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Prototype optical device for image guided surgery with panitumumab-IRDye800

用于使用帕尼单抗-IRDye800进行图像引导手术的原型光学装置

基本信息

批准号：
9759821
负责人：
EBEN L. ROSENTHAL
金额：
$ 42.01万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-10 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9759821
关键词：
Antibodies Biological Markers Cancer Detection Cetuximab Clinical Protocols Clinical Trials Collaborations Consumption Contrast Media Cutaneous Cyclic GMP Data Detection Development Device Designs Devices Diagnostic Disease Dose Drug Utilization Dyes Epidermal Growth Factor Receptor Excision Explosion FDA approved Fc Receptor Fluorescence Fluorescence Angiography Frozen Sections Hand Head and Neck Cancer Human Image Image-Guided Surgery Imagery Imaging Device Indocyanine Green Infusion procedures Label Lymphatic Malignant Neoplasms Measures Microscopic Mind Operating Rooms Operative Surgical Procedures Optics Pathologic Perfusion Phase Phase I Clinical Trials Pre-Clinical Model Reaction Resected Role Safety Sampling Sensitivity and Specificity Skin Source Standardization Surgeon Surgical Oncology Survival Rate System Techniques Testing Therapeutic Therapeutic Agents Therapeutic antibodies Time Tissues Toxic effect Toxicology Translations Validation cancer type clinical translation density design first-in-human head and neck cancer patient image guided imaging agent imaging platform imaging system improved in vivo instrument intravenous administration medication safety meetings microscopic imaging nonhuman primate novel optical imaging panitumumab perfusion imaging phantom model phase 1 study pre-clinical programs prototype public health relevance routine imaging safety testing targeted agent tumor tumor specificity wound

项目摘要

DESCRIPTION (provided by applicant): Evidence from our lab and others has demonstrated the potential of fluorescently labeled antibodies to measure microscopic disease to guide surgical intervention preclinical models. We present novel data demonstrating safety of the fluorescently labeled anti-EGFR antibody in non- human primates and humans. We propose a clinical trial in collaboration with Novadaq to develop a prototype intraoperative imaging device for use in a first in human clinical trial with fluorescently labeled panitumumab. The trial will b designed to test safety of the drug and determine if the camera can detect subclinical cancer in the operating room to guide surgical resection of head and neck cancer. The cGMP manufacture of panitumumab-dye is being completed by the NCI NExT program.

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Regulatory Aspects of Optical Methods and Exogenous Targets for Cancer Detection.

光学方法和外源性靶标的调节方面用于癌症检测。

DOI：
10.1158/0008-5472.can-16-3217
发表时间：
2017-05-01
期刊：
Cancer research
影响因子：
11.2
作者：
Tummers WS;Warram JM;Tipirneni KE;Fengler J;Jacobs P;Shankar L;Henderson L;Ballard B;Pfefer TJ;Pogue BW;Weichert JP;Bouvet M;Sorger J;Contag CH;Frangioni JV;Tweedle MF;Basilion JP;Gambhir SS;Rosenthal EL
通讯作者：
Rosenthal EL

Endoscopic Fluorescence-Guided Surgery for Sinonasal Cancer Using an Antibody-Dye Conjugate.

DOI：
10.1002/lary.28483
发表时间：
2020-12
期刊：
The Laryngoscope
影响因子：
0
作者：
Hart ZP;Nishio N;Krishnan G;Lu G;Zhou Q;Fakurnejad S;Wormald PJ;van den Berg NS;Rosenthal EL;Baik FM
通讯作者：
Baik FM

ASO Author Reflections: Fluorescent-Guided Surgery to Augment Pancreatic Cancer Surgery.