SAMIPS-NPC: Southern Africa Mother Infant Pertussis Study, Nasopharyngeal Carriage

SAMIPS-NPC：南部非洲母婴百日咳研究，鼻咽运输

• 批准号: 9761440
• 负责人: Christopher J GILL
• 金额: $ 72.55万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761440
• 关键词: Address; Advisory Committees; Affect; African; Age; Animals; Birth; Birth Intervals; Bordetella pertussis; Boston; Carrier State; Catalogs; Cells; Centers for Disease Control and Prevention (U.S.); Cessation of life; Childhood; Childhood Acute Lymphocytic Leukemia; Clinical; Cohort Studies; Collection; Communicable Diseases; Conjugate Vaccines; Country; Data; Diagnostic; Disease; Effectiveness; Enrollment; Epidemiology; Event; Evolution; Failure; Foundations; Frequencies; Funding; HIV; Haemophilus influenzae; Herd Immunity; Household; Human; Immunization; Immunology; Incidence; Incubated; Individual; Infant; Lead; Libraries; Life; Longitudinal Studies; Longitudinal cohort study; Mathematics; Measures; Modeling; Mothers; Neisseria meningitidis; Newborn Infant; Nuclear Pore Complex; Papio; Participant; Pattern; Pertussis; Pertussis Vaccine; Policies; Population; Postpartum Period; Prevalence; Public Health; Research; Research Personnel; Resources; Rest; Risk; Role; Sampling; Sampling Studies; Selection Bias; Southern Africa; Specific qualifier value; Streptococcus pneumoniae; Swab; Symptoms; Time; Update; Vaccinated; Vaccination; Vaccines; Zambia; base; cohort; design; experience; insight; mathematical model; neonatal infection; prevent; sample collection; theories; transmission process; uptake; vaccinology; willingness

Project Summary Whooping cough, caused by Bordetella pertussis, is one of the most contagious of all contagious diseases, and the least well controlled of all vaccine preventable pediatric diseases. Since switching to acellular pertussis (aP) vaccines, incidence in the US and other countries that made this vaccine substitution, have seen incidence rates rise. Epidemiologic and experimental data suggest that a key limitation of aP vaccines is that they do not block asymptomatic carriage and spread. However, the existence of an asymptomatic carrier state for B. pertussis has never been proven, but this is because the question has never before been asked in an appropriately designed, longitudinal, cohort study, with systematic sample and symptoms collection over time. In a previous birth cohort study, the Southern Africa Mother Infant Pertussis Study, we collected ~20,000 nasopharyngeal (NP) swabs from 2000 Zambian mother/infant pairs, from birth through 14 weeks of age, with symptoms catalogued in parallel. Preliminary analysis of this set suggests that pertussis is common among the infants. Moreover, nearly all of the mothers of the infected infants were also infected with pertussis, though few showed any symptoms. This is presumptive evidence of asymptomatic carriage, but rests only on analysis of about 10% of the total sample library. We contend that full analysis of this sample library could provide insight into the epidemiology and transmission patterns of B. pertussis in ways never before possible. Data from this proposed analysis of the library can answer fundamental questions about asymptomatic carriage, its frequency, and concurrence within the mother/infant pair, and will also be invaluable for updating mathematical models of pertussis transmission, allowing us to answer, for the first time, what proportion of overall pertussis transmission occurs via asymptomatic chains?

项目摘要 百日咳由百日咳杆菌引起，是所有传染病中传染性最强的一种， 也是所有疫苗可预防的儿科疾病中控制最差的。自从改用无细胞的 百日咳（aP）疫苗，在美国和其他国家的发病率，使这种疫苗的替代，已经看到， 发病率上升。流行病学和实验数据表明，aP疫苗的一个关键限制是， 它们不能阻止无症状的携带和传播。然而，无症状携带者状态的存在 对于B。百日咳从来没有被证实过，但这是因为这个问题以前从来没有被问过。 适当设计的纵向队列研究，随着时间的推移进行系统的样本和症状收集。 在以前的出生队列研究，南部非洲母婴百日咳研究，我们收集了约20000 来自2000对赞比亚母亲/婴儿的鼻咽拭子（NP），从出生到14周龄， 症状分类并行。对这组病例的初步分析表明，百日咳在以下人群中很常见： 那些婴儿此外，几乎所有受感染婴儿的母亲也感染了百日咳， 很少有人出现任何症状。这是无症状携带的推定证据，但仅基于分析 约占总样本库的10%。我们认为，对这个样本库的全面分析可以提供 深入了解B的流行病学和传播模式。以前所未有的方式感染百日咳数据 从这个建议的分析库可以回答基本的问题，无症状携带，其 频率，和母亲/婴儿对内的并发，也将是非常宝贵的更新数学 百日咳传播的模型，让我们第一次回答， 传播是通过无症状的链条进行的？

项目成果

Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers.

• DOI: 10.7554/elife.65663
• 发表时间: 2021-06-07
• 期刊: eLife
• 影响因子: 7.7
• 作者: Gill CJ;Gunning CE;MacLeod WB;Mwananyanda L;Thea DM;Pieciak RC;Kwenda G;Mupila Z;Rohani P
• 通讯作者: Rohani P

Implementation and adherence of routine pertussis vaccination (DTP) in a low-resource urban birth cohort.

• DOI: 10.1136/bmjopen-2020-041198
• 发表时间: 2020-12-31
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Gunning CE;Mwananyanda L;MacLeod WB;Mwale M;Thea DM;Pieciak RC;Rohani P;Gill CJ
• 通讯作者: Gill CJ

Young Zambian infants with symptomatic RSV and pertussis infections are frequently prescribed inappropriate antibiotics: a retrospective analysis.

• DOI: 10.7717/peerj.15175
• 发表时间: 2023
• 期刊: PeerJ
• 影响因子: 2.7
• 作者: Gunning CE;Rohani P;Mwananyanda L;Kwenda G;Mupila Z;Gill CJ
• 通讯作者: Gill CJ