Effects of Aging and the Urinary Microbiome on Recurrent Urinary Tract Infections

衰老和泌尿微生物组对复发性尿路感染的影响

• 批准号: 9753089
• 负责人: NAZEMA Y SIDDIQUI
• 金额: $ 12.08万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753089
• 关键词: 16S ribosomal RNA sequencing; Adherence; Affect; Age; Age-Years; Aging; Antibiotics; Bacteria; Base Sequence; Bioinformatics; Bladder; Cessation of life; Data; Development; Diagnosis; Disease; Elderly; Environment; Estrogen Therapy; Estrogens; Female; Genetic; Goals; Health; Heterogeneity; Hospitalization; Impaired health; Incidence; Infection; Knowledge; Lactobacillus; Life; Menopause; Microbe; Population; Postmenopause; Premenopause; Prevalence; Procedures; Prophylactic treatment; Public Health; Recovery; Recurrence; Reporting; Research; Sepsis; Statistical Models; Sterility; Subgroup; Techniques; Testing; Urinary Microbiome; Urinary tract infection; Urine; Vagina; Woman; age effect; antimicrobial; base; cost; dysbiosis; epidemiology study; experience; experimental study; health related quality of life; improved; men; microbial community; microbiome; microbiota; multidisciplinary; non-genetic; older women; prophylactic; resilience; urinary; urologic

PROJECT SUMMARY/ABSTRACT Urinary tract infections (UTIs) are one of the most commonly diagnosed infections in older adults. UTIs cost $1.6 billion annually, impair health-related quality of life, and can have serious sequellae such as hospitalization, sepsis, or death. At all ages, UTIs are more prevalent in women than men, with up to 50% of all women experiencing a UTI during their lifetime. The incidence of UTI rises in older women with over 10% of women older than 65 and almost 30% of women older than 85 reporting a UTI within the prior 12 months. Among women with UTIs, there exists a subgroup with recurrent UTIs, defined as 3 or more culture proven infections within 12 months, or >2 culture proven infections in a 6 month period. Recurrent UTI is not only more common in women, but especially more common in the post- menopausal life stage. In some women with recurrent UTIs, genetic factors facilitate bacterial adherence and repeated infection. However, recurrent UTI prevalence rises significantly in post- menopausal women, suggesting additional non-genetic mechanisms associated with aging. The urinary microbiome is one potential non-genetic factor that could influence recurrent UTIs with aging. We now have significant evidence that a urinary microbiome exists, and that dysbiosis may be associated with health versus disease. Our long-term goal is to improve our understanding of the microbes that occupy the urinary niche, how these microbes change with aging, and to determine whether particular microbial community types are associated with recurrent UTI. We aim to compare urinary lactobacilli in populations of women without recurrent UTIs to assess how lactobacilli change with aging and with the presence of vaginal estrogen therapy. Next, we aim to assess whether urinary lactobacilli or other microbes are associated with recurrent UTI in postmenopausal women who are using vaginal estrogen. Finally, we aim to determine whether there are distinct microbial community types that are associated with recurrent UTI in older women.

项目总结/摘要 尿路感染是老年人中最常见的感染之一， 成年人了UTI每年花费16亿美元，损害与健康相关的生活质量，并可能导致严重的 后遗症如住院、败血症或死亡。在所有年龄段，UTI在以下人群中更为普遍： 女性多于男性，高达50%的女性在一生中经历过UTI。的 UTI的发病率在老年女性中上升，超过10%的65岁以上的女性和近30%的 年龄超过85岁的女性在过去12个月内报告了UTI。 在患有UTI的女性中，存在一个复发性UTI的亚组，定义为3个或更多 12个月内培养证实感染，或6个月内培养证实感染>2次。 复发性UTI不仅在女性中更常见，而且在术后更常见。 更年期生活阶段在一些患有复发性UTI的女性中，遗传因素促进了细菌感染。 坚持和反复感染。然而，复发性UTI患病率在治疗后显著上升， 绝经期妇女，提示与衰老相关的其他非遗传机制。 尿微生物组是一个潜在的非遗传因素，可能影响复发性 尿路感染伴衰老。我们现在有重要的证据表明，尿液微生物组的存在， 生态失调可能与健康与疾病有关。我们的长期目标是提高我们的 了解占据尿液生态位的微生物，这些微生物如何随着 老化，并确定特定的微生物群落类型是否与 复发性尿路感染我们的目的是比较尿乳酸杆菌在人群中的妇女没有复发 UTI评估乳酸杆菌如何随着年龄的增长和阴道雌激素的存在而变化 疗法接下来，我们的目标是评估尿中乳酸杆菌或其他微生物是否与 使用阴道雌激素的绝经后妇女的复发性UTI。最后，我们的目标是 确定是否有不同的微生物群落类型， 老年女性的复发性UTI。