Slide Scanner for the ONPRC Imaging and Morphology Core

适用于 ONPRC 成像和形态学核心的载玻片扫描仪

• 批准号: 9492218
• 负责人: Sathya Srinivasan
• 金额: $ 14.57万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-19 至 2019-04-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9492218
• 关键词: Area; Biomedical Research; Core Facility; Enhancement Technology; Evaluation; Funding; Health Sciences; Image; Individual; Interdisciplinary Study; Microscope; Microscopy; Morphology; Oregon; Primates; Reproducibility; Research; Research Personnel; Research Project Grants; Resolution; Scanning; Scientist; Slide; Time; Tissues; United States National Institutes of Health; Universities; cost effective; fluorescence imaging; instrument; light microscopy

PROJECT SUMMARY The Imaging and Morphology Support Core (IMSC) at the Oregon National Primate Research Center (ONPRC) proposes to acquire funds for a fully automated, high-capacity, high-resolution slide scanner that can accommodate both bright-field and fluorescence imaging. The IMSC provides comprehensive, expert, and cost-effective advanced light microscopy support to investigators by providing them access to state-of-the-art microscopy technologies that enhance collaborative, multidisciplinary research. The slide scanner will be located in the microscopy core facility for maximum utilization with expert support from the core staff. Instrument time not used by the ONPRC investigators on this application will be available to other scientists at Oregon Health & Science University, thereby extending the overall benefits. Acquisition of a slide scanner will have a high impact on the biomedical research at ONPRC and will expand the scope of NIH-funded projects. All of the projects detailed in the “Research Projects” section are in need of high-capacity and high- reproducibility scanning for analyses in large tissue areas, covering hundreds of fields of view, rather than the single fields of view acquired on a standard microscope, and involves post-processing of individual images into large montages which require enormous time and effort. After careful evaluation of the commercially available slide scanners in the market and input from the user group, we are requesting funds to purchase an Olympus VS120-6S slide scanner.

项目摘要 俄勒冈州国家灵长类动物研究中心的成像和形态支持核心（IMSC） （ONPRC）建议获得资金，用于全自动，高容量，高分辨率的幻灯片扫描仪， 适应明场和荧光成像。IMSC提供全面的，专业的， 为研究人员提供具有成本效益的先进光学显微镜支持，使他们能够获得最先进的技术 显微技术，加强合作，多学科研究。载玻片扫描仪将 位于显微镜核心设施，在核心工作人员的专家支持下，最大限度地利用。 ONPRC研究人员在本申请中未使用的仪器时间将提供给其他科学家， 俄勒冈州健康与科学大学，从而扩大整体效益。购买载玻片扫描仪将 对ONPRC的生物医学研究产生很大影响，并将扩大NIH资助项目的范围。 在“研究项目”部分详细介绍的所有项目都需要高容量和高- 用于大组织区域分析的再现性扫描，覆盖数百个视场，而不是 在标准显微镜上获取的单个视场，并涉及将单个图像后处理为 这需要大量的时间和精力。在仔细评估了市售的 幻灯片扫描仪在市场和用户群的投入，我们要求资金购买奥林巴斯 VS 120 -6S载玻片扫描仪。