Research and Mentoring in Comparative Effectiveness and Implementation Science

 描述(由申请人提供)：Peter K.Lindenauer医学硕士是一名住院医生，塔夫茨大学医学院和塔夫茨临床与翻译科学研究所副教授，贝斯托医学中心护理质量研究中心主任。在过去的7年里，他建立了一个国家认可的、独立的、由美国国立卫生研究院资助的比较有效性研究和实施科学项目，专注于慢性阻塞性肺疾病(COPD)患者的医院管理。在同一时期，他培养了许多住院医生、研究员和初级教员的学术生涯，他们取得了学术晋升，并在以患者为导向的研究中发展了独立的研究生涯。他是目前5名K获奖者的主要导师，涵盖NHLBI、NICHD、AHRQ和Tuft/NCATS，并是其他11名研究人员的共同导师。他的长期目标是进行以患者为中心的研究，以改善肺部疾病患者的护理质量和结果，特别是在住院期间和之后，并为对以患者为中心的研究感兴趣的新研究人员提供指导。这项建议的目的是：1)通过正式的课程和资深导师的监督，继续培养他的指导技能，利用他作为护理质量研究中心主任和CTSI导师核心小组成员的角色，选择有前途的候选人进行培训，并确保当前的学员成功过渡到K和R奖项；2)继续建立一个围绕改善对COPD恶化住院患者的护理的研究计划。这一目标将通过他目前资助的研究来实现，其中包括题为“非侵入性呼吸机在COPD中的实施和结果”的NLHBIR18，以及通过该奖项提出的新研究，该研究将使用定性和定量相结合的方法来检查COPD住院后早期肺康复的使用和有效性。这些项目将为学员提供必要的研究基础设施和机会，以便在这一框架下发展他们自己的项目。拟议的指导计划从普通内科医学、肺和重症护理医学、心脏病学和急诊医学等领域挑选有前途的候选人，并在林德诺博士的指导下提供系统和严格的研究培训和职业发展计划。该计划与塔夫茨CTSI和萨克勒学院的临床和转化科学研究生计划完全整合。在贝州医学中心和塔夫茨CTSI的大力支持下，这一奖项将确保Lindenauer博士能够继续投入所需的大量时间，为下一代以患者为导向的研究人员提供高质量的指导，同时继续培养他在肺部疾病方面的指导技能和研究计划。

 DESCRIPTION (provided by applicant): Peter K. Lindenauer MD MSc is a hospitalist, Associate Professor of Medicine at the Tufts University School of Medicine and Tufts Clinical and Translational Science Institute, and Director of the Center for Quality of Care Research at Baystate Medical Center. Over the past 7 years he has built a nationally recognized, independent, NIH-funded program in comparative effectiveness research and implementation science focused on the hospital management of patients with Chronic Obstructive Pulmonary Disease (COPD). During this same period he has fostered the academic careers of numerous residents, fellows, and junior faculty who have achieved academic promotion and have developed independent research careers in patient-oriented research. He is the primary mentor to 5 current K awardees, spanning NHLBI, NICHD, AHRQ and Tufts/NCATS, and is a co-mentor to 11 other investigators. His long-term goals are to conduct patient-oriented research to improve the quality of care and outcomes for patients with lung disease, especially during and following hospitalization, and to provide mentoring to new investigators with an interest in patient-oriented research. The aims of this proposal are 1) To continue to build his mentoring skills through formal coursework and supervision by senior mentors, leveraging his role as Director of the Center for Quality of Care Research and member of the core group of CTSI mentors to select promising candidates for training, and to ensure that current mentees successfully transition to K and R awards; 2) To continue to build a research program around improving care for patients hospitalized with exacerbations of COPD. This aim will be accomplished through his currently funded studies, including an NLHBI R18 entitled "Implementation and Outcomes of Noninvasive Ventilation in COPD", and by new research proposed through this award that will use mixed qualitative and quantitative methods to examine the use and effectiveness of Pulmonary Rehabilitation in the early period following hospitalization for COPD. These projects will provide the necessary research infrastructure and opportunities for mentees to develop their own projects under this umbrella. The mentoring program that is proposed selects promising candidates from the fields of general internal medicine, pulmonary and critical care medicine, cardiology, and emergency medicine and provides a structured and rigorous program of research training and career development under Dr. Lindenauer's mentorship. The program is fully integrated with the Tufts CTSI and Sackler School graduate programs in Clinical and Translational Science. In the strongly supportive environment of Baystate Medical Center and the Tufts CTSI, this award will ensure that Dr. Lindenauer can continue to invest the substantial time required to provide high quality mentoring to the next generation of patient-oriented researchers while continuing to build his mentoring skills and research program in lung disease.