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Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD

姜黄素疗法治疗 ADPKD 儿童和年轻人的血管功能障碍

基本信息

批准号：
9754811
负责人：
Kristen Lynn Nowak
金额：
$ 15.13万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9754811
关键词：
Acute Adult Affect Age Age-Years American Antioxidants Aorta Arteries Ascorbic Acid Autosomal Dominant Polycystic Kidney Biological Blood Vessels Cardiovascular Diseases Cardiovascular system Carotid Arteries Cause of Death Child Childhood Conduct Clinical Trials Curcumin Cyst Cystic Kidney Diseases Cystic kidney Data Development Disease Disease Progression Double-Blind Method Double-blind trial Effectiveness Endothelium Event Functional disorder Future Genetic Diseases Genetic Transcription Goals Growth Health Human Hypertension Impairment In Vitro Inflammation Infusion procedures Kidney Kidney Diseases Life MRI Scans Magnetic Resonance Imaging Mass Spectrum Analysis Measures Mediating Methods Nature Nutraceutical Oral Oxidative Stress Patients Physiologic pulse Physiological Placebos Population Prognostic Marker Randomized Randomized Clinical Trials Renal function Research Rodent Model Spices Testing Therapeutic Tumeric Urine Vascular Diseases aged arterial stiffness brachial artery cardiovascular disorder prevention endothelial dysfunction improved in vivo insight kidney cell mortality novel patient subsets polyphenol prevent public health relevance vascular endothelial dysfunction young adult

项目摘要

DESCRIPTION (provided by applicant): Although often considered to be a disease of adults, complications of ADPKD begin in childhood. While the hallmark of ADPKD is the development and continued growth of multiple renal cysts that result in ultimate loss of kidney function, the leading cause of death among affected patients is cardiovascular in nature. Vascular dysfunction (endothelial dysfunction and large elastic artery stiffness) is evident very early in te course of the disease and appears to involve increased oxidative stress and inflammation. Treatment options to prevent CVD in adults with ADPKD are limited, thus childhood may represent a key therapeutic window. Curcumin is a safe, naturally occurring polyphenol found in the Indian spice turmeric that has a unique ability to activate transcription of key antioxidants, suppress inflammation, and reduce proliferation. Aim 1 will assess the efficacy of curcumin (25 mg/kg/day) for improving vascular function in children and young adults (6-22 years of age) with ADPKD, using a 1 year randomized, placebo-controlled, double-blind trial. Aim 2 will determine (in a sub-group of patients 18-22 years of age), if improvements are associated with reduced oxidative stress and inflammation, utilizing state of the art mass spectrometry methods. A third exploratory aim will assess changes in total kidney volume using MRI scans. This study has the potential to establish a novel, safe, and easy to deliver therapy for the treatment of arterial dysfunction, and possibly renal cystic disease, in an understudied population of children and young adults with ADPKD.

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial .

DOI：
10.5414/cn109982
发表时间：
2020-07
期刊：
Clinical nephrology
影响因子：
1.1
作者：
Nowak KL;Chonchol M;Jovanovich A;You Z;Ambrosius WT;Cho ME;Glasser S;Lash J;Simmons DL;Taylor A;Weiner D;Rastogi A;Oparil S;Supiano MA
通讯作者：
Supiano MA

Vascular Dysfunction, Oxidative Stress, and Inflammation in Chronic Kidney Disease.

DOI：
10.34067/kid.0000962019
发表时间：
2020-06
期刊：
Kidney360
影响因子：
0
作者：
Nowak KL;Jovanovich A;Farmer-Bailey H;Bispham N;Struemph T;Malaczewski M;Wang W;Chonchol M
通讯作者：
Chonchol M

Does inflammation affect outcomes in dialysis patients?