Single-Frame X-ray Tomosynthesis

单帧 X 射线断层合成

• 批准号: 9756376
• 负责人: Scott Sigao Hsieh
• 金额: $ 18.84万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2019-11-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756376
• 关键词: Ablation; Architecture; Atherosclerosis; Calcium; Cardiac; Cardiovascular Diseases; Collimator; Conformal Radiotherapy; Coronary artery; Data; Data Set; Deposition; Detection; Development; Devices; Diagnostic radiologic examination; Disease; Dose; Esophagus; Exhibits; Family suidae; Feedback; Future; Grant; Heart Diseases; Human Volunteers; Image; Incidence; Location; Lung; Lung Neoplasms; Magnetic Resonance Imaging; Malignant neoplasm of lung; Measures; Medical History; Medical Imaging; Modality; Motion; Multi-Ethnic Study of Atherosclerosis; Patient risk; Patients; Pharmaceutical Preparations; Pilot Projects; Public Health; Radiation Dose Unit; Radiation Oncology; Radiation Pneumonitis; Radiation exposure; Radiation induced damage; Radiation therapy; Reader; Residual state; Resolution; Risk; Risk Marker; Risk stratification; Roentgen Rays; Route; Safety; Skin; Source; Speed; System; Technology; Time; Toxic effect; cardiovascular health; clinical application; coronary artery calcium; cost; design; design and construction; detector; health goals; heart motion; high risk; improved; innovation; lifestyle intervention; lung development; mortality; novel; personalized management; prototype; reconstruction; respiratory; screening; simulation; temporal measurement; tomosynthesis; tool; tumor

PROJECT SUMMARY We have developed a novel single-frame x-ray tomosynthesis (SFXT) imaging architecture that can image at 30 frames per second. Compared to conventional tomosynthesis, SFXT has a reduced field of view and projection count but 10 to 100 times higher temporal resolution. This dramatic increase in speed has the potential to open new clinical applications. The device utilizes standard components and is simple in design compared to CT or MRI. We will build a prototype system, image both stationary and moving phantoms, and conduct a pilot study to image swine during normal respiratory and cardiac motion. We will further evaluate the utilization of SFXT in two specific applications. First, in radiation oncology, SFXT could guide the treatment of lung stereotactic body radiation therapy (SBRT). By providing real-time feedback of the lung tumor location, SFXT could enable safer ablation of central lung tumors with reduced incidence of radiation pneumonitis or damage to the central airways, great vessels, or esophagus. Second, in the detection of cardiovascular disease, SFXT could visualize calcium deposits in the coronary arteries. This has previously been achieved using CT, but SFXT would provide the cost and radiation exposure profile necessary for calcium scoring to become a routine tool in the personalized management of cardiovascular health. Still other, undiscovered applications may be enabled by the high temporal resolution of SFXT.

项目摘要 我们开发了一种新的单帧X射线断层合成（SFXT）成像架构，可以在30 每秒帧数。与传统的断层合成摄影相比，SFXT具有更小的视野和投影 但时间分辨率要高10到100倍。这种速度的大幅提高有可能打开 新的临床应用。该设备使用标准组件，与CT或CT相比设计简单。 核磁共振我们将建立一个原型系统，对静止和运动的幻影进行成像，并进行初步研究 在正常的呼吸和心脏运动过程中对猪进行成像。我们将进一步评估SFXT的使用情况， 两个具体应用。首先，在放射肿瘤学中，SFXT可以指导肺立体定向体的治疗 放射治疗（SBRT）。通过提供肺部肿瘤位置的实时反馈，SFXT可以实现更安全的 消融中央肺肿瘤，降低放射性肺炎或中央气道损伤的发生率， 大血管或食道。第二，在心血管疾病的检测中，SFXT可以可视化钙 冠状动脉中的沉积物。这在以前是通过CT实现的，但SFXT将提供成本 以及钙评分所需的辐射暴露概况，以成为个性化治疗中的常规工具。 心血管健康管理。还有其他的，未被发现的应用程序可以通过高性能来启用。 SFXT的时间分辨率。