2019 Hormone-Dependent Cancers Gordon Research Conference and Gordon Research Seminar

2019激素依赖性癌症戈登研究会议暨戈登研究研讨会

• 批准号: 9760128
• 负责人: Steffi Oesterreich
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-04 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9760128
• 关键词: Area; Awareness; Beds; Big Data; Biological; Biology; Breast; Clinical; Clinical Trials; Collaborations; Communication; Communities; Discipline; Drug resistance; Endocrine; Ensure; Event; Fertilization; Goals; Gynecology; Hormones; Immunooncology; Industry; International; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of prostate; Medicine; Mentors; Modeling; Neoplasm Metastasis; Pathway interactions; Postdoctoral Fellow; Prostate; Receptor Signaling; Research; Research Personnel; Resistance; Science; Scientist; Senior Scientist; Shapes; Steroid Receptors; Survival Rate; Therapeutic; Training; Update; Woman; career; career development; clinical application; clinical development; clinically relevant; experience; graduate student; hormonal signals; insight; malignant breast neoplasm; meetings; men; novel; posters; success; symposium

PROJECT SUMMARY The Gordon Research Conference (GRC) and the associated Gordon Research Seminar (GRS) on “Hormone Dependent Cancer” build on the success of three prior GRC conferences on this topic in 2013, 2015, and 2017. The 2019 GRC on “Hormone-Dependent Cancers: Small and Big Data” will continue with a focus on bed-to-bedside science, including presentation on novel targets and pathways in breast, prostate, gynecological and other cancers. We will present historical perspectives on targeting hormone-dependent cancers, and importantly will include state-of-the-art approaches, such as the use of “Big Data” and immune oncology studies. Early stage and experienced investigators, academic, and industry representatives will present. The GRS entitled “Overcoming Metastasis and Endocrine Resistance in Hormone Positive Cancers: Beyond Classical Receptor Signaling” will be preceding the GRC, and is specifically geared towards early- career researchers (ECRs; including graduate students, post-docs, and clinical fellows). Leading national and international speakers will present research that represents the entire spectrum from basic biology to clinical application of the biological findings. The focus of the meeting is hormone dependent cancers, with an emphasis on breast and prostate cancer, since 75% of all breast cancers and all prostate cancers are deemed hormone dependent. The presentations will be divided among a total of 9 sessions: Keynote Session 1: Historical perspective, and modelling hormone action; Session 2: What's new in targeting steroid receptors? Session 3: Immune Oncology in hormone-dependent cancers; Session 4: Computational approaches and Big Data; Session 5: Functional and clinical insight into gynecological cancers; Session 6: Novel targets and clinical trials; Session 7: Early-career investigators; Session 8: Key areas and question in Hormones & Cancer; Keynote Session 2: Industry perspective. The goals and aims of the 2019 GRC/GRS are as follows: 1. Present and discuss the newest discoveries associated with hormone-dependent cancers 2. Provide historical perspective on targeting hormone signalling to treat cancer 3. Discuss models for state-of-the-art research on hormone dependent cancers 4. Provide update on success and hurdles for clinical developments of basic biology findings 5. Emphasize convergence of disciplines in the studies of hormone-dependent cancers 6. Facilitate communication and collaboration among ECRs, and with senior scientists and mentors. 7. Promote discussions on career development, including how to tackle biases

项目概要 戈登研究会议（GRC）和相关的戈登研究研讨会（GRS）关于“激素” 依赖性癌症”以 2013 年、2015 年和 2015 年关于该主题的三场 GRC 会议的成功为基础 2017年。2019年GRC“激素依赖性癌症：小数据和大数据”将继续关注 床边科学，包括介绍乳腺癌、前列腺、 妇科癌症和其他癌症。我们将介绍针对激素依赖性药物的历史观点 癌症，重要的是将包括最先进的方法，例如使用“大数据”和免疫 肿瘤学研究。早期和经验丰富的研究人员、学术界和行业代表将 展示。 GRS 的标题是“克服激素阳性癌症的转移和内分泌抵抗： 超越经典受体信号传导”将在 GRC 之前进行，专门针对早期- 职业研究人员（ECR；包括研究生、博士后和临床研究员）。 国内和国际领先的演讲者将介绍代表整个领域的研究 基础生物学到生物学发现的临床应用。会议的焦点取决于激素 癌症，特别是乳腺癌和前列腺癌，因为 75% 的乳腺癌和前列腺癌 癌症被认为依赖于激素。演讲将分为总共 9 个会议： 主题演讲 1：历史视角和激素作用建模；第 2 场：定位方面的新变化 类固醇受体？第三节：激素依赖性癌症的免疫肿瘤学；第四节：计算 方法和大数据；第五节：妇科癌症的功能和临床洞察；第六节： 新靶点和临床试验；第 7 节：早期职业调查员；第八节：关键领域和问题 激素与癌症；主题演讲 2：行业视角。 2019年GRC/GRS的目标和目标如下： 1. 展示并讨论与激素依赖性癌症相关的最新发现 2. 提供靶向激素信号传导治疗癌症的历史观点 3. 讨论激素依赖性癌症的最新研究模型 4. 提供基础生物学发现临床开发的成功和障碍的最新信息 5. 强调激素依赖性癌症研究的学科融合 6. 促进 ECR 之间以及与资深科学家和导师之间的沟通与合作。 7. 促进关于职业发展的讨论，包括如何解决偏见