The Impact of Gestational and Postnatal Triclosan Exposure on Eczema, Wheeze, and Asthma Risk in Children

妊娠期和产后接触三氯生对儿童湿疹、喘息和哮喘风险的影响

• 批准号: 9756816
• 负责人: Medina Samira Jackson-Browne
• 金额: $ 1.87万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756816
• 关键词: 14 year old; Address; Affect; African American; Age; Allergic; Allergic Disease; Allergic rhinitis; Asthma; Atopic Dermatitis; Bacteria; Biological; Biological Markers; Birth; Centers for Disease Control and Prevention (U.S.); Chemical Exposure; Chemicals; Child; Child Health; Childhood; Childhood Asthma; Cohort Studies; Coupled; Data; Development; Disease; Drug Metabolic Detoxication; Eczema; Environment; Environmental Risk Factor; Epidemiologic Methods; Epidemiologist; Etiology; Exhalation; Exposure to; Extrinsic asthma; Fetus; Forced expiratory volume function; Foundations; Funding; Future; Goals; Growth and Development function; Health; Helper-Inducer T-Lymphocyte; High Prevalence; Hispanics; Hypersensitivity; Immune; Immune response; Immune system; Impairment; Incidence; Intervention; K-Series Research Career Programs; Knowledge; Learning; Life; Link; Measures; Medical; Mentorship; Modeling; Modification; Mothers; Neighborhoods; Nitric Oxide; Outcome; Outcome Measure; Pathway interactions; Pattern; Phenols; Phenotype; Physiology; Positioning Attribute; Predisposition; Pregnancy; Pregnant Women; Prevalence; Property; Pulmonary function tests; Questionnaires; Race; Research; Research Personnel; Research Training; Respiratory System; Respiratory physiology; Risk; Risk Factors; Role; Skin; Statistical Methods; Time; Training; Translating; Triclosan; United States National Institutes of Health; Vulnerable Populations; Wheezing; airway inflammation; antimicrobial; atopy; career; cohort; consumer product; disorder risk; early childhood; early life exposure; environmental chemical; immunotoxicity; improved; infancy; interest; lung development; man; microbial; modifiable risk; novel; post-doctoral training; postnatal; rapid growth; respiratory; respiratory health; sex; skills; skin microbiota; urban area; urinary

PROJECT SUMMARY I am an environmental epidemiologist with primary research interests in the role of early-life chemical exposures on the immune and respiratory systems. The goal of this proposal is to obtain skills needed to further my postdoctoral training in examining early-life chemical exposures and child allergic, respiratory, and immune outcomes. Linking chemical exposures and allergic disease development is important to improve our understanding of modifiable risk factors for childhood atopic diseases, including eczema and asthma. Formal coursework and expert mentorship from Drs. Joseph Braun, Adam Spanier, and George Papandonatos will enable me to acquire the knowledge, skills, and abilities to achieve my long-term career goal of becoming an independent researcher. This training will allow me to pursue independent research aims examining the impact of triclosan exposures on wheeze, eczema, and asthma risks using longitudinal exposure and outcome data in an ongoing cohort. All relevant exposure, covariate, and outcome were previously collected as part of the NIH- funded Health Outcomes and Measures of the Environment (HOME) Study, an ongoing pregnancy and birth cohort study. The primary objectives of this proposal are to rigorously characterize associations of gestational and early-childhood exposure to triclosan with eczema and asthma outcomes in order to identify potential windows of allergic and/or respiratory health susceptibility from triclosan exposure. Specifically, I will 1) train in biomarkers of gestational and childhood triclosan exposure and advanced epidemiologic methods to measure their impacts with Dr. Braun, 2) learn advanced statistical skills with Drs. Papandonatos and Braun: a) in longitudinal and repeated measures analyses to characterize patterns and trajectories of eczema and wheeze, b) to identify susceptible windows to enhance our ability to detect effects and c) to identify vulnerable groups, 3) train in early-childhood allergy development, airway inflammation, and child lung development and physiology with Dr. Spanier, and 4) translate my research and training to position myself for a future K-award. This proposal will address gaps in the understanding of the timing through which triclosan exposure may affect allergic disease development in children. This proposed research and training plan lays the foundation for my independent research career that aims to clarify how early-life exposures to environmental chemicals may be important determinants of asthma and other allergic disease development and the potential biological mechanisms through which they may act.

项目摘要 我是一名环境流行病学家，主要研究兴趣是早期生命化学物质的作用， 对免疫系统和呼吸系统的影响。本计划的目标是获得所需的技能， 进一步我的博士后培训，在检查早期生活的化学品暴露和儿童过敏，呼吸， 免疫结果。将化学品暴露与过敏性疾病的发展联系起来对于改善我们的 了解儿童特应性疾病（包括湿疹和哮喘）的可改变风险因素。正式 约瑟夫·布劳恩博士、亚当·斯潘尼尔博士和乔治·帕潘多纳托斯博士的课程和专家指导将 使我能够获得知识，技能和能力，以实现我的长期职业目标， 独立研究员。这项培训将使我能够进行独立的研究， 三氯生暴露对喘息、湿疹和哮喘风险的影响 一个正在进行的队列。所有相关的暴露、协变量和结局都是先前收集的，作为NIH的一部分。 资助的健康结果和环境措施（HOME）研究，正在进行的怀孕和分娩 队列研究该提案的主要目的是严格描述妊娠相关性， 和儿童早期接触三氯生与湿疹和哮喘的结果，以确定潜在的 暴露于三氯生的过敏和/或呼吸系统健康易感性窗口。具体来说，我将接受以下训练： 妊娠期和儿童期三氯生暴露的生物标志物和先进的流行病学方法， 他们对Braun博士的影响，2）与Papandonatos博士和Braun一起学习高级统计技能：a）在 纵向和重复测量分析以表征湿疹和喘息的模式和轨迹， B）确定易受影响的窗口，以提高我们发现影响的能力，以及c）确定弱势群体， 3)在儿童早期过敏发展、气道炎症和儿童肺部发育方面进行培训， 生理学与博士Spanier，和4）翻译我的研究和培训定位自己为未来的K奖。 该提案将解决在了解三氯生暴露可能影响的时间方面的差距 儿童过敏性疾病的发展。这一研究和培训计划的提出为我奠定了基础， 独立的研究生涯，旨在澄清如何早期生活暴露于环境化学品可能是 哮喘和其他过敏性疾病发展的重要决定因素以及潜在的生物学效应 他们可以采取行动的机制。