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Large Animal Facility for Imaging and Image-guided Therapies at MSU

密歇根州立大学用于成像和图像引导治疗的大型动物设施

基本信息

批准号：
10373769
负责人：
ANNA MOORE
金额：
$ 672.12万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-20 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10373769
关键词：
Animal Disease Models Animal Experimentation Animal Model Animals Area Biomedical Research Canis familiaris Cardiovascular Diseases Client Clinical Clinical Research Clinical Trials Collaborations Communities Comparative Study Data Development Diabetes Mellitus Diagnosis Diagnostic Disease Early Diagnosis Equipment Family suidae Funding Health Healthcare Healthcare Systems Human Human Biology Human Pathology Image Institution Laboratory Animals Length Link Longevity Magnetic Resonance Imaging Malignant Neoplasms Medicine Michigan Molecular Molecular Target New Agents Outcome Pathology Physiology Play Positron-Emission Tomography Precision Health Pregnancy Research Research Personnel Rodent Role Sheep Small Animal Imaging Systems Testing Therapeutic Agents Training Translating Translational Research Universities animal facility animal imaging bioimaging clinical imaging clinical practice clinically relevant college companion animal comparative human disease human model human subject image guided image guided therapy imaging facilities imaging system in vivo imaging mortality multidisciplinary novel therapeutics pre-clinical pre-clinical research precision medicine programs success translational study undergraduate student

项目摘要

ABSTRACT Precision health is an emerging paradigm in healthcare that focuses on early detection and molecular determinants of disease. Michigan State University (MSU) has launched a University-wide initiative to bring the principles of precision health into its healthcare systems. The success of this initiative depends, in large part, on our ability to obtain relevant data from predictive pre-clinical animal models and effective translational research. Advances in molecularly targeted diagnostic and therapeutic agents, the cornerstones of precision medicine, require reliable testing in informative animal models of human biology. Small laboratory animals (rodents) commonly used in biomedical research are often not suitable for studying pathologies where physiology, human markers, physical size, gestation length, lifespan, and other human-like features are key contributors to disease. Use of larger animal species for research, including dogs, pigs and sheep, can overcome many of these hurdles. It is widely accepted that in vivo imaging plays a pivotal role in nearly all areas of biomedical research and clinical practice, and the importance of its role will only increase with the development of new agents and therapies. However, imaging data obtained in small animal imaging systems cannot always be directly translated to studies in humans. Clearly, studying large animal models using clinical scanners would produce data that are closest to what we expect in humans, and would better inform translational studies. Further, the ability to study comparative diseases that occur spontaneously in domesticated species, as part of clinical studies of client- owned animals, will add further to translational relevance and data outcomes. For these reasons and to advance the clinical relevance of animal models, we are requesting funds to develop a multi-species large animal imaging facility at MSU. This facility will be equipped with a state-of-the-art high-end clinical imaging system (PET/MRI, mMR Biograph, Siemens) that would serve MSU’s diverse biomedical scientific and clinical communities. Researchers will use this facility for studies of large research animals, and client-owned companion animals to develop imaging and image-guided therapy approaches with focus on human pathologies linked to significant mortality rates (e.g., cardiovascular disease, cancer, and diabetes). This multidisciplinary facility will also support ongoing clinical trials in human subjects and serve as a training ground for undergraduate, graduate and postdoctoral trainees from 6 colleges, 12 departments and 7 programs. performing research on a full spectrum of human and animal disease models. This new biomedical imaging facility, in combination with human and veterinary expertise at MSU, creates an extraordinary opportunity to perform pre-clinical, clinical and translational research using clinical imaging equipment. These capabilities will promote high-level collaborations between MSU and investigators at regional and national institutions to ultimately champion and advance a premiere program in precision health and comparative medicine, benefiting both human and animal health in the diagnosis and treatment of disease.

摘要