Transport Oncophysics Core
运输肿瘤物理学核心
基本信息
- 批准号:9752962
- 负责人:
- 金额:$ 38.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AdjuvantAdverse effectsAffectBiodistributionBiologicalBiological TransportBiophysicsCellsClinicalCommunitiesComputer SimulationDataData AggregationData AnalysesData SetDevelopmentDimensionsDiseaseDrug KineticsDrug TransportEducation and OutreachEducational ModelsFundingGoalsHeterogeneityImageImage AnalysisImmuneImmune responseImmunotherapeutic agentImmunotherapyIndividualKineticsKnowledgeLawsLinkLogicMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of pancreasMammary NeoplasmsModalityModelingPatient-Focused OutcomesPatientsPenetrationPerformancePharmaceutical PreparationsPhysicsPositron-Emission TomographyProcessPropertyRationalizationRegimenResearchResearch PersonnelResearch Project GrantsResistanceRoleSeriesServicesTherapeuticTherapeutic AgentsTimeTissuesTreatment EfficacyVaccinesbasebiophysical propertiescancer immunotherapycomputerized toolsdata integrationdata managementdata sharingdata warehousedesigneffective therapyexpirationimmunogenicityimprovedin vivoindividualized medicineinnovationintravital microscopymalignant breast neoplasmmelanomananonanovaccineneglectnovelnovel therapeuticsoncologyoutreach programpancreatic cancer modelpancreatic neoplasmpathology imagingphysical sciencespatiotemporalsynergismtheoriestherapy outcometherapy resistanttooltumortumor growthtumor microenvironment
项目摘要
TRANSPORT ONCOPHYSICS CORE – SUMMARY
Cancer immunotherapy has recently been demonstrated to be quite effective for the treatment of lung cancer
and melanoma, but for other indications including breast and pancreatic cancers, its application remains to be
determined, given the additional challenges posed by the latter cancers (low immunogenicity). We believe that
optimizing the transport and penetration of drugs and immune cells, systemically and in the tumor
microenvironment, would improve the immune response in these cancers. Thus, the impact of transport
phenomena (physical spatio-temporal parameters and aberrations of tumors) on immunotherapeutic efficacy
should be considered for the development of effective immunotherapies. The proposed Center for
Immunotherapeutic Transport Oncophysics (CITO) is focused on determining these transport phenomena
in breast and pancreatic tumor models, in order to improve the transport of immunotherapies through tissues
and, ultimately, to enable the rational design of optimal immunotherapeutic regimens for patients as part of
individualized therapy. To support the CITO and its 2 research projects [Project 1 for the transport of cancer
Nano-dendritic (DC) vaccines; Project 2 for the biophysical barriers in the tumor microenvironment], the
Transport Oncophysics Core (TOC) will provide imaging, analysis, quantification, and unique oncophysical
computational tools to rationalize the delivery of immunotherapies, based on the oncophysical modeling
framework Transport and Biodistribution Theory (TBT). The TBT moves boundaries from classical tools used
to study pharmacokinetic and efficacy relations, and instead creates novel precision immunotherapeutic tools
to rationally tailor individual treatments to patients. The overall hypothesis of the TOC is that the biophysical
properties of tissues (as biological barriers) are determinants that govern biodistribution of
immunotherapeutics, upstream of (but in synergy with) specific biological target recognition. The distribution
affects efficacy, adverse effects, and resistance phenomena, and, ultimately - patient outcomes. The TOC will
aggregate data from the two projects and then provide specific services to rationalize development of and to
improve the delivery of immunotherapeutics. The TOC will offer three major services to the projects: imaging
(PET, IVM), data analysis and quantification, and application of computational biodistribution and tumor growth
models. The underlying logic is that in vivo and pathology imaging provides snapshots and time-lapses of the
biodistribution of therapeutics. The quantification of individual time-points and transport dynamics will create
time series of data for computational models to develop spatio-temporal biodistribution, which is a function of
the tumor microenvironment, immunotherapeutic modality, and their transport properties at therapeutically
relevant time-scales. Biodistribution of immunotherapy agents and the effects of adjuvants controlling transport
of immunotherapies will be correlated to therapeutic outcomes and tumor growth.
传输物理核心-摘要
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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Haifa Shen其他文献
Haifa Shen的其他文献
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{{ truncateString('Haifa Shen', 18)}}的其他基金
Mechanism of Intratumoral Transport of Particulate Drugs
颗粒药物的瘤内转运机制
- 批准号:
10053718 - 财政年份:2018
- 资助金额:
$ 38.95万 - 项目类别:
Mechanism of Intratumoral Transport of Particulate Drugs
颗粒药物的瘤内转运机制
- 批准号:
9723053 - 财政年份:2018
- 资助金额:
$ 38.95万 - 项目类别:
Tumor vasculature-targeted nanotherapeutics for DNA damage response
针对 DNA 损伤反应的肿瘤血管靶向纳米疗法
- 批准号:
9030253 - 财政年份:2015
- 资助金额:
$ 38.95万 - 项目类别:
Tumor vasculature-targeted nanotherapeutics for DNA damage response
针对 DNA 损伤反应的肿瘤血管靶向纳米疗法
- 批准号:
9188095 - 财政年份:2015
- 资助金额:
$ 38.95万 - 项目类别:
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