Training Program in Lung Biology and Translational Medicine

肺生物学和转化医学培训计划

• 批准号: 9756439
• 负责人: AMIT GAGGAR
• 金额: $ 32.16万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-20 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756439
• 关键词: Biology; Lung; Training Programs; translational medicine

 DESCRIPTION (provided by applicant): The Training Program in Lung Biology and Translational Medicine at the University of Alabama at Birmingham (UAB) provides multidisciplinary training in a stimulating and collaborative environment that nurtures the development of highly competent and innovative biomedical research scientists. This Program, initiated in 2010 to train M.D. or Ph.D. postdoctoral fellows in lung-related research, is currentl in its 4th year with a current allocation of 5 trainees (2-3-4-5-5, for years 1-5). In the first 3. years of the Program, we have graduated three trainees, all in academic research positions, two of the three are in full-time academic research faculty positions and the third receiving advanced post-doctoral training at another institution; with five additional trainees currently in the Progrm. The multidisciplinary and translational approach to the proposed training has been highly successful, and is highlighted by a diverse and interactive group of thirty faculty mentors who hold primary appointments in eight UAB Departments (4 - basic science; 4 - clinical). This includes the successful transition of "junior mentors" to the regular faculty mentoring pool. The faculty mentors are grouped into three thematic areas based on scientific expertise: (1) immunology-microbiology; (2) cell biology-tissue repair; (3) translational sciences. Translational research in statistical genetics, computational biology, biomarker discovery, and drug discovery/development and clinical trials (group 3) will facilitate the clinical translation of basc science research (groups 1 and 2). Based on the existing expertise and ongoing research efforts at UAB, training will focus on the manifestations, diagnosis, risk/prognostic stratificatio, mechanisms, prevention, and treatment of lung diseases, primarily acute lung injury (ALI), cystic fibrosis (CF), asthma, chronic obstructive lung diseases (COPD), and interstitial lung diseases (ILD). Training programs will be highly individualized and tailored to maximize success of each trainee with the creation of individual development plans (IDPs). In addition to the research projects that will be conducted in the mentor's laboratory, training will encompass a highly structured didactic program that includes weekly teaching conferences in the Division of Pulmonary, Allergy and Critical Care Medicine, a "survival skills" curriculum (in collaboration with the UAB Office of Postdoctoral Education) and a Research Core Curriculum that includes emerging themes such as cellular plasticity, drug discovery/development, "big data", computational biology, and personalized medicine. Formal instruction will include the responsible and ethical conduct of research. A priority in the next phase of this Program is the recruitment/retention of underrepresented minorities, and maintaining the current high-rate of trainee retention in academic biomedical research careers.

 描述(由申请人提供)：阿拉巴马大学伯明翰分校(UAB)的肺生物学和转化医学培训计划在激励和协作的环境中提供多学科培训，以培养高能力和创新的生物医学研究科学家的发展。该计划于2010年启动，旨在培训肺部相关研究的医学博士或博士后研究员，目前已进入第四个年头，目前分配给5名学员(1-5年级2-3-4-5)。在该计划的头三年，我们已经完成了三名受训人员的毕业，他们都在学术研究岗位上，其中两人是全职学术研究教员，第三人在另一机构接受高级博士后培训；目前还有五名受训人员正在计划中。对拟议培训的多学科和翻译方法非常成功，由30名教员导师组成的多样化和互动小组突出了这一点，他们在8个UAB部门(4个基础科学部门；4个临床部门)担任初级职务。这包括将“初级导师”成功地过渡到正规的教职员工辅导池。教师导师根据科学专长被分成三个主题领域：(1)免疫学-微生物学；(2)细胞生物学-组织修复；(3)翻译科学。统计遗传学、计算生物学、生物标记物发现、药物发现/开发和临床试验方面的翻译研究(第3组)将促进BASC科学研究的临床翻译(第1组和第2组)。基于UAB现有的专业知识和正在进行的研究工作，培训将侧重于肺部疾病的表现、诊断、风险/预后分层、机制、预防和治疗，主要是急性肺损伤(ALI)、囊性纤维化(CF)、哮喘、慢性阻塞性肺疾病(COPD)和间质性肺疾病(ILD)。培训计划将高度个性化和量身定制，通过制定个人发展计划(IDP)最大限度地提高每个受训者的成功。除了将在导师的实验室进行的研究项目外，培训还将包括一个高度结构化的教学计划，其中包括在肺、过敏和危重护理医学部每周举行的教学会议，一个“生存技能”课程(与UAB博士后教育办公室合作)和一个研究核心课程，其中包括细胞可塑性、药物发现/开发、“大数据”、计算生物学和个性化医学等新兴主题。正式的指导将包括负责任和合乎道德的研究行为。该计划下一阶段的优先事项是招募/保留代表性不足的少数族裔，并在学术生物医学研究职业中保持目前较高的实习生保留率。