MUSC Digestive Disease Research Core Center

MUSC消化疾病研究核心中心

• 批准号: 9889232
• 负责人: DON C. ROCKEY
• 金额: $ 108.76万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9889232
• 关键词: Area; Award; Basic Science; Biology; Biomedical Research; Cell model; Cells; Clinical; Clinical Research; Clinical Sciences; Collaborations; Colon; Complement; Core Facility; Curiosities; Development; Digestive System Disorders; Disease; Ensure; Esophagitis; Esophagus; Evaluation; Fibrosis; Fostering; Foundations; Functional disorder; Funding; Gastrointestinal Diseases; Gastrointestinal tract structure; Goals; Health; Healthcare; Hepatocyte; Image; Imaging Techniques; Inflammation; Inflammatory Bowel Diseases; Injury; Investigation; Investments; Lead; Leadership; Liver; Liver diseases; Malignant Neoplasms; Mass Spectrum Analysis; Medical; Mentorship; Mission; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Organ; Pancreas; Participant; Pathogenesis; Patient-Focused Outcomes; Patients; Performance; Process; Proteomics; Research; Research Infrastructure; Research Personnel; Resources; Scholarship; Science; Scientific Inquiry; Small Intestines; South Carolina; Stomach; Structure; Tissues; Translating; Translational Research; Universities; Vision; Work; base; career development; cell injury; chronic pancreatitis; design; driving force; flexibility; gastrointestinal; human disease; human model; imaging capabilities; improved; innovation; instrumentation; liver injury; member; novel; novel therapeutics; organ injury; programs; research study; success; tissue culture

Center Overview - Abstract The vision for the Medical University of South Carolina (MUSC) Digestive Disease Research Core Center (DDRCC) is to create a culture of curiosity, scholarship, and investigation around our central theme. Our theme is informed by the pathogenesis of disease in the gastrointestinal tract, from cellular injury, inflammation, fibrosis, and ultimately end organ dysfunction and disease. Our specific emphasis on human disease is part of our rationale for the extension of the continuum of our theme - from injury to disease. Further, we expect the work by Center members to lead to new treatments for patients with gastrointestinal disease. Our specific aims are integrated with the specific goal to serve our Research Base/Full Members and our mission; specific aims are as follows: (1) First, we will foster collaboration among digestive and liver disease researchers. We will leverage collaborations among MUSC investigators to further augment our research capacity while ensuring the success of a critical mass of outstanding researchers in digestive and liver diseases. This will be supported through multiple synergistic efforts as described in the Administrative Core including DDRCC leadership and Enrichment and Pilot and Feasibility Programs. (2) We will develop sustainable scientific core resources that will specifically support digestive and liver disease studies while leveraging institutional investments. The DDRCC scientific cores include: a) Analytical Cell Models Core, which will deliver high quality, pure primary liver cells and produce state-of-the-art tissue culture models; b) Advanced Imaging Core with advanced cell- and tissue-based imaging techniques and instrumentation; and c) Proteomics Core with innovative mass spectrometry imaging capabilities. These cores are complemented by a committed Clinical Component which provides support for the design, implementation and analysis of research studies to improve clinical outcomes for patients with digestive diseases. Finally, we will (3) Promote the long- term success and sustainability of the DDRCC through dedicated mentorship of New Investigators, a rigorous Center evaluation and process improvement strategy, mission alignment with other centers at MUSC, and specific long-term institutional commitments to the Center. The MUSC DDRCC is made up of 29 Full Members focused specifically on our theme, and who constitute our Research Base of $10.8M. We also have 31 Associate Members who are active participants in the Center. The DDRCC has enormous potential to answer important questions, open new areas for further inquiry, and result in potential new therapeutic discoveries that will be translated to new treatments for patients with digestive and liver disease.

中心概述-摘要 南卡罗来纳医科大学消化疾病研究核心中心的愿景 (DDRCC)是围绕我们的中心主题创造一种好奇心、学术和调查的文化。我们的主题 从胃肠道疾病的发病机制，从细胞损伤，炎症，纤维化， 并最终结束器官功能障碍和疾病。我们对人类疾病的特别强调是我们 我们主题的连续体--从伤害到疾病--的延展的理由。此外，我们期待着这项工作 由中心成员引领胃肠道疾病患者的新疗法。 我们的具体目标与具体目标相结合，为我们的研究基地/正式成员和我们的使命服务； 具体目标如下：(一)促进消化与肝脏疾病的协作 研究人员。我们将利用MUSC调查人员之间的合作来进一步加强我们的研究 在提高能力的同时，确保一大批消化和肝病领域的杰出研究人员取得成功。 这将通过行政核心中所述的多种协同努力来支持，包括 发改委的领导力和充实以及试点和可行性方案。(二)坚持可持续发展 科学核心资源，将专门支持消化和肝病研究，同时 利用机构投资。DDRCC科学核心包括：a)分析单元模型核心， 将提供高质量、纯净的原代肝细胞，并生产最先进的组织培养模型；b) 具有先进的基于细胞和组织的成像技术和仪器的先进成像核心；以及c) 具有创新的质谱学成像能力的蛋白质组学核心。这些核心由一个 承诺的临床组件，为研究的设计、实施和分析提供支持 旨在改善消化系统疾病患者临床结果的研究。最后，我们将(3)推动长期- 通过对新调查人员的专注指导，DDRCC的任期成功和可持续性，严格的 中心评估和流程改进战略，与南加州大学其他中心的使命协调，以及 对该中心的具体长期机构承诺。 MUSC DDRCC由29名正式成员组成，他们专门关注我们的主题，他们构成了我们的 1080万美元的研究基础。我们还有31名准会员，他们是该中心的积极参与者。这个 DDRCC具有巨大的潜力来回答重要问题，开辟新的领域进行进一步调查，并导致 潜在的治疗新发现，将转化为消化系统疾病患者的新疗法 肝病。