Genome Maintenance via the BRCA-PALB2 Tumor Suppressor Network
通过 BRCA-PALB2 肿瘤抑制网络进行基因组维护
基本信息
- 批准号:9752265
- 负责人:
- 金额:$ 36.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-01 至 2020-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectBARD1 geneBRCA1 geneBRCA2 geneBiochemicalBiochemical GeneticsBiologicalBiophysicsBreastC-terminalCancer BiologyCellsChemical AgentsChemicalsChromosomesCommunitiesComplexConflict (Psychology)DNADNA BindingDNA Binding DomainDNA Double Strand BreakDNA RepairDNA lesionDNA replication forkDefectDevelopmentEnsureExcisionFailureFanconi&aposs AnemiaFilamentFundingGenesGenetic TranscriptionGenomeGenome StabilityGenomic InstabilityHumanIn VitroIonizing radiationLeadLesionLigandsLightMaintenanceMalignant NeoplasmsMediatingMediator of activation proteinModelingMutationOvarianPancreasPathway interactionsPhasePrimary LesionProteinsRad51 recombinaseRadiobiologyReactionRegimenResearchResourcesRoleSingle-Stranded DNASyndromeTestingTimeTumor SuppressionTumor Suppressor Proteinsbasechemotherapycrosslinkgenome integrityhomologous recombinationin vivoinsightnovelnucleasepresynapticrecombinaserecombinational repairrepairedsingle moleculesuccesstargeted treatmenttool
项目摘要
PROJECT SUMMARY
Homologous recombination (HR) is a major chromosome damage repair tool. By eliminating DNA double-
strand breaks and other deleterious lesions, HR is indispensable for the maintenance of genome stability.
In humans, defects in HR directly lead to cancer. This renewal project focuses on the roles of the tumor
suppressors BRCA1, BARD1, BRCA2, and PALB2 in the HR-mediated repair of damaged chromosomes.
Considerable progress has been made during the last funding period, leading to important advances in
understanding HR mechanism. Capitalizing on our success, a variety of in vitro and in vivo studies will be
conducted to delineate the multifaceted roles of the BRCA1-BARD1-BRCA2-PALB2 ensemble in the HR
reaction that is catalyzed by the recombinase RAD51. Novel hypotheses regarding how the HR factors
facilitate the presynaptic stage of the HR reaction and how cancer mutations affect this critical HR step will
be tested. The results from this renewal project will continue to provide insights regarding the functions of
key HR factors, and will allow us to formulate detailed models of chromosome damage repair and genome
maintenance via the BRCA-PALB2 tumor suppressor network. Our studies have direct relevance to cancer
biology and to the development of chemical compounds to evaluate the potential of HR pathway-targeted
therapeutic strategies. Moreover, the research materials generated during the course of our studies
represent an invaluable resource for the DNA repair and cancer biology research communities.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Patrick Sung其他文献
Patrick Sung的其他文献
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{{ truncateString('Patrick Sung', 18)}}的其他基金
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
DNA同源引导的基因组修复和肿瘤抑制机制
- 批准号:
10013190 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
DNA同源引导的基因组修复和肿瘤抑制机制
- 批准号:
10250433 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
DNA同源引导的基因组修复和肿瘤抑制机制
- 批准号:
9812546 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
DNA同源引导的基因组修复和肿瘤抑制机制
- 批准号:
10475698 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
DNA Repair Genes and Proteins of the RAD52 Group
RAD52 组的 DNA 修复基因和蛋白质
- 批准号:
9879032 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
DNA同源引导的基因组修复和肿瘤抑制机制
- 批准号:
10598707 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
DNA同源引导的基因组修复和肿瘤抑制机制
- 批准号:
10663292 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
DNA同源引导的基因组修复和肿瘤抑制机制
- 批准号:
10690829 - 财政年份:2019
- 资助金额:
$ 36.96万 - 项目类别:
Roles of the nucleic acid motor protein ZGRF1 in chromosome damage repair
核酸马达蛋白ZGRF1在染色体损伤修复中的作用
- 批准号:
9753247 - 财政年份:2018
- 资助金额:
$ 36.96万 - 项目类别:
Roles of the nucleic acid motor protein ZGRF1 in chromosome damage repair
核酸马达蛋白ZGRF1在染色体损伤修复中的作用
- 批准号:
9575041 - 财政年份:2018
- 资助金额:
$ 36.96万 - 项目类别:














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