SAMIPS-NPC: Southern Africa Mother Infant Pertussis Study, Nasopharyngeal Carriage

SAMIPS-NPC：南部非洲母婴百日咳研究，鼻咽运输

• 批准号: 9761440
• 负责人: Christopher J GILL
• 金额: $ 72.55万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761440
• 关键词: Address; Advisory Committees; Affect; African; Age; Animals; Birth; Birth Intervals; Bordetella pertussis; Boston; Carrier State; Catalogs; Cells; Centers for Disease Control and Prevention (U.S.); Cessation of life; Childhood; Childhood Acute Lymphocytic Leukemia; Clinical; Cohort Studies; Collection; Communicable Diseases; Conjugate Vaccines; Country; Data; Diagnostic; Disease; Effectiveness; Enrollment; Epidemiology; Event; Evolution; Failure; Foundations; Frequencies; Funding; HIV; Haemophilus influenzae; Herd Immunity; Household; Human; Immunization; Immunology; Incidence; Incubated; Individual; Infant; Lead; Libraries; Life; Longitudinal Studies; Longitudinal cohort study; Mathematics; Measures; Modeling; Mothers; Neisseria meningitidis; Newborn Infant; Nuclear Pore Complex; Papio; Participant; Pattern; Pertussis; Pertussis Vaccine; Policies; Population; Postpartum Period; Prevalence; Public Health; Research; Research Personnel; Resources; Rest; Risk; Role; Sampling; Sampling Studies; Selection Bias; Southern Africa; Specific qualifier value; Streptococcus pneumoniae; Swab; Symptoms; Time; Update; Vaccinated; Vaccination; Vaccines; Zambia; base; cohort; design; experience; insight; mathematical model; neonatal infection; prevent; sample collection; theories; transmission process; uptake; vaccinology; willingness

Project Summary Whooping cough, caused by Bordetella pertussis, is one of the most contagious of all contagious diseases, and the least well controlled of all vaccine preventable pediatric diseases. Since switching to acellular pertussis (aP) vaccines, incidence in the US and other countries that made this vaccine substitution, have seen incidence rates rise. Epidemiologic and experimental data suggest that a key limitation of aP vaccines is that they do not block asymptomatic carriage and spread. However, the existence of an asymptomatic carrier state for B. pertussis has never been proven, but this is because the question has never before been asked in an appropriately designed, longitudinal, cohort study, with systematic sample and symptoms collection over time. In a previous birth cohort study, the Southern Africa Mother Infant Pertussis Study, we collected ~20,000 nasopharyngeal (NP) swabs from 2000 Zambian mother/infant pairs, from birth through 14 weeks of age, with symptoms catalogued in parallel. Preliminary analysis of this set suggests that pertussis is common among the infants. Moreover, nearly all of the mothers of the infected infants were also infected with pertussis, though few showed any symptoms. This is presumptive evidence of asymptomatic carriage, but rests only on analysis of about 10% of the total sample library. We contend that full analysis of this sample library could provide insight into the epidemiology and transmission patterns of B. pertussis in ways never before possible. Data from this proposed analysis of the library can answer fundamental questions about asymptomatic carriage, its frequency, and concurrence within the mother/infant pair, and will also be invaluable for updating mathematical models of pertussis transmission, allowing us to answer, for the first time, what proportion of overall pertussis transmission occurs via asymptomatic chains?

项目摘要 百日草引起的百日咳是所有感染性疾病中最具传染性的咳嗽， 以及所有可预防的小儿疾病的最不受欢迎的控制。自从切换到细胞 百日咳（AP）疫苗是美国和其他替代疫苗的国家的发病率 发病率上升。流行病学和实验数据表明，AP疫苗的关键局限性是 它们不会阻止无症状的载体和扩散。但是，存在无症状的载体状态 因为百日咳芽孢杆菌从未得到证明，但这是因为以前从未提问过这个问题 适当设计，纵向，队列研究，随着时间的推移，系统样本和症状收集。 在先前的出生队列研究中，南部非洲的母亲百日咳研究，我们收集了约20,000 2000年赞比亚母亲/婴儿对的鼻咽（NP）拭子从出生到14周龄， 并行分类症状。对此集的初步分析表明，百日咳很常见 婴儿。此外，几乎所有受感染婴儿的母亲也都感染了百日咳 很少有任何症状。这是无症状运输的推定证据，但仅取决于分析 约占样本库的10％。我们认为对该示例库的完整分析可以提供 以前所未有的方式了解百日咳的流行病学和传播模式。数据 通过对图书馆的拟议分析，可以回答有关无症状运输的基本问题 母亲/婴儿对中的频率和同意，对于更新数学而言也是无价的 百日咳传播的模型，使我们能够首次回答整体百老汇的比例 传播是通过无症状链发生的？

项目成果

Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers.

• DOI: 10.7554/elife.65663
• 发表时间: 2021-06-07
• 期刊: eLife
• 影响因子: 7.7
• 作者: Gill CJ;Gunning CE;MacLeod WB;Mwananyanda L;Thea DM;Pieciak RC;Kwenda G;Mupila Z;Rohani P
• 通讯作者: Rohani P

Asymptomatic Bordetella pertussis infections in young African infants and their mothers identified within a longitudinal cohort.

• DOI: 10.1101/2020.11.18.20231423
• 发表时间: 2020-11-19
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Gill, C J;Gunning, C E;Rohani, P
• 通讯作者: Rohani, P

Young Zambian infants with symptomatic RSV and pertussis infections are frequently prescribed inappropriate antibiotics: a retrospective analysis.

• DOI: 10.7717/peerj.15175
• 发表时间: 2023
• 期刊: PeerJ
• 影响因子: 2.7
• 作者: Gunning CE;Rohani P;Mwananyanda L;Kwenda G;Mupila Z;Gill CJ
• 通讯作者: Gill CJ

Implementation and adherence of routine pertussis vaccination (DTP) in a low-resource urban birth cohort.

• DOI: 10.1136/bmjopen-2020-041198
• 发表时间: 2020-12-31
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Gunning CE;Mwananyanda L;MacLeod WB;Mwale M;Thea DM;Pieciak RC;Rohani P;Gill CJ
• 通讯作者: Gill CJ