FASEB SRC on Ion Channel Regulation

项目摘要 这是第九届两年一度的FASEB科学研究会议的部分支持申请 离子通道调节本次会议的目标是：激发讨论， 新的想法，并促进合作的方式，将加快新的发现离子 在基础和翻译层面提供渠道，并为受训者提供一个论坛， 科学会议和职业发展活动。离子通道功能的调节是 对无数生理功能至关重要，包括神经元信号传导，疼痛传导， 心脏的跳动占人类基因的约2%，离子通道受 许多致病突变，导致超过55种遗传性疾病， 影响大脑的“通道病”（例如，癫痫、偏头痛、共济失调、自闭症），心脏（例如， 心律失常），和其它组织（例如，疼痛、听力和视力障碍、囊性纤维化， 高血压、肌肉疾病）。毫不奇怪，离子通道是药物的主要靶点， 治疗癫痫、神经性疼痛、高血压和心律失常。失调 离子通道与精神疾病和癌症密切相关，这两种疾病都是意义深远的 全球健康问题。因此，我们会议的主题对于一个 广大科学家、临床医生和公众。2019年联合主席 会议将由亨利科尔克拉夫特博士（哥伦比亚大学）和拉杰什卡纳（哥伦比亚大学）。 亚利桑那州），都公认的领导人在离子通道生物学的重点是离子通道 调控该计划包括九个科学会议，两个主题演讲， 分组会议侧重于学术界/NIH和工业/生物技术部门的职业生涯， 分别也将有职业发展午餐与个人表重点放在 奖学金，其他资金，申请博士后和教师职位的策略，早期职业生涯 大多数科学会议是围绕一般主题而不是离子组织的 通道子类型，以促进在传统的通信系统中通常保持分离的场之间的串扰。 两会将有36名会议发言人进行全面演讲，其中至少包括16名女性（44% 会议主席9名（其中4名为妇女，占44%）。大部分受邀演讲者 (75在前两次会议期间没有在本次会议上发言，45%从未在会议上发言。 自2003年开始以来一直在会议上提出。在36位演讲者中，我们计划 包括6名处于职业早期阶段调查员和6名代表性不足的少数民族成员， 科学（17%），将在14个简短的演讲中得到支持，这些演讲将从提交的 摘要。

PROJECT SUMMARY This is an application for partial support of the 9th biennial FASEB Science Research Conference on Ion Channel Regulation. The objectives of this conference are to; stimulate discourse, seed new ideas, and facilitate collaboration in ways that will accelerate new discoveries about ion channels at the basic and translational levels, and to provide a forum for trainees to participate in scientific sessions and in career development activities. Regulation of ion channel function is essential for myriad physiological functions including neuronal signaling, pain transduction, and the beating of the heart. Accounting for ~2% of human genes, ion channels are subject to numerous disease-causing mutations, leading to over 55 inherited disorders termed “channelopathies” that affect the brain (e.g., epilepsy, migraine, ataxia, autism), the heart (e.g., cardiac arrhythmia), and other tissues (e.g., pain, hearing and vision impairment, cystic fibrosis, hypertension, muscle disease). Not surprisingly, ion channels are major drug targets in the treatment of epilepsy, neuropathic pain, hypertension and cardiac arrhythmia. Dysregulation of ion channels is strongly associated with mental illness and cancer, both of which are profound global health concerns. Thus, the topic of our conference is both timely and highly relevant for a broad population of scientists, clinicians, and the general public. The Co-chairs of the 2019 conference will be Drs. Henry Colecraft (Columbia University) and Rajesh Khanna (University of Arizona), both recognized leaders in ion channel biology with an emphasis on ion channel regulation. The Program consists of nine scientific sessions, two keynote addresses, and two breakout sessions focused on careers in academia/NIH and industry/biotechnology sectors, respectively. There will also be career development lunches with individual tables focusing on fellowships, other funding, strategies for applying for postdocs and faculty positions, early career strategies, etc. Most scientific sessions are organized around general themes rather than ion channel subtype, to foster crosstalk between fields typically kept separate in traditional conferences. There will be 36 session speakers giving full talks, including at least 16 women (44% of speakers) and 9 session chairs (4 of whom are women, 44%). Most of the invited speakers (75%) have not presented at this conference during the prior two meetings and 45% have never presented at the meeting since it started in 2003. Of the 36 session speakers, we are planning to include 6 early career stage investigators and 6 members of under-represented minorities in science (17%), numbers that will be bolstered in 14 short talks to be selected from submitted abstracts.