R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.
R01 应用:体重控制中的胆碱能信号传导的基因剖析。
基本信息
- 批准号:9754134
- 负责人:
- 金额:$ 35.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-15 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:AblationAcetylcholineAffectAnimal BehaviorBehaviorBehavioralBody WeightBrainBrain regionCardiovascular DiseasesCause of DeathCellsComplexDataDesire for foodDevelopmentDiabetes MellitusDiagonal Band of BrocaEatingElectrophysiology (science)Energy MetabolismExhibitsFeeding behaviorsGeneticGoalsHomeostasisHumanHyperphagiaHypothalamic structureIndividualKnowledgeMapsMediatingMetabolicMetabolismMorbid ObesityMutagenesisNeural PathwaysNeuraxisNeuronsNeurotransmittersObesityObesity associated diseasePathway interactionsPatternPharmaceutical PreparationsPhysiologicalPhysiologyPlayPopulationProcessProsencephalonRegulationResearchRodentRoleSatiationSignal PathwaySignal TransductionSmokingSynapsesTestingTreatment EfficacyUnited StatesWeight GainWeight maintenance regimenbasal forebraincellular targetingcholinergiccholinergic neuronexperimental studyfeedinggamma-Aminobutyric Acidhindbraininsightmolecular markerneural circuitneuroregulationnovelnutrient metabolismobesity developmentoptogeneticspostsynapticprogramsrelating to nervous systemside effectsmoking cessationtherapeutic development
项目摘要
Abstract/Project Summary
Obesity-associated diseases such as diabetes and cardiovascular disease together account for the leading
cause of death in the United States. Roughly one-third of the U.S. population is obese, and it is estimated that
nearly half of the population will be obese within the next two decades. To date, studies investigating the
neural contribution to body weight control have focused largely on neuropeptidergic signaling in the
hypothalamus, a key brain region involved in feeding behavior. However, signaling from extra-hypothalamic
brain regions has also been implicated in regulating nutrient metabolism, appetite, and satiety. We recently
uncovered a novel mechanism by which cholinergic signaling in the basal forebrain strongly influences body
weight control. This discovery provides intriguing evidence that specific cholinergic signaling pathways in the
brain critically regulate feeding behavior and body weight homeostasis. To elucidate the mechanisms by which
forebrain cholinergic signaling influences body weight management, feeding behaviors, and metabolism, we
will test the hypothesis that cholinergic signaling modulates metabolic and appetitive programs to regulate
body weight. Using a combination conditional genetic targeting, optogenetic manipulations, electrophysiology,
and behavioral analysis, we will set out to determine the role for basal forebrain cholinergic signaling in body
weight control and obesity.
摘要/项目摘要
与肥胖相关的疾病,如糖尿病和心血管疾病,
美国的死因。大约有三分之一的美国人口肥胖,据估计,
近一半的人口将在未来二十年内肥胖。迄今为止,研究
神经对体重控制的贡献主要集中在神经肽能信号传导上,
下丘脑,一个与进食行为有关的关键大脑区域。然而,来自下丘脑外的信号
大脑区域也与调节营养代谢、食欲和饱腹感有关。我们最近
揭示了一种新的机制,通过这种机制,基底前脑中的胆碱能信号强烈影响身体
体重控制这一发现提供了有趣的证据,表明特定的胆碱能信号通路,
大脑严格地调节进食行为和体重动态平衡。为了阐明
前脑胆碱能信号影响体重管理、摄食行为和代谢,我们
将测试胆碱能信号调节代谢和食欲程序的假设,
体重使用条件遗传靶向、光遗传学操作、电生理学,
和行为分析,我们将着手确定基底前脑胆碱能信号在体内的作用,
体重控制和肥胖。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Benjamin R Arenkiel其他文献
Benjamin R Arenkiel的其他文献
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{{ truncateString('Benjamin R Arenkiel', 18)}}的其他基金
Molecular specification of dopaminergic neuron diversity
多巴胺能神经元多样性的分子规范
- 批准号:
10585657 - 财政年份:2023
- 资助金额:
$ 35.4万 - 项目类别:
Neuronal anatomy, connectivity, and phenotypic innervation of the knee joint
膝关节的神经元解剖学、连接性和表型神经支配
- 批准号:
10608851 - 财政年份:2022
- 资助金额:
$ 35.4万 - 项目类别:
Mapping and Manipulating Cholingeric Basal Forebrain Activity in a Mouse Model of Alzheimer's Disease
阿尔茨海默病小鼠模型胆碱基前脑活动的绘制和操作
- 批准号:
10285121 - 财政年份:2021
- 资助金额:
$ 35.4万 - 项目类别:
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.
R01 应用:体重控制中的胆碱能信号传导的基因剖析。
- 批准号:
9152383 - 财政年份:2016
- 资助金额:
$ 35.4万 - 项目类别:
Genetically Dissecting Chorinergic Signaling in Body Weight Control
从基因角度剖析体重控制中的胆碱能信号
- 批准号:
10443883 - 财政年份:2016
- 资助金额:
$ 35.4万 - 项目类别:
Genetically Dissecting Chorinergic Signaling in Body Weight Control
从基因角度剖析体重控制中的胆碱能信号
- 批准号:
10259773 - 财政年份:2016
- 资助金额:
$ 35.4万 - 项目类别:
Genetically Dissecting Chorinergic Signaling in Body Weight Control
从基因角度剖析体重控制中的胆碱能信号
- 批准号:
10647885 - 财政年份:2016
- 资助金额:
$ 35.4万 - 项目类别:
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