ABCD Workshop on Brain Development in Relation to Mental Health

ABCD 大脑发育与心理健康关系研讨会

• 批准号: 9751007
• 负责人: Kathryn L Mills
• 金额: $ 11.16万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9751007
• 关键词: Area; Attention; Brain; Brain imaging; Child Rearing; Classification; Clinical; Code; Collaborations; Communities; Competence; Data; Data Analyses; Data Set; Development; Diagnostic; Dimensions; Educational process of instructing; Educational workshop; Environment; Environmental Risk Factor; Financial Hardship; Fostering; Funding; Goals; Immersion Investigative Technique; Instruction; Investigation; Knowledge; Learning; Magnetic Resonance Imaging; Mental Health; Methodology; Methods; Outcome; Paper; Participant; Psychopathology; Publishing; Reproducibility; Request for Applications; Research; Research Personnel; Scholarship; Scientist; Structure; Techniques; Training; Work; base; career; design; disability; hackathon; neuroimaging; online repository; open data; predictive modeling; recruit; skills; social; social inequality; symposium; theories; tool

Project Summary/Abstract Abstract: This project will fund a five-day immersive workshop that will prepare junior and senior researchers alike to utilize the ABCD data for investigations of brain development in relation to mental health. The workshop will focus on training researchers on reproducible neuroimaging methods, predictive modeling approaches, and clinical mental health outcomes, with equal emphasis on theory and application. The workshop will be composed of instructional, tutorial, roundtable, break-out session, and open hacking components. Workshop attendees will immediately apply what they learn during the workshop by competing in a hackathon challenge to develop classification tools for mental health related outcomes based on brain imaging data, with attention to relevant social and environmental factors. The main outcome of this workshop will be that researchers leave with answers to questions about analyzing ABCD data with newly developed tools, with a deeper understanding of the theory behind these tools as well as analytic considerations for highly dimensional data. This will include training on methodological considerations regarding clinical outcomes and fostering collaboration between computational and clinical researchers across career stages. Another principal aim of this workshop is to contribute to national efforts to diversify the pool of highly trained biomedical researchers by recruiting a diverse group of attendees by eliminating participation barriers associated with social inequality, including financial burden, parenting, or disability, and by creating a safe and welcoming environment during the workshop. The immediate goal of this workshop is for attendees to acquire the following competencies: a) knowledge of analytical and statistical considerations specific to large, open datasets; b) how to conduct reproducible research, with emphasis on neuroimaging; c) knowledge of theory behind predictive modeling and ability to apply newly developed tools; d) design and execute investigations with clinically meaningful outcomes; e) identify social and environmental factors that impact the development of psychopathology; and f) communicate with researchers from diverse backgrounds and build interdisciplinary teams. The dissemination goals of the proposed workshop include publishing papers, presenting at conferences, and making any code or analytic techniques developed during the workshop available in online repositories for the broader research community. A long- term goal of this workshop is to form sustainable interdisciplinary networks between researchers from development, clinical, and computational backgrounds as these areas of expertise are all needed to advance our understanding of mental health.

项目总结/摘要 翻译后摘要：该项目将资助为期五天的沉浸式研讨会，将准备初级和高级 研究人员都希望利用ABCD数据来研究大脑发育与以下方面的关系： 心理健康该研讨会将重点培训研究人员对可重复的神经成像 方法、预测建模方法和临床心理健康结果， 注重理论与应用。研讨会将由教学，辅导， 圆桌会议、分组会议和开放式黑客组件。研讨会与会者将 通过参加黑客挑战赛，立即应用他们在研讨会上学到的知识 开发基于脑成像数据的心理健康相关结果的分类工具， 同时注意相关的社会和环境因素。本次研讨会的主要成果 将是研究人员离开的答案，有关分析ABCD数据与新的 开发的工具，更深入地了解这些工具背后的理论，以及 高维数据的分析考虑。这将包括方法培训 关于临床结果和促进计算之间的合作的考虑 和临床研究人员的职业生涯。本次研讨会的另一个主要目的是 促进国家努力使训练有素的生物医学研究人员多样化， 通过消除与以下方面相关的参与障碍来招募多样化的与会者群体： 社会不平等，包括经济负担，养育子女或残疾，并通过创造一个安全和 工作坊期间的温馨氛围。本次研讨会的近期目标是 参加者获得以下能力：a）分析和统计知识 特定于大型开放数据集的考虑; B）如何进行可重复的研究， 强调神经成像; c）预测建模背后的理论知识和能力， 应用新开发的工具; d）设计和执行具有临床意义的研究 （e）确定影响发展的社会和环境因素; 精神病理学;和f）与来自不同背景的研究人员交流， 跨学科团队。拟议讲习班的传播目标包括出版 论文，在会议上发表，并开发任何代码或分析技术 在研讨会期间，可在更广泛的研究界的在线知识库中查阅。很长的- 本研讨会的长期目标是在研究人员之间形成可持续的跨学科网络 来自开发、临床和计算背景，因为这些专业领域都是 来增进我们对心理健康的理解

项目成果

Quadratic relations of BMI with depression and brain volume in children: Analysis of data from the ABCD study.

• DOI: 10.1016/j.jpsychires.2021.02.038
• 发表时间: 2021-04
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Bohon C;Welch H
• 通讯作者: Welch H

Brain network coupling associated with cognitive performance varies as a function of a child's environment in the ABCD study.

• DOI: 10.1038/s41467-021-27336-y
• 发表时间: 2021-12-10
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Ellwood-Lowe ME;Whitfield-Gabrieli S;Bunge SA
• 通讯作者: Bunge SA

Opportunities for increased reproducibility and replicability of developmental neuroimaging.

• DOI: 10.1016/j.dcn.2020.100902
• 发表时间: 2021-03
• 期刊: Developmental cognitive neuroscience
• 影响因子: 4.7
• 作者: Klapwijk ET;van den Bos W;Tamnes CK;Raschle NM;Mills KL
• 通讯作者: Mills KL