African Caribbean Cancer Consortium Scientific and Training Conference

项目总结/摘要 非洲-加勒比癌症联盟（AC 3）是一个指定的NCI-Epidemiology and Genomics Research （EGRP）Consortium. AC 3通过照顾非洲裔美国人以及加勒比和非洲裔美国人发挥着独特的作用。 美国移民（U.S.）和他们的祖国。我们的联盟成员是跨- 学科（基础和人口科学研究人员，临床医生和癌症倡导者），由三个 互联网络（美国，加勒比和非洲），涉及40多个机构。我们的2019会议 主题为“细胞对社会的方法，以减少癌症风险和改善非洲人口的结果”。 “跨学科”与我们成员的跨学科构成有关。大规模比较翻译 癌症研究，包括分子到人口为基础的研究是至关重要的，以加快我们的 努力理解和解决癌症差异。考虑到美国黑人人口的多样性， 加勒比和非洲的癌症研究也是解决癌症差异的重要组成部分， 美国国家卫生研究院的会议支持提供了培训和网络机会， AC 3在审查和解决涉及多层次因素的差异方面的作用和责任日益增加 影响非洲血统人群的癌症风险、流行病学和结果。的初步结果 我们的2018年需求评估显示，为了维持 美国--加勒比-非洲合作。这些差距包括资助精神、参与和管理的准备程度 协作申请补助金，参与者招募期间和国内收集数据的有效方法 加勒比和非洲研究人员的分子病理学技能。2019年会议将重点关注a） B）为特定的大规模比较翻译制定AC 3行动计划， 涉及非裔美国人、移民和非洲及加勒比地区土著人口的癌症研究， 利用我们已经建立的资源。这种方法在美国最有利，因为 比较研究对于告知和改善癌症的干预、治疗和预防至关重要， 美国黑人具体目标如下：1）促进与癌症风险相关的知识转移， 在非洲裔人口中取得的成果，并促进研究的发展和协调 涉及非洲裔美国人、非洲加勒比人和非洲人。2)促进健康管道的多样性 为代表性不足的少数群体提供培训和职业发展论坛， 调查员和学生。3)通过提供科学严谨、临床和文化上的 知情的研究和教育，为更大的公共利益，以提高知识，癌症的风险， 减少和预防癌症风险的战略，并产生符合文化特点的社区反应 研究招募服务不足/研究不足的人口。

PROJECT SUMMARY/ABSTRACT The African-Caribbean Cancer Consortium (AC3) is a designated NCI-Epidemiology and Genomics Research (EGRP) Consortium. AC3 plays a unique role by attending to African American as well as Caribbean and African immigrants in the United States (U.S.) and their native countries. Our consortium membership is trans- disciplinary (basic and population science researchers, clinicians, and cancer advocates) and consists of three interconnected networks (U.S., Caribbean and Africa) involving more than 40 institutions. Our 2019 conference theme “Cell to Society Approaches to Reduce Cancer Risk and Improve Outcomes among Populations of African Ancestry” is relevant to the transdisciplinary makeup of our membership. Large-scale comparative translational cancer research studies that encompass molecular to population-based research are critical to accelerating our efforts in understanding and addressing cancer disparities. Considering the diversity of the U.S Black population, cancer research in the Caribbean and Africa is also an essential component for addressing cancer disparities in the U.S. Prior NIH conference support has provided training and networking opportunities that have facilitated AC3’s growing role and responsibility in examining and addressing disparities involving multi-level factors affecting cancer risk, epidemiology and outcomes of populations of African ancestry. Preliminary results from our 2018 needs assessment reveal that there are still remaining gaps that must be addressed in order to sustain U.S.-Caribbean-Africa collaborations. These gaps include grantsmanship, readiness to participate and manage collaborative grant applications, efficient methods for data capture during participant recruitment and in-country molecular pathology skills for Caribbean and African investigators. The 2019 conference will focus on a) addressing these gaps and b) developing an AC3 action plan for specific large-scale comparative translational cancer research studies involving African Americans, immigrant and native African and Caribbean populations, leveraging on the resources that we have already built. This approach would be most beneficial in the U.S. as comparative studies are critical to inform and improve interventions, treatment and prevention of cancers among U.S. Blacks. The following are the Specific Aims: 1) To facilitate knowledge transfer related to cancer risk and outcomes in African-descent populations, and promote the development and coordination of research studies involving African-American, African-Caribbean and African populations. 2) Promote diversity pipeline for health disparities research by providing a forum for training and career development for under-represented minority investigators and students. 3) To promote health equity by providing scientifically rigorous, clinically and culturally informed research and education for greater public benefit in order to improve knowledge, of cancer risk, strategies for cancer risk reduction and prevention, and generate culturally tailored community responsive research recruitment of underserved/understudied populations.