PET-determined prostate brachytherapy dosing using intraoperative image-guidance
使用术中图像引导 PET 确定前列腺近距离放射治疗剂量
基本信息
- 批准号:9505848
- 负责人:
- 金额:$ 62.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-09 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:AlgorithmsAnatomyAssessment toolBrachytherapyCancer ControlCancer EtiologyCancer SurvivorCancerousCessation of lifeClinicalClinical ResearchClinical TrialsComputing MethodologiesDataDevelopmentDiagnosisDoseEdemaExtraprostaticFDA approvedFOLH1 geneFeasibility StudiesFluoroscopyFutureGenerationsGlandHigh-Risk CancerImage-Guided SurgeryImageryImplantIndividualInstitutional Review BoardsLeadMalignant NeoplasmsMalignant neoplasm of prostateNormal tissue morphologyOrganOutcomePET/CT scanPSA screeningPatientsPerformancePhase II Clinical TrialsPhysiciansPositioning AttributePositron-Emission TomographyPostoperative PeriodProceduresProstateProstate Cancer therapyProstaticPublic HealthQuality of lifeQuantitative EvaluationsRadiationRadiation exposureRadioactive Seed ImplantationRandomizedRectumScreening for Prostate CancerSeedsSoftware ToolsSourceStructureSystemTechniquesTissuesToxic effectUltrasonographyUncertaintyUpdateUrethraValidationWorkX-Ray Computed Tomographyantigen bindingbasecancer imagingdisorder controldosimetryfeasibility trialimage guidedimprovedindividual patientmenmortalitypersonalized medicinephase II trialpre-clinicalrandomized trialreconstructionresponsestandard of carestemtargeted imagingtreatment planningtumor
项目摘要
PROJECT SUMMARY/ ABSTRACT
Prostate cancer remains a worldwide public health issue and cause of mortality, with annual diagnosis and
mortality rates exceeding 1.1 billion and 307 million patients, respectively.1 Brachytherapy is widely accepted
and utilized in the management of prostate cancer. Due to recent evidence showing improved disease control
in patients with potentially lethal cancers using approaches incorporating brachytherapy, its utilization is
expected to increase. Successful brachytherapy hinges on adequately dosing prostate while avoiding
excessive radiation to adjacent tissues. Well-recognized contributors to poor dosimetry are source positioning
errors, poor source visualization and edema, which in aggregate lead to regions of excessive as well as
inadequate dose.
In response to the recognized need for dynamic visualization of sources and intraoperative dose analysis
during the procedure, our work has led to the development of a system of intraoperative ultrasound and
fluoroscopy (iRUF) dynamic dose calculation using fluoroscopy-based seed reconstruction and fusion with
intraprocedure ultrasound imaging. Following our pilot feasibility trial, we developed an FDA-approved
dedicated brachytherapy platform, and have confirmed this technique in a Phase II trial, with outstanding
dosimetry on a consistent basis.2,3
Currently, whole-gland treatment is standard in prostate cancer therapy. The need for whole-gland
treatment stems from the uncertainty and difficulty in precisely identifying tumor foci within. Unfortunately, such
approaches inevitably result in radiation exposure of adjacent critical structures, with potential toxicity and
permanent quality of life effects. As long as whole gland therapy is delivered, the ability to limit normal tissue
doses remains constrained by their proximity. New advances in PET imaging targeting Prostate Specific
Membrane Antigen (PSMA) and second-generation PSMA-binding agents now allow highly specific and
sensitive identification of extraprostatic and intraprostatic tumors.4,5,6 Focal therapy using PSMA PET/CT-and
dynamic dosimetry-guided seed placement promises to further improve the standard of care in brachytherapy,
allowing the physician to precisely tailor the dose to the individual’s tumor. This requires precise tumor
imaging combined with dynamic intra-operative localization of the implant in relation to the target volume, as
well as surrounding uninvolved prostate and normal anatomy.7,8,9,10 Combining iRUF and PSMA PET/CT would
break new ground through addition of precise targeting via purely computational methods.
We aim to develop a clinically feasible image-guidance platform for dynamic, quantitative evaluation of
partial-gland, focal dosimetry during brachytherapy. The system would allow personalized brachytherapy,
achieving excellent cancer control while avoiding unnecessary toxicity for prostate cancer survivors.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Everette C Burdette其他文献
Everette C Burdette的其他文献
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{{ truncateString('Everette C Burdette', 18)}}的其他基金
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
10449277 - 财政年份:2018
- 资助金额:
$ 62.81万 - 项目类别:
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
9757727 - 财政年份:2018
- 资助金额:
$ 62.81万 - 项目类别:
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
10255514 - 财政年份:2018
- 资助金额:
$ 62.81万 - 项目类别:
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
10004592 - 财政年份:2018
- 资助金额:
$ 62.81万 - 项目类别:
Image-Guided Transurethral HIFU for Genitourinary Therapy
图像引导经尿道 HIFU 泌尿生殖治疗
- 批准号:
9049577 - 财政年份:2015
- 资助金额:
$ 62.81万 - 项目类别:
Image-Guided Transurethral HIFU for Genitourinary Therapy
图像引导经尿道 HIFU 泌尿生殖治疗
- 批准号:
10259640 - 财政年份:2015
- 资助金额:
$ 62.81万 - 项目类别:
Image-Guided Transurethral HIFU for Genitourinary Therapy
图像引导经尿道 HIFU 泌尿生殖治疗
- 批准号:
10452639 - 财政年份:2015
- 资助金额:
$ 62.81万 - 项目类别:
Robotic System with Multiplexed DOF Control for Minimally Invasive Interventions
用于微创干预的具有多自由度控制的机器人系统
- 批准号:
8253123 - 财政年份:2012
- 资助金额:
$ 62.81万 - 项目类别:
PET-determined prostate brachytherapy dosing using intraoperative image-guidance
使用术中图像引导 PET 确定前列腺近距离放射治疗剂量
- 批准号:
9382210 - 财政年份:2010
- 资助金额:
$ 62.81万 - 项目类别:
PET-determined prostate brachytherapy dosing using intraoperative image-guidance
使用术中图像引导 PET 确定前列腺近距离放射治疗剂量
- 批准号:
9924500 - 财政年份:2010
- 资助金额:
$ 62.81万 - 项目类别:
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