FASEB SRC on Ion Channel Regulation

FASEB SRC 关于离子通道调节

• 批准号: 9756745
• 负责人: Henry M. Colecraft
• 金额: $ 3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2020-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756745
• 关键词: Academia; Accounting; Address; Affect; Area; Arizona; Arrhythmia; Asia; Ataxia; Award; Biology; Biotechnology; Brain; Canada; Caring; Cell physiology; Cells; Chemical Engineering; Collaborations; Cystic Fibrosis; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Drug Targeting; Educational workshop; Ensure; Epilepsy; Europe; Faculty; Family; Fellowship; Fertilization; Financial Support; Fostering; Functional disorder; Funding; Future; Gene Expression; General Population; Genes; Goals; Government; Grant; Heart; Hereditary Disease; Homeostasis; Hormone secretion; Human; Human Genome; Hypertension; Image; Individual; Industry; Inherited; Integral Membrane Protein; Ion Channel; Ions; Liquid substance; Malignant Neoplasms; Mass Spectrum Analysis; Mental disorders; Mentors; Mentorship; Migraine; Molecular; Mus; Muscle Contraction; Mutation; Myopathy; Neurons; Organelles; Pain; Parkinson Disease; Participant; Pathogenesis; Phenotype; Physiological; Physiological Processes; Physiology; Play; Population; Portugal; Positioning Attribute; Postdoctoral Fellow; Publishing; Rare Diseases; Regulation; Research; Research Personnel; Resources; Role; Science; Scientist; Seeds; Senior Scientist; Signal Transduction; Social Interaction; Stomach; Structure; Students; Synaptic Transmission; Therapeutic; Time; Tissues; Underrepresented Minority; United States National Institutes of Health; Universities; Visual impairment; Woman; autism spectrum disorder; career; career development; chronic pain; disease-causing mutation; drug development; global health; hearing impairment; human disease; lectures; meetings; member; neurotransmission; painful neuropathy; periodic paralysis; posters; prevent; programs; social; sudden cardiac death; symposium; synergism

PROJECT SUMMARY This is an application for partial support of the 9th biennial FASEB Science Research Conference on Ion Channel Regulation. The objectives of this conference are to; stimulate discourse, seed new ideas, and facilitate collaboration in ways that will accelerate new discoveries about ion channels at the basic and translational levels, and to provide a forum for trainees to participate in scientific sessions and in career development activities. Regulation of ion channel function is essential for myriad physiological functions including neuronal signaling, pain transduction, and the beating of the heart. Accounting for ~2% of human genes, ion channels are subject to numerous disease-causing mutations, leading to over 55 inherited disorders termed “channelopathies” that affect the brain (e.g., epilepsy, migraine, ataxia, autism), the heart (e.g., cardiac arrhythmia), and other tissues (e.g., pain, hearing and vision impairment, cystic fibrosis, hypertension, muscle disease). Not surprisingly, ion channels are major drug targets in the treatment of epilepsy, neuropathic pain, hypertension and cardiac arrhythmia. Dysregulation of ion channels is strongly associated with mental illness and cancer, both of which are profound global health concerns. Thus, the topic of our conference is both timely and highly relevant for a broad population of scientists, clinicians, and the general public. The Co-chairs of the 2019 conference will be Drs. Henry Colecraft (Columbia University) and Rajesh Khanna (University of Arizona), both recognized leaders in ion channel biology with an emphasis on ion channel regulation. The Program consists of nine scientific sessions, two keynote addresses, and two breakout sessions focused on careers in academia/NIH and industry/biotechnology sectors, respectively. There will also be career development lunches with individual tables focusing on fellowships, other funding, strategies for applying for postdocs and faculty positions, early career strategies, etc. Most scientific sessions are organized around general themes rather than ion channel subtype, to foster crosstalk between fields typically kept separate in traditional conferences. There will be 36 session speakers giving full talks, including at least 16 women (44% of speakers) and 9 session chairs (4 of whom are women, 44%). Most of the invited speakers (75%) have not presented at this conference during the prior two meetings and 45% have never presented at the meeting since it started in 2003. Of the 36 session speakers, we are planning to include 6 early career stage investigators and 6 members of under-represented minorities in science (17%), numbers that will be bolstered in 14 short talks to be selected from submitted abstracts.

项目概要 这是第九届两年一度的FASEB科学研究会议部分支持的申请 关于离子通道调节。本次会议的目标是：激发话语、种子 新想法，并以加速离子新发现的方式促进合作 基础层和翻译层的渠道，并为学员提供参与的论坛 科学会议和职业发展活动。离子通道功能的调节是 对于多种生理功能至关重要，包括神经元信号传导、疼痛传导和 心脏的跳动。离子通道约占人类基因的 2%，受 许多致病突变，导致超过 55 种遗传性疾病 “通道病” 影响大脑（例如癫痫、偏头痛、共济失调、自闭症）、心脏（例如 心律失常）和其他组织（例如疼痛、听力和视力障碍、囊性纤维化、 高血压、肌肉疾病）。毫不奇怪，离子通道是主要的药物靶点 治疗癫痫、神经性疼痛、高血压和心律失常。失调 离子通道与精神疾病和癌症密切相关，两者都具有深远的影响 全球健康问题。因此，我们这次会议的主题对于当今世界来说既及时又具有高度的现实意义。 广泛的科学家、临床医生和公众。 2019年联合主席 会议将由博士。 Henry Colecraft（哥伦比亚大学）和 Rajesh Khanna（哥伦比亚大学） 亚利桑那州），两者都是离子通道生物学领域公认的领导者，重点是离子通道 规定。该计划包括九场科学会议、两场主题演讲和两场 分组会议重点关注学术界/NIH 和工业/生物技术领域的职业， 分别。还将举办职业发展午餐会，每桌的重点是 奖学金、其他资助、申请博士后和教职职位的策略、早期职业生涯 策略等。大多数科学会议都是围绕一般主题而不是离子主题组织的。 通道子类型，以促进通常在传统中保持独立的字段之间的串扰 会议。将有 36 名会议发言人进行全面演讲，其中至少有 16 名女性（44%） 发言人）和 9 名会议主席（其中 4 名是女性，占 44%）。大部分受邀演讲者 (75%) 在前两次会议期间未曾出席本次会议，45% 从未出席过 自 2003 年召开以来一直在会议上提出。在 36 位会议发言者中，我们计划 包括 6 名早期职业阶段调查员和 6 名代表性不足的少数族裔成员 科学（17%），这些数字将在 14 场简短演讲中得到支持，这些演讲将从提交的内容中选出 摘要。

项目成果

The 2019 FASEB Science Research Conference on Ion Channel Regulation: Molecules to Disease, July 7-12, 2019, Lisbon, Portugal.

2019 年 FASEB 离子通道调控科学研究会议：分子与疾病，2019 年 7 月 7-12 日，葡萄牙里斯本。

• DOI: 10.1096/fj.202000367
• 发表时间: 2020
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Colecraft,HenryM;Khanna,Rajesh
• 通讯作者: Khanna,Rajesh