Ultrahigh-Field MRI of Hip Joint Diseases Leading to Early Osteoarthritis

项目摘要：这个K01奖项将为Casey P.Johnson博士提供培训和保护时间， 博士，开发一个独立的研究计划，以满足对新的成像解决方案的迫切需求 改善发育性髋关节疾病的临床管理，这些疾病是骨关节炎(OA)的先兆。 由于骨性关节炎没有治愈的方法，最终的治疗是全髋关节置换，因此诊断和治疗势在必行 在不可逆转的损伤发生之前及早进行髋关节病理检查，以防止长期残疾和进展为骨性关节炎。 然而，这些疾病的管理，包括(除其他外)莱格-卡尔维-珀斯病(LCPD) 以及髋臼撞击(FAI)，由于缺乏敏感和高空间分辨率的成像而受到阻碍 评估早期、潜在可治疗的骨和软骨损伤的工具。为了应对这一挑战，Dr。 约翰逊将开发和验证使用超高场(UHF)定量评估髋关节损伤的技术 (≥7特斯拉)磁共振成像，高空间分辨率成像的技术未来 肌肉骨骼(MSK)系统。约翰逊博士在开发高效、 定量和高分辨率核磁共振方法及其在血管和脑部疾病中的应用，使他 唯一有资格推进多因素MSK疾病的超高频磁共振成像。在K01奖的五年期间 在培训期间，约翰逊博士将发展他在MSK成像研究方面的专业知识，提升他的专业水平 技能，并在MSK和MRI研究领域建立支持网络。他将由和指导 与放射学、矫形外科、病理学、兽医和超高频核磁共振专家合作， 通过课程作业、研讨会、研讨会、科学会议和实践，接受有组织的培训 经历。约翰逊博士的研究将被植入明尼苏达大学研究中心 磁共振研究，世界知名的研究环境的开发和应用 超高频核磁共振技术。两个具体目标将在以下方面提供培训：(1)使用 小口径9.4T磁共振成像系统，具有组织学验证；以及(Ii)使用全身对患者进行临床成像 7T磁共振成像系统，经手术验证。Aim 1将在仔猪模型中进行开发和组织学验证 LCPD，定量评估早期缺血引起的股骨头骨髓，软骨， 还有骨头。这将解决儿童LCPD在股骨头粉碎化之前分期的需要。目标2将 在FAI患者中开发并在关节镜下验证定量评估软骨和 唇部受损。这将解决确定损害程度以确定修复候选对象的需要 关节镜手术。超高频磁共振成像的开发将重点放在使用Short和ρ的T2、T2*和T1 MRI映射 超短回波时间序列用于量化具有慢速(软骨和骨髓)和快速(骨骼)的组织 和唇部)衰减的MRI信号。这项研究将为约翰逊博士的进步提供坚实的基础 为改善患有髋关节和其他关节疾病的年轻患者的长期临床结果而进行的影像检查。

PROJECT SUMMARY: This K01 award will provide training and protected time for Dr. Casey P. Johnson, PhD, to develop an independent research program to address a critical need for new imaging solutions to improve the clinical management of developmental hip joint diseases that are precursors to osteoarthritis (OA). As there is no cure for OA and end treatment is total hip replacement, it is imperative to diagnose and treat early hip pathologies before irreversible damage occurs to prevent long-term disability and progression to OA. However, management of these diseases, which include (among others) Legg-Calve-Perthes disease (LCPD) and femoroacetabular impingement (FAI), is hindered by a lack of sensitive and high-spatial-resolution imaging tools to evaluate early, potentially treatable, bone and cartilage damage. To address this challenge, Dr. Johnson will develop and validate techniques to quantitatively assess hip damage using ultrahigh-field (UHF) (≥7 Tesla) magnetic resonance imaging (MRI), the technological future for high-spatial-resolution imaging of the musculoskeletal (MSK) system. Dr. Johnson has a strong background in the development of efficient, quantitative, and high-resolution MRI methods and their application to vascular and brain diseases, making him uniquely qualified to advance UHF MRI of multifactorial MSK diseases. During the K01 award’s five-year training period, Dr. Johnson will develop his expertise in MSK imaging research, enhance his professional skills, and establish a network of support within the MSK and MRI research fields. He will be mentored by and collaborate with experts in radiology, orthopaedic surgery, pathology, veterinary medicine, and UHF MRI and receive structured training through coursework, seminars, workshops, scientific conferences, and hands-on experiences. Dr. Johnson’s research will be embedded within the University of Minnesota’s Center for Magnetic Resonance Research, a world-renowned research environment for the development and application of UHF MRI technology. Two specific aims will provide training in: (i) preclinical imaging of specimens using a small-bore 9.4T MRI system with histological validation; and (ii) clinical imaging of patients using a whole-body 7T MRI system with surgical validation. Aim 1 will develop and histologically validate, in a piglet model of LCPD, techniques to quantitatively assess early ischemia-induced changes to femoral head marrow, cartilage, and bone. This will address a need to stage LCPD in children prior to femoral head fragmentation. Aim 2 will develop and arthroscopically validate, in patients with FAI, techniques to quantitatively assess cartilage and labral damage. This will address a need to determine the extent of damage to identify candidates for reparative arthroscopic surgery. UHF MRI development will focus on T2, T2*, and T1ρ mapping using both short and ultrashort echo-time sequences to quantify tissues with both slowly- (cartilage and marrow) and rapidly- (bone and labrum) decaying MRI signals. This research will provide Dr. Johnson with a strong foundation to advance imaging to improve long-term clinical outcomes for young patients with hip and other joint diseases.