Therapy for Metastatic breast cancer based on micro RNA silencing

基于微小RNA沉默的转移性乳腺癌治疗

基本信息

  • 批准号:
    9753181
  • 负责人:
  • 金额:
    $ 56.89万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-08-01 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

Treatment options for patients with metastatic breast cancer are severely limited and ultimately rely on palliative care representing an unmet clinical need. Previous studies have demonstrated that microRNAs play a significant role in the formation of metastasis including those from breast cancer. Considering the paucity of options for patients with metastasis from breast cancer, in this proposal we focused on targeting miR-10b proven to be responsible for metastatic spread. While previous studies showed that miR-10b drives invasion and migration of cancer cells from primary tumors, our recent discovery demonstrated that in metastatic cells it is also responsible for cell viability and proliferation and that survival of metastatic cells crucially depends on the high level of miR-10b expression. This discovery formed a cornerstone of our therapeutic strategy aimed at specific eradication of metastatic tumor cells. This will be done using imaging-capable modular nanodrugs, which distribute to lung, liver, bone, or brain metastases. These nanodrugs consist of magnetic nanoparticles that carry locked-nucleic acid (LNA) oligonucleotides inhibiting microRNA-10b. Targeting moieties conjugated to the nanoparticles facilitate their accumulation at distant metastatic sites. Previously we have demonstrated the feasibility of the proposed approach. Delivery of the nanodrug to lymph nodes with already formed metastases resulted in arrest of metastatic progression by inhibiting tumor cell proliferation and causing apoptosis, which is a phenomenon that has not been described before. When treatment with the nanodrug was combined with a low-dose of conventional chemotherapy (doxorubicin), there was regression and permanent elimination of lymph node or lung metastases without relapse even after treatment was discontinued. Unlike conventional chemotherapies, this therapeutic protocol was not associated with animal morbidity/mortality. In the current application we propose to use the miR10b-inhibitory nanodrug in combination with low-dose chemotherapy (where necessary) for targeting breast cancer metastases in distant organs. Noninvasive imaging will be used to evaluate the delivery of the nanodrug. If successful, this approach could be a life- extending (and possibly, life saving) alternative for patients with advanced metastatic disease for whom salvage therapy is the only current option.
转移性乳腺癌患者的治疗选择严重受限,最终依赖于

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ANNA MOORE其他文献

ANNA MOORE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ANNA MOORE', 18)}}的其他基金

Novel Prostate cancer therapy based on m-aconitase inhibition
基于 m-乌头酸酶抑制的新型前列腺癌疗法
  • 批准号:
    10435673
  • 财政年份:
    2022
  • 资助金额:
    $ 56.89万
  • 项目类别:
Novel Prostate cancer therapy based on m-aconitase inhibition
基于 m-乌头酸酶抑制的新型前列腺癌疗法
  • 批准号:
    10580844
  • 财政年份:
    2022
  • 资助金额:
    $ 56.89万
  • 项目类别:
Large Animal Facility for Imaging and Image-guided Therapies at MSU
密歇根州立大学用于成像和图像引导治疗的大型动物设施
  • 批准号:
    10373769
  • 财政年份:
    2021
  • 资助金额:
    $ 56.89万
  • 项目类别:
Therapy for Metastatic breast cancer based on micro RNA silencing
基于微小RNA沉默的转移性乳腺癌治疗
  • 批准号:
    10434241
  • 财政年份:
    2021
  • 资助金额:
    $ 56.89万
  • 项目类别:
anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals
用于治疗乳腺癌转移的抗 miR-10b 纳米药物:伴侣动物研究
  • 批准号:
    10659027
  • 财政年份:
    2021
  • 资助金额:
    $ 56.89万
  • 项目类别:
Therapy for Metastatic breast cancer based on micro RNA silencing
基于微小RNA沉默的转移性乳腺癌治疗
  • 批准号:
    10489811
  • 财政年份:
    2021
  • 资助金额:
    $ 56.89万
  • 项目类别:
anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals
用于治疗乳腺癌转移的抗 miR-10b 纳米药物:伴侣动物研究
  • 批准号:
    10450168
  • 财政年份:
    2021
  • 资助金额:
    $ 56.89万
  • 项目类别:
anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals
用于治疗乳腺癌转移的抗 miR-10b 纳米药物:伴侣动物研究
  • 批准号:
    10265643
  • 财政年份:
    2021
  • 资助金额:
    $ 56.89万
  • 项目类别:
Therapy for Metastatic breast cancer based on micro RNA silencing
基于微小RNA沉默的转移性乳腺癌治疗
  • 批准号:
    9979793
  • 财政年份:
    2018
  • 资助金额:
    $ 56.89万
  • 项目类别:
siRNA Protection of Composite Islet Kidney Transplant in Baboons
狒狒复合胰岛肾移植的 siRNA 保护
  • 批准号:
    8970851
  • 财政年份:
    2015
  • 资助金额:
    $ 56.89万
  • 项目类别:

相似海外基金

Linking Epidermis and Mesophyll Signalling. Anatomy and Impact in Photosynthesis.
连接表皮和叶肉信号传导。
  • 批准号:
    EP/Z000882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 56.89万
  • 项目类别:
    Fellowship
Digging Deeper with AI: Canada-UK-US Partnership for Next-generation Plant Root Anatomy Segmentation
利用人工智能进行更深入的挖掘:加拿大、英国、美国合作开发下一代植物根部解剖分割
  • 批准号:
    BB/Y513908/1
  • 财政年份:
    2024
  • 资助金额:
    $ 56.89万
  • 项目类别:
    Research Grant
Simultaneous development of direct-view and video laryngoscopes based on the anatomy and physiology of the newborn
根据新生儿解剖生理同步开发直视喉镜和视频喉镜
  • 批准号:
    23K11917
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
OSA 极端表型的遗传学及相关上呼吸道解剖学
  • 批准号:
    10555809
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
computational models and analysis of the retinal anatomy and potentially physiology
视网膜解剖学和潜在生理学的计算模型和分析
  • 批准号:
    2825967
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
    Studentship
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
  • 批准号:
    BB/X013227/1
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research: Social and ecological influences on brain anatomy
博士论文研究:社会和生态对大脑解剖学的影响
  • 批准号:
    2235348
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
    Standard Grant
Development of a novel visualization, labeling, communication and tracking engine for human anatomy.
开发一种新颖的人体解剖学可视化、标签、通信和跟踪引擎。
  • 批准号:
    10761060
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
Understanding the functional anatomy of nociceptive spinal output neurons
了解伤害性脊髓输出神经元的功能解剖结构
  • 批准号:
    10751126
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
Anatomy and functions of LTP interactomes and their relationship to small RNA signals in systemic acquired resistance
LTP相互作用组的解剖和功能及其与系统获得性耐药中小RNA信号的关系
  • 批准号:
    BB/X013049/1
  • 财政年份:
    2023
  • 资助金额:
    $ 56.89万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了