Coding of head kinematics during locomotor behavior

运动行为期间头部运动学的编码

• 批准号: 9759915
• 负责人: LARRY F HOFFMAN
• 金额: $ 19.5万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-08 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9759915
• 关键词: Achievement; Acoustics; Action Potentials; Address; Adult; Afferent Neurons; Animal Model; Animals; Area; Behavior; Behavior Therapy; Behavioral; Characteristics; Chinchilla (genus); Chronic; Code; Crista ampullaris; Data; Data Storage and Retrieval; Development; Diagnosis; Duct (organ) structure; Electrodes; Electrophysiology (science); Epithelium; Exhibits; Feedback; Foundations; Freedom; Future; Glean; Goals; Head; Head Movements; Individual; Investigation; Knowledge; Laboratories; Labyrinth; Link; Locomotion; Maps; Measures; Methods; Modality; Mosses; Motion; Movement; National Institute on Deafness and Other Communication Disorders; Neuraxis; Output; Pattern; Perception; Perilymph; Peripheral; Pharmacotherapy; Pilot Projects; Positioning Attribute; Preclinical Testing; Preparation; Prevention; Research; Research Priority; Response to stimulus physiology; Rodent; Role; Rotation; Seminal; Sensory; Signal Transduction; Smell Perception; Space Perception; Spinal; Stimulus; Strategic Planning; Study models; Technology; Testing; Training; Transcend; Utricle structure; Vertebrates; Vestibular Nerve; Vision; Visual; awake; base; facsimile; gaze; improved; insight; kinematics; method development; middle ear; neurophysiology; novel; public health relevance; response; satisfaction; sensor; sensory integration; sensory system; sex; somatosensory; stimulus processing; transmission process; vestibulo-ocular reflex; way finding

Project Summary The vestibular sensory epithelia encode dynamic and static head movements in trains of action potentials that project to the central nervous system along primary afferent neurons. These signals provide the principal drive for behaviors such as the vestibulo-ocular reflex, which functions to stabilize visual gaze during head movements associated with dynamic behaviors, particularly during locomotion. While the response dynamics of vestibular afferents have been widely studied in a variety of animal models, the input/output relations have been limited to preparations that are restrained and/or anesthetized. Recent investigations using lower vertebrates have shown that peripheral vestibular stimulus processing is modulated by centrifugal efferent feedback driven by rostrally-projecting efference copy originating in spinal locomotor pattern generators. Therefore, critical insight into behaviorally-relevant peripheral vestibular stimulus processing would be gleaned under conditions of awake, behaving preparations. At present, data collected under these conditions do not exist. Therefore, such information requires the development of preparations in which the dynamic response characteristics of vestibular afferent neurons are investigated under conditions of natural locomotion. The present proposal aims to achieve this goal through the development of methods to record from individual vestibular afferent neurons in behaving chinchillas, agile rodents commonly used in studies of peripheral vestibular neurophysiology. There are two factors that support the use of this animal model for these studies: 1) the superior vestibular nerve can be accessed from the middle ear, precluding the need for an intracranial approach to the afferents; and 2) these animals tolerate chronic preparations very well. Critical to this project is the availability of a miniature electrophysiology platform that incorporates a 9 degree-of-freedom movement sensor along with a multichannel electrode headstage and on-board data storage. This hardware will enable the direct correlation of afferent discharge during head movements that occur during unrestrained natural locomotion. The successful development of these methods in an agile animal model will provide the foundation for future investigations of vestibular afferent dynamics under a variety of behavioral and treatment conditions, and will transcend the limitations of imposed upon our understanding of head movement coding by the constraints of passive stimulus presentation in restrained and/or anesthetized conditions. In so doing, the research aims of this application address the Functional Connectivity topic of research Priority Area 1 of the NIDCD Strategic Plan. In addition, the methods developed are seminal to understanding the role of vestibular sensory contributions to spatial navigation and orientation behaviors, and as such address other critical research priorities as identified in the Strategic Plan.

项目摘要 前庭感觉上皮以动作电位序列编码动态和静态头部运动 沿着初级传入神经元投射到中枢神经系统。这些信号提供了 前庭眼反射：对前庭眼反射等行为的驱动力，其功能是在头部运动时稳定视觉凝视 与动态行为相关的运动，特别是在运动期间。虽然反应动力学 前庭传入的输入/输出关系已经在各种动物模型中被广泛研究， 仅限于受约束和/或麻醉的制剂。最近的调查使用较低的 脊椎动物已经表明，外周前庭刺激处理是由离心传出调制的， 由源自脊髓运动模式发生器的喙状投射传出复制驱动的反馈。 因此，关键的洞察行为相关的外周前庭刺激处理将收集 在清醒的情况下，做好准备。目前，在这些条件下收集的数据并不 存在.因此，此类信息需要制定动态响应的准备工作 在自然运动条件下研究前庭传入神经元的特性。的 目前的建议旨在通过发展从个人记录的方法来实现这一目标。 行为龙猫的前庭传入神经元，通常用于外周神经系统研究的敏捷啮齿动物 前庭神经生理学有两个因素支持将该动物模型用于这些研究： 1)上级前庭神经可以从中耳进入，从而排除了颅内 接近传入; 2）这些动物耐受慢性制剂非常好。对这个项目至关重要 是一个微型电生理平台的可用性， 传感器沿着以及多通道电极头台和机载数据存储器。这个硬件将使 在头部运动过程中传入放电的直接相关性，发生在无限制的自然 运动这些方法在敏捷动物模型中的成功开发将提供 为将来在各种行为和治疗下研究前庭传入动力学奠定了基础 条件，并将超越限制强加于我们的理解头部运动编码， 在约束和/或麻醉条件下被动刺激呈现的约束。这样做 本申请的研究目的是解决研究优先领域1的功能连接性主题。 NIDCD战略计划。此外，所开发的方法对于理解前庭的作用是开创性的。 空间导航和定向行为的感官贡献，并因此解决其他关键问题， 战略计划中确定的研究重点。

项目成果

Inflight head stabilization associated with wingbeat cycle and sonar emissions in the lingual echolocating Egyptian fruit bat, Rousettus aegyptiacus.

• DOI: 10.1007/s00359-021-01518-x
• 发表时间: 2021-11
• 期刊: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
• 作者: Rossborough J;Salles A;Stidsholt L;Madsen PT;Moss CF;Hoffman LF
• 通讯作者: Hoffman LF