Rural Comorbidity and HIV consequences of Opioid use Research and Treatment Initiative (Rural cohort)

农村阿片类药物使用研究和治疗行动的目的和艾滋病毒后果 (农村队列)协调中心(CC)将协调和支持由NIH资助的队列协作 进行评估并实施循证做法的研究，以解决阿片类药物的使用、艾滋病毒和 在他们的农村社区中相关的共病。最主要的目的是改善整体健康和 这一弱势群体的后果。还有机会增加艾滋病毒预防和预防的使用。 护理服务和解决阿片类药物的使用问题，有可能减少艾滋病毒发病率和预防新的艾滋病毒感染 药物使用者中的流行病。要实现这些目标，需要在数据方面有经验的CC 协调、多地点协调和研究物质使用干预措施及其影响 使用HIV携带者和非HIV携带者的物质全面整合来自 多项研究。由此产生的来自多项研究的全面整合的临床数据的大量来源 将使研究人员有可能解决与以下相关的重要科学和公共卫生问题 注射吸毒者的药物使用和艾滋病毒预防及结果(PWID)不会 在较小规模的研究中是可能的。作为农村群体CC，我们将与现场合作，允许复杂、谨慎和 使用统一的数据对许多不同人群的结果和结果进行完整的分析 网站。这将提高统计能力，以确定研究重点的领域或分组，并 了解哪些干预措施在整个农村人口的更广泛背景下被证明是成功的 PWID(相对于单一成员站点的目标人群)。将仔细协调数据 配合直观的交付工具，确保这些高质量的数据可广泛提供给会员 网站。农村队列CC团队在数据链接和协调、方法方面具有丰富的经验 开发、对观测研究的统计支持、平台和工具开发，如 高效、准确地收集患者报告的结果和结果裁决，提供总体 协调群组和研究的大型合作，并在临床流行病学方面有很强的背景 关于艾滋病毒和药物使用的信息。这将使我们能够协助研究改进和加强数据收集 在适当的情况下，在可行的情况下合并和协调数据，并更密切地合作，以解决 关于药物使用、艾滋病毒和农村环境中个人无法解决的结果的关键问题 学习。

The purpose of the Rural Comorbidity and HIV consequences of Opioid use Research and Treatment Initiative (Rural Cohort) Coordinating Center (CC) is to coordinate and support a cohort collaboration of NIH funded studies as they conduct assessments and implement evidence-based practices to address opioid use, HIV and related comorbidities in their rural communities. The overarching purpose is to improve the overall health and outcomes of this vulnerable population. There is also an opportunity to increase the use of HIV prevention and care services and address opioid use in ways that are likely to reduce HIV incidence and prevent new HIV epidemics among substance users. Achieving these objectives will require a CC experienced in data harmonization, multi-site coordination, and research on substance use interventions and impact among substance using populations with and without HIV to comprehensively integrate clinical research data from multiple studies. The resulting large resource of comprehensively integrated clinical data from multiple studies will give researchers the potential to address important scientific and public health questions related to substance use and HIV prevention and outcomes among persons who inject drugs (PWID) that would not be possible with smaller studies. As the Rural Cohort CC, we will work with sites to allow complex, careful, and complete analysis of outcomes and results over many diverse populations using harmonized data from across sites. This will improve the statistical power to identify areas or sub-groups for research focus and to understand what interventions are proving successful in the broader context of the whole population of rural PWID (as opposed to in the target population of a single member site). Careful data harmonization will be paired with intuitive delivery tools to ensure that this high-quality data is made widely available to the member sites. The Rural Cohort CC team brings vast experience with data linkage and harmonization, methods development, statistical support for observational research, platform and tool development such as for the efficient and accurate collection of patient reported outcomes and outcomes adjudication, providing overall coordination for large collaborations of cohorts and studies, and a strong background in clinical epidemiology of HIV and substance use. This will allow us to assist the studies to improve and enhance data collection where appropriate, merge and harmonize data when feasible, and work together more closely to address the key questions on substance use, HIV, and outcomes in rural settings that cannot be addressed by individual studies.