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Imaging Guided Surgery using Fluorescently Labeled Cetuximab

Imaging Guided Surgery using Fluorescently Labeled Cetuximab
使用荧光标记的西妥昔单抗进行影像引导手术
批准号：
8765574
负责人：
EBEN L. ROSENTHAL
金额：
$26.81万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-07-01 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8765574
关键词：
AntibodiesBedsBlindedCetuximabCharacteristicsClinicClinical TrialsDataData AnalysesDetectionDevelopmentDiagnosticDiseaseDoseEGFR Protein OverexpressionEpidermal Growth Factor ReceptorEpitheliumEquipmentExcisionExplosionFDA approvedFluorescenceFrozen SectionsFundingHead and Neck CancerHumanImageImage-Guided SurgeryImageryImaging DeviceInflammatoryInstitutional Review BoardsLabelMalignant NeoplasmsMeasuresMicroscopicModelingOperating RoomsOperative Surgical ProceduresOutcomePatient SchedulesPatientsPre-Clinical ModelPrimary NeoplasmProceduresRecruitment ActivityResectedSafetySamplingSensitivity and SpecificitySpecimenSurgeonSurvival RateSystemTechniquesTherapeuticTherapeutic AgentsTherapeutic UsesTimeTissuesTongue NeoplasmsToxic effectTranslationsTumor Tissuecancer surgerycancer typeimprovedin vivoinnovationintraoperative imagingintravenous administrationnonhuman primatenoveloncologyoptical imagingpre-clinicalpublic health relevancereceptor expressionstandard of caretumortumor specificitywound

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DESCRIPTION (provided by applicant): Evidence from our lab and others has demonstrated the potential of fluorescently labeled antibodies to measure microscopic disease to guide surgical intervention preclinical models. We present novel data demonstrating safety of the fluorescently labeled anti- EGFR antibody in non-human primates. We propose a clinical trial with fluorescently labeled cetuximab to detect subclinical cancer in the operating room existing imaging equipment to guide surgical resection of head and neck cancer. The proposed trial has received IRB and IND approval in September 2013.
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会议论文
American Head and Neck International Conference
Targeted Dual Modality Imaging for Detection and Removal of Head and Neck Cancer
Targeted Dual Modality Imaging for Detection and Removal of Head and Neck Cancer
Next Generation Sentinel Node Mapping
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