Core B: Neuroscience Core

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Summary / Abstract The objective of the current program is to advance our understanding of the molecular and neurocircuitry mechanisms within the brain that control cardiovascular function and energy metabolism. The Neuroscience Core is designed to provide critical equipment and technical support for studying neural mechanisms affecting cardiovascular and metabolic functions that will be employed by all four projects within the program. Investigators will have a full access to an array of equipment through this core to achieve the goal of proposed studies that involve brain-region-specific gene manipulation, chemogenetic approach, multi-fiber recording of regional sympathetic nerve activity, and histological examination of the brain. In addition, the Directors and core staff will provide all necessary surgical support and training for all projects. The centralization of these endpoints into a core will ensure scientific rigor and reproducibility of all proposed experiments that will use advanced neuroscience techniques across the program.