FASEB SRC on Ion Channel Regulation

项目总结 这是为第九届FASE B科学研究会议提供部分资助的申请 论离子通道调控。这次会议的目的是；激发话语，种子 新想法，并以加速有关ION的新发现的方式促进协作 在基础和翻译两级建立渠道，并为受训人员提供参与论坛 科学会议和职业发展活动。离子通道功能的调节是 对多种生理功能至关重要，包括神经元信号、疼痛转导和 心脏的跳动。占人类基因的~2%，离子通道受到 大量致病突变，导致超过55种遗传性疾病，称之为 影响大脑(例如，癫痫、偏头痛、共济失调、自闭症)、心脏(例如， 心律失常)和其他组织(例如，疼痛、听力和视力障碍，囊性纤维化， 高血压、肌肉疾病)。毫不奇怪，离子通道是药物的主要靶点。 治疗癫痫、神经性疼痛、高血压和心律失常。失调症 离子通道与精神疾病和癌症密切相关，这两种疾病都是深刻的 全球健康问题。因此，我们会议的议题既及时又高度相关，对 广大的科学家、临床医生和普通民众。2019年联席主席 会议将由亨利·科勒夫特博士(哥伦比亚大学)和拉杰什·坎纳博士(哥伦比亚大学)主持。 亚利桑那州)，两位都是离子通道生物学领域公认的领导者，重点是离子通道 监管。该方案包括九个科学会议、两个主旨演讲和两个 分组会议侧重于学术界/国立卫生研究院和工业/生物技术部门的职业生涯， 分别进行了分析。还将举办职业发展午餐会，个别餐桌将重点介绍 奖学金，其他资助，申请博士后和教师职位的策略，职业早期 战略等。大多数科学会议是围绕一般主题组织的，而不是离子 通道子类型，以促进场之间的串扰，通常在传统 会议。将有36名演讲者进行全面演讲，其中至少有16名女性(44% 发言者中有2人)和9名会议主席(其中4人为女性，占44%)。大多数受邀的演讲者 (75%)在前两次会议期间没有在本次会议上发表过演讲，45%的人从未在此会议上发表过演讲 自2003年会议开始以来一直在会议上介绍。在36位演讲者中，我们计划 包括6名职业生涯早期调查员和6名代表不足的少数族裔成员 科学(17%)，将在14个简短的演讲中得到支持的数字将从提交的报告中选出 摘要。

PROJECT SUMMARY This is an application for partial support of the 9th biennial FASEB Science Research Conference on Ion Channel Regulation. The objectives of this conference are to; stimulate discourse, seed new ideas, and facilitate collaboration in ways that will accelerate new discoveries about ion channels at the basic and translational levels, and to provide a forum for trainees to participate in scientific sessions and in career development activities. Regulation of ion channel function is essential for myriad physiological functions including neuronal signaling, pain transduction, and the beating of the heart. Accounting for ~2% of human genes, ion channels are subject to numerous disease-causing mutations, leading to over 55 inherited disorders termed “channelopathies” that affect the brain (e.g., epilepsy, migraine, ataxia, autism), the heart (e.g., cardiac arrhythmia), and other tissues (e.g., pain, hearing and vision impairment, cystic fibrosis, hypertension, muscle disease). Not surprisingly, ion channels are major drug targets in the treatment of epilepsy, neuropathic pain, hypertension and cardiac arrhythmia. Dysregulation of ion channels is strongly associated with mental illness and cancer, both of which are profound global health concerns. Thus, the topic of our conference is both timely and highly relevant for a broad population of scientists, clinicians, and the general public. The Co-chairs of the 2019 conference will be Drs. Henry Colecraft (Columbia University) and Rajesh Khanna (University of Arizona), both recognized leaders in ion channel biology with an emphasis on ion channel regulation. The Program consists of nine scientific sessions, two keynote addresses, and two breakout sessions focused on careers in academia/NIH and industry/biotechnology sectors, respectively. There will also be career development lunches with individual tables focusing on fellowships, other funding, strategies for applying for postdocs and faculty positions, early career strategies, etc. Most scientific sessions are organized around general themes rather than ion channel subtype, to foster crosstalk between fields typically kept separate in traditional conferences. There will be 36 session speakers giving full talks, including at least 16 women (44% of speakers) and 9 session chairs (4 of whom are women, 44%). Most of the invited speakers (75%) have not presented at this conference during the prior two meetings and 45% have never presented at the meeting since it started in 2003. Of the 36 session speakers, we are planning to include 6 early career stage investigators and 6 members of under-represented minorities in science (17%), numbers that will be bolstered in 14 short talks to be selected from submitted abstracts.