The impact of parent training on at-risk children's biomarkers of aging

家长培训对高危儿童衰老生物标志物的影响

• 批准号: 9760552
• 负责人: Alexandra D W Sullivan
• 金额: $ 4.5万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9760552
• 关键词: Accounting; Address; Adolescent; Adult; Aftercare; Aging; Attenuated; Award; Behavior Therapy; Behavioral; Biological; Biological Aging; Biological Markers; Cardiovascular Diseases; Caregivers; Cell Aging; Cessation of life; Child; Child Behavior; Child Development; Child Rearing; Childhood; Chronic Disease; Conflict (Psychology); Control Groups; Data Analytics; Development; Developmental Delay Disorders; Disease; Early Intervention; Ecosystem; Environment; Epigenetic Process; Evidence based intervention; Exposure to; Family; Fellowship; Financial Hardship; Future; Grant; Health; Heart Diseases; Intervention; Length; Link; Literature; Longevity; Malignant Neoplasms; Mediating; Mental Depression; Mental disorders; Methods; Modeling; Outcome; Outcome Measure; Parents; Pathway interactions; Postdoctoral Fellow; Poverty; Preparation; Prevention; Prevention program; Preventive Intervention; Psychopathology; Public Health; Randomized; Randomized Controlled Trials; Research; Research Project Grants; Research Training; Rewards; Risk; Risk Factors; Role; Sampling; Skin; Societies; Stress; Systems Theory; Telomere Shortening; Testing; Time; Training; Training Programs; Work; base; career; caregiving; control trial; cost; design; disorder risk; early childhood; early life adversity; efficacy testing; evidence base; experience; follow-up; group intervention; improved; informant; intervention program; mortality; parental role; physical conditioning; pre-doctoral; prevent; primary caregiver; prospective; psychologic; societal costs; stressor; telomere; trial design

PROJECT SUMMARY Many children growing up in adversity experience current and future negative psychological (e.g., mental illness) and physical health (e.g., chronic disease and early mortality) outcomes. Research indicates existing interventions may aid in preventing these outcomes, mitigating their substantial societal cost. Further, several biomarkers observable in children are prospectively associated with negative health outcomes. Accordingly, this predoctoral fellowship award supports the PI’s research training in preparation for a career focused on studying the relationship between adversity, biomarkers of poor health (i.e., accelerated aging), and whether parenting can be leveraged to disrupt this relationship among at-risk children. The research project aims to significantly advance understanding of parenting behavior in the context of high levels of cumulative risk (i.e., when a family/child must cope with multiple, additive stressors). Additionally, this study will test whether improving parenting is related to improvements in biomarkers that forecast poor health outcomes, measured using two biomarkers of accelerated aging (i.e., telomere length and the epigenetic clock). This project aims to test a comprehensive conceptual model (refer to Figure 1 in the Research Strategy section) in a sample of 150 children with developmental delay who are participating in a trial testing the efficacy of a behavioral parenting intervention. This model posits that the use of an evidence-based intervention to improve parenting will disrupt the pathway between cumulative risk and biomarkers of accelerated aging. Consistent with Ecological Systems Theory, which underscores the central role of the caregiver in early childhood development, the proposed conceptual model posits that (a) higher levels of cumulative risk will be associated with accelerated biological aging and (b) improvements in parenting will ameliorate this relationship, such that higher quality parenting will disrupt the pathway between cumulative risk and accelerated biological aging. In order to provide a robust test of the conceptual model, this study will leverage an existing randomized controlled trial design as well as use a multi-informant and method framework. The proposed conceptual model will provide the necessary evidence for future work examining physical health in the context of family-based interventions in young children, and whether intervening early in development can prevent future risk of poor physical health. This study will lay the groundwork for additional longitudinal tests (i.e., longer time-frame, follow-ups later continuing later in the life span) of biological outcomes of adversity, and whether behavioral interventions influence biomarkers as well as health outcomes among at-risk, underserved families.

项目摘要 许多在逆境中成长的孩子经历了当前和未来的消极心理（例如，心理 疾病）和身体健康（例如，慢性疾病和早期死亡率）结果。研究表明，现有 干预措施可能有助于防止这些结果，减少其巨大的社会成本。此外，若干 在儿童中可观察到的生物标志物与负面健康结果前瞻性相关。因此，委员会认为， 这个博士前奖学金支持PI的研究培训，为职业生涯做准备，重点是 研究逆境，健康状况不佳的生物标志物（即，加速老化），以及 可以利用父母的养育来破坏有风险儿童之间的这种关系。该研究项目旨在 在高水平累积风险的背景下，显著推进对育儿行为的理解（即， 当一个家庭/孩子必须科普多重的、附加的压力源时）。此外，这项研究将测试是否 改善养育关系与预测不良健康结果的生物标志物的改善有关， 使用加速衰老的两种生物标志物（即，端粒长度和表观遗传时钟）。该项目旨在 在150个样本中测试一个全面的概念模型（参见研究策略部分的图1） 参与测试行为养育有效性试验的发育迟缓儿童 干预该模型假定，使用基于证据的干预措施来改善养育方式， 加速老化的累积风险和生物标志物之间的途径。符合生态系统 该理论强调了照顾者在儿童早期发展中的核心作用， 概念模型假设：（a）较高水平的累积风险将与生物加速相关 老龄化和（B）父母教养的改善将改善这种关系，因此，更高质量的父母教养将 破坏累积风险和加速生物老化之间的途径。为了提供可靠的测试 在概念模型中，本研究将利用现有的随机对照试验设计，并使用 多信息源和方法框架。拟议的概念模型将提供必要的证据 今后在幼儿家庭干预的背景下研究身体健康的工作，以及 在发育早期进行干预是否可以预防未来身体健康不良的风险。这项研究将奠定 附加纵向测试的基础（即，更长的时间框架，后续行动后继续在以后的生活 span）逆境的生物学结果，以及行为干预是否也会影响生物标志物 作为高危家庭的健康结果，服务不足。