一个独特的场所， 财政支持，并通过一项迅速实施的计划， 对新的想法或倡议作出反应。此外，该计划植根于合作精神， SPORE调查人员，他们有着从其他学科引进调查人员的广泛记录 子宫内膜癌的研究领域。发展研究计划的优势在于其 能够提供财政支持，并获得整个系统内的所有关键专业知识和资源 孢子，包括孢子核心。这将使我们能够开发重要的协作，多调查员，多- 机构研究项目与创新的支持下，创业者发起的项目，有 潜力蓬勃发展成为可靠和富有成效的转化研究项目的孢子。预先提案 该计划将以1页的意向书形式征求申请人， 对于本计划的目标具有高度竞争力的将被邀请提交一份完整的建议书进行审查。的drp 主任将帮助研究者提交建议，以制定相关的翻译研究目标， 计划，因为许多申请人可能没有这种类型的研究事先的专业知识。因此，这一进程将是 一项重大的教育活动，预计将进一步促进子宫内膜癌的转化研究 并鼓励基础科学研究人员和临床研究人员参与翻译 research. DRP将由医学博士托马斯伯克领导，子宫内膜癌的创始人SPORE PI和 现任MD安德森癌症网络副总裁，张伟博士，的教授 病理学系，在癌症生物学、基因组学和miRNA构建方面具有特定专长 信令网络拉塞尔·布罗德斯，医学博士，哲学博士、SPORE Co-PI将对DRP进行监督。的 DRP对于SPORE的持续成功至关重要，四位前DRP获奖者现在参与其中 作为研究项目的合作PI在这个应用程序中，第五个是一个重要的合作研究者对一个孢子项目。 另外两名前DRP获奖者将通过担任外部顾问提供他们的科学专业知识 纸板.