老年人囤积障碍：认知、病因和功能影响-猫眼课题宝

老年人囤积障碍：认知、病因和功能影响

批准号：

9751394

负责人：

Robert Scott Mackin

金额：

$61.05万

依托单位：

UNIVERSITY OF FLORIDA

依托单位国家：

美国

项目类别：

财政年份：

2018

资助国家：

美国

项目状态：

已结题

起止时间：

2018-07-26 至 2023-05-31

来源：

https://reporter.nih.gov/project-details/9751394

关键词：

Adolescence Adult Affect Age Aging Alzheimer&apos s Disease Attention deficit hyperactivity disorder Brain Health Registry Cessation of life Chronic Chronic Disease Clinical Clinical Trials Code Cognition Cognitive Comorbidity Complex Compulsive Hoarding Data Death Rate Development Diagnosis Disease Early identification Elderly Enrollment Epidemiology Etiology Family Family history of Fire - disasters Frequencies Frontotemporal Dementia Genetic Genetic Diseases Genetic Risk Genetic Variation Health Heritability Home environment Individual Intervention Interview Lead Learning Life Expectancy Longevity Medical Mental Depression Mental disorders Neurocognitive Deficit Neurodegenerative Disorders Neurodevelopmental Disorder Neurologic Neuropsychology Obesity Obsessive-Compulsive Disorder Parkinson Disease Participant Patient Self-Report Persons Phenotype Psychiatric Diagnosis Public Health Quality of life Reporting Research Research Personnel Resources Risk Role Safety Sampling Self Care Severities Societies Symptoms Time Variant Vulnerable Populations Work aged cognitive function cognitive process design disability disability impact early onset effective therapy fall risk frailty functional disability functional status genetic architecture improved information processing interest memory process nervous system disorder neuroimaging neuropsychiatry patient population visual learning visual memory

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英文摘要

Hoarding Disorder (HD) is a common, chronic and debilitating psychiatric disorder that disproportionately affects older adults, and has a profound public health impact on individuals, families and society. While safety risks associated with clutter in HD has been consistently documented (i.e. up to 25% of deaths by house fire are due to hoarding), the true extent of disability in this patient population is not known. Further, factors contributing to disability in older adults with HD, including cognitive factors, have not been adequately clarified. Emerging data, including work from our group, suggest that deficits in specific cognitive domains are common across the lifespan in HD. This project will examine the functional impact of HD in older adults – specifically, the relationships among cognitive functioning, hoarding symptom severity, and disability. Further, we will assess the genetic risk profile of HD, and the association of HD with medical and psychiatric comorbidities that also impact disability. To achieve our aims, we will combine in-person clinical, neuropsychological, and medical frailty assessments with a unique epidemiologic resource, the online Brain Health Registry (BHR; www.brainhealthregistry.org). The BHR, which was designed to accelerate participation in clinical trials of aging and aging- related disorders, has, in three years, enrolled over 54,000 subjects who are expressly interested in participating in ongoing research with 1000 new participants enrolling every month. Nearly half (47%) of participants are ages 60 and older. Participants are well characterized in regard to psychiatric, neurological, family and medical history, and are followed longitudinally with re-assessments every six months. Identifying factors related to disability in older adults with HD will inform the development of more effective treatment interventions in this vulnerable population and offers significant promise for improving quality of life.

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