University of Pennsylvania+ PLUS Clinical Center (PENN+PLUS CC)

宾夕法尼亚大学 PLUS 临床中心 (PENN PLUS CC)

• 批准号: 9761519
• 负责人: Diane K. Newman
• 金额: $ 56.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-25 至 2020-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761519
• 关键词: Address; Affect; Age; Area; Attitude; Behavior; Behavioral; Bioinformatics; Bladder; Clinical; Clinical Data; Clinical Trials; Cohort Studies; Collaborations; Comorbidity; Data; Databases; Development; Diet Modification; Distress; Elderly; Electronic Health Record; Epidemiology; Evaluation; Female; Female Adolescents; Goals; Habits; Health; Health Care Costs; Health Services Research; Incidence; Individual; Interstitial Cystitis; Intervention; Lead; Life; Liquid substance; Longevity; Longitudinal Studies; Low Prevalence; Medicine; Meta-Analysis; Methodology; Modeling; Multicenter Trials; Observational Study; Overactive Bladder; Pattern; Pennsylvania; Perception; Phase; Population; Population Study; Predictive Factor; Prevalence; Prevention; Prevention Research; Preventive Intervention; Publishing; Qualitative Research; Quality of life; Randomized Controlled Trials; Recurrence; Reporting; Research; Research Methodology; Risk; Risk Factors; Site; Surveys; Symptoms; Team Nursing; Testing; Training; Universities; Urinary Incontinence; Urinary tract infection; Urination; Urology; Woman; age group; base; bladder pain; cost; design; effective intervention; epidemiology study; experience; help-seeking behavior; improved; instrument; lifetime risk; lower urinary tract symptoms; member; middle age; modifiable risk; older women; prevent; protective factors; public health relevance; racial and ethnic; reproductive; response; symptom management; systematic review; young adult; young woman

 DESCRIPTION (provided by applicant): Lower urinary tract symptoms are prevalent, distressing, and costly for women across the life span. They are characterized by storage, voiding, and postmicturition symptoms, and associated with urinary tract infections, overactive bladder, and bladder pain syndrome. The occurrence of lower urinary tract symptoms implies an "abnormal" or unhealthy bladder. Promotion of bladder health through treatment of modifiable risk factors and improving bladder habits may decrease the incidence of these symptoms over a woman's lifetime. Our long-term goal is to develop effective interventions to reduce the lifetime risk of lower urinary tract symptoms and urinary tract infections in women across four life-stage groups: adolescent girls (pre-reproductive years); young adult (reproductive years), midlife (post- reproductive years) and older women (65 years and older). We plan to: 1) examine the utility of an adaption of the Symptom Management Model to identify risk and protective factors that predict bladder health in the four life-stages; 2) examine the shared and unique impact of risk and protective factors on lower urinary tract symptoms and urinary tract infection in women in each of the four age groups; and 3) design and conduct qualitative and cohort studies and clinical trials in collaboration with PLUS Research Consortium members that are focused on identifying and reducing risk factors related to bladder health in women. Specifically, we will conduct an evidence synthesis on the risk and protective factors and preventive interventions for lower urinary tract symptoms; use qualitative methodology to describe adolescent girls and women's bladder health experiences and their symptom management strategies; develop an instrument to be used in longitudinal studies in consortium sites based on our qualitative research results; and use epidemiological and electronic health record databases (including clinical data and claims data) to determine risk factors for urinary tract infections in women. In addition, we will design and conduct multisite observational studies and randomized controlled trials in collaboration with PLUS Research Consortium to identify and reduce risk factors associated with bladder health in selected female populations.

 描述（由申请人提供）：下尿路症状是普遍的，痛苦的，和昂贵的妇女在整个生命周期。其特征是储尿、排尿和排尿后症状，并与尿路感染、膀胱过度活动症和膀胱疼痛综合征有关。下尿路症状的发生意味着“异常”或不健康的膀胱。通过治疗可改变的风险因素和改善膀胱习惯来促进膀胱健康，可能会降低女性一生中这些症状的发生率。我们的长期目标是制定有效的干预措施，以降低四个生命阶段组女性下尿路症状和尿路感染的终生风险：青春期女孩（生育前年龄）;年轻成年人（生育年龄），中年（生育后年龄）和老年妇女（65岁及以上）。我们计划：1）检查适应症状管理模型的效用，以识别预测四个生命阶段中膀胱健康的风险和保护因素; 2）检查风险和保护因素对四个年龄组中每个年龄组的女性下尿路症状和尿路感染的共同和独特影响;和3）与PLUS研究联盟成员合作设计和进行定性和队列研究以及临床试验，重点是识别和减少与女性膀胱健康相关的风险因素。具体来说，我们将进行证据合成的风险和保护因素和预防性干预措施下尿路症状;使用定性方法来描述青春期女孩和妇女的膀胱健康的经验和他们的症状管理策略;开发一个工具，用于纵向研究在财团网站的基础上，我们的定性研究结果;使用流行病学和电子健康记录数据库（包括临床数据和索赔数据）来确定妇女尿路感染的风险因素。此外，我们将与PLUS研究联盟合作设计和开展多中心观察性研究和随机对照试验，以确定和减少选定女性人群中与膀胱健康相关的风险因素。