Mechanisms of Action of MBCT-PD: A Pilot Study

MBCT-PD 的作用机制：初步研究

• 批准号: 9759771
• 负责人: Kristen L Mackiewicz Seghete
• 金额: $ 23.1万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-08 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9759771
• 关键词: Affect; Age-Months; Behavioral; Behavioral Mechanisms; Brain; Brain region; Child Rearing; Cognitive; Detection; Development; Emotional; Fostering; Functional Magnetic Resonance Imaging; Generations; Group Therapy; High Risk Woman; Individual; Infant; Intention; Intervention; Major Depressive Disorder; Measures; Medial; Mental Depression; Mental Health; Modeling; Mothers; Parietal; Pathway interactions; Pilot Projects; Postpartum Depression; Postpartum Period; Predisposition; Prefrontal Cortex; Pregnancy; Process; Psychopathology; Questionnaires; Recording of previous events; Reporting; Risk; Sampling; Stimulus; Task Performances; Time; Woman; Work; base; cognitive control; depressive symptoms; emotion regulation; evidence base; experience; infant outcome; innovation; intergenerational; intervention effect; maternal depression; mindfulness; mindfulness based cognitive therapy; neuromechanism; peripartum depression; prenatal; prevent; public health relevance; relating to nervous system; repository; skills; transmission process; treatment as usual

Modified Project Summary/Abstract Section Project Summary Postpartum depression is one of the most pervasive types of psychopathology postpartum, with detrimental effects for both mothers and their infants. There are a limited number of non-pharmacological interventions at present, particularly interventions developed to reduce risk of postpartum depression in at-risk samples (e.g., women with a prior history of depression). Elucidating the mechanisms of action of efficacious treatments that reduce postpartum depression is critical, as it will facilitate understanding what mechanisms are engaged and how intervention during pregnancy can optimize engagement of these mechanisms. This pilot translational fMRI study proposes to examine whether cognitive control and emotion regulation are potential mechanisms of action during the postpartum period, both at the behavioral and neural level, of Mindfulness-Based Cognitive Therapy – Perinatal Depression (MBCT-PD). MBCT-PD is a group-based therapy that focuses on developing mindfulness and cognitive behavioral skills and has been shown to be efficacious in reducing depressive symptoms and emergence of major depressive disorder postpartum. Additionally, the study proposes to explore whether engagement of potential mechanisms of action effect intergenerational transmission of risk, namely reported negative infant emotionality.

修改后的项目摘要/摘要部分 项目摘要 产后抑郁症是产后最普遍的精神病理类型之一，对母亲和婴儿都有不利影响。目前，非药理学干预措施的数量有限，特别是为减少高危样本(例如，有抑郁症病史的妇女)的产后抑郁风险而开发的干预措施。阐明减少产后抑郁的有效治疗的作用机制至关重要，因为这将有助于理解哪些机制参与，以及怀孕期间的干预如何优化这些机制的参与。这项实验性的翻译功能磁共振成像研究旨在研究认知控制和情绪调节是否是基于正念的认知疗法-围产期抑郁(MBCT-PD)产后在行为和神经水平上的潜在作用机制。MBCT-PD是一种以小组为基础的治疗方法，专注于发展正念和认知行为技能，已被证明在减少抑郁症状和产后出现严重抑郁障碍方面有效。此外，这项研究建议探索潜在的行动机制的参与是否会影响风险的代际传递，即报告的婴儿负面情绪。